Modulation of the Intracortical LFP during Action Execution and Observation
Modulation of the Intracortical LFP during Action Execution and Observation
The activity of mirror neurons in macaque ventral premotor cortex (PMv) and primary motor cortex (M1) is modulated by the observation of another's movements. This modulation could underpin well documented changes in EEG/MEG activity indicating the existence of a mirror neuron system in humans. Because the local field potential (LFP) represents an important link between macaque single neuron and human noninvasive studies, we focused on mirror properties of intracortical LFPs recorded in the PMv and M1 hand regions in two macaques while they reached, grasped and held different objects, or observed the same actions performed by an experimenter. Upper limb EMGs were recorded to control for covert muscle activity during observation.The movement-related potential (MRP), investigated as intracortical low-frequency LFP activity (<9 Hz), was modulated in both M1 and PMv, not only during action execution but also during action observation. Moreover, the temporal LFP modulations during execution and observation were highly correlated in both cortical areas. Beta power in both PMv and M1 was clearly modulated in both conditions. Although the MRP was detected only during dynamic periods of the task (reach/grasp/release), beta decreased during dynamic and increased during static periods (hold).Comparison of LFPs for different grasps provided evidence for partially nonoverlapping networks being active during execution and observation, which might be related to different inputs to motor areas during these conditions. We found substantial information about grasp in the MRP corroborating its suitability for brain-machine interfaces, although information about grasp was generally low during action observation.
Action Potentials/physiology, Animals, Electroencephalography, Electromyography, Evoked Potentials, Motor/physiology, Hand Strength, Macaca mulatta, Male, Mirror Neurons/physiology, Motor Cortex/cytology, Movement/physiology, Observation, Psychomotor Performance, Reaction Time/physiology
8451-8461
Waldert, Stephan
966d8435-d9d8-42c5-be20-4951026ee210
Vigneswaran, Ganesh
4e3865ad-1a15-4a27-b810-55348e7baceb
Philipp, Roland
56a4fa3b-d302-4cb8-8e74-ef98ea64a52f
Lemon, Roger N
b1bff74a-af36-4b2c-aa68-a9737793d5f2
Kraskov, Alexander
10cac203-e863-445f-a201-11bd2e62274a
3 June 2015
Waldert, Stephan
966d8435-d9d8-42c5-be20-4951026ee210
Vigneswaran, Ganesh
4e3865ad-1a15-4a27-b810-55348e7baceb
Philipp, Roland
56a4fa3b-d302-4cb8-8e74-ef98ea64a52f
Lemon, Roger N
b1bff74a-af36-4b2c-aa68-a9737793d5f2
Kraskov, Alexander
10cac203-e863-445f-a201-11bd2e62274a
Waldert, Stephan, Vigneswaran, Ganesh, Philipp, Roland, Lemon, Roger N and Kraskov, Alexander
(2015)
Modulation of the Intracortical LFP during Action Execution and Observation.
Journal of Neuroscience, 35 (22), .
(doi:10.1523/JNEUROSCI.5137-14.2015).
Abstract
The activity of mirror neurons in macaque ventral premotor cortex (PMv) and primary motor cortex (M1) is modulated by the observation of another's movements. This modulation could underpin well documented changes in EEG/MEG activity indicating the existence of a mirror neuron system in humans. Because the local field potential (LFP) represents an important link between macaque single neuron and human noninvasive studies, we focused on mirror properties of intracortical LFPs recorded in the PMv and M1 hand regions in two macaques while they reached, grasped and held different objects, or observed the same actions performed by an experimenter. Upper limb EMGs were recorded to control for covert muscle activity during observation.The movement-related potential (MRP), investigated as intracortical low-frequency LFP activity (<9 Hz), was modulated in both M1 and PMv, not only during action execution but also during action observation. Moreover, the temporal LFP modulations during execution and observation were highly correlated in both cortical areas. Beta power in both PMv and M1 was clearly modulated in both conditions. Although the MRP was detected only during dynamic periods of the task (reach/grasp/release), beta decreased during dynamic and increased during static periods (hold).Comparison of LFPs for different grasps provided evidence for partially nonoverlapping networks being active during execution and observation, which might be related to different inputs to motor areas during these conditions. We found substantial information about grasp in the MRP corroborating its suitability for brain-machine interfaces, although information about grasp was generally low during action observation.
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Published date: 3 June 2015
Keywords:
Action Potentials/physiology, Animals, Electroencephalography, Electromyography, Evoked Potentials, Motor/physiology, Hand Strength, Macaca mulatta, Male, Mirror Neurons/physiology, Motor Cortex/cytology, Movement/physiology, Observation, Psychomotor Performance, Reaction Time/physiology
Identifiers
Local EPrints ID: 448614
URI: http://eprints.soton.ac.uk/id/eprint/448614
ISSN: 0270-6474
PURE UUID: 5c1b51eb-28eb-45fd-b864-bfd7202c8e05
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Date deposited: 28 Apr 2021 16:32
Last modified: 17 Mar 2024 04:06
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Author:
Stephan Waldert
Author:
Roland Philipp
Author:
Roger N Lemon
Author:
Alexander Kraskov
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