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Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance

Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance
Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance
It is challenging to investigate fast supramolecular processes due to the lack of appropriate characterization methods with high structural resolution. In this
study, microfluidic nuclear magnetic resonance (μFNMR) spectroscopy was employed to monitor the kinetics of threading and dethreading of a pseudo
[6]rotaxane system. By employing high time resolution μF-NMR, 1
H and two-dimensional (2D) rotating frame nuclear Overhauser effect spectroscopy (ROESY) NMR spectra were recorded at any time
point within 1.5 s after the onset of the process. This technique enabled the successful identification of kinetic intermediates and rate-determining steps,
usually impossible to determine by other spectroscopic techniques. Thus, our study demonstrates the capability of μF-NMR in investigating the mechanism
of complex supramolecular systems.
cucurbit[7]uril, β-Cyclodextrin, host-guest chemistry, kinetics, microfluidics NMR
2192-6549
948–956
Sun, Yibin
e771c98f-f275-45be-bd04-eb48bc3db2ba
Fang, Hongxun
a85933d0-7747-4b6b-aca5-e545e41f5d56
Lin, Xujing
88d0fa2e-bb69-4234-9528-87d0fbd8ee81
Wang, Xiuxiu
ef12857d-2a9c-45a3-9bdc-d90370b18f23
Chen, Ganyu
b721a924-4b77-463d-bc2a-64b7adbbf17d
Wang, Xinchang
d68c3b67-d334-485f-9d7f-fd768a11442d
Tian, Zhongqun
1d4df9bf-8b6a-4191-bc3a-91bc107ed580
Yang, Liulin
a4105373-ef07-4b51-9a56-b59f9fd78089
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Cao, Xiaoyu
7835d358-56da-482e-b061-c76c847a1525
Sun, Yibin
e771c98f-f275-45be-bd04-eb48bc3db2ba
Fang, Hongxun
a85933d0-7747-4b6b-aca5-e545e41f5d56
Lin, Xujing
88d0fa2e-bb69-4234-9528-87d0fbd8ee81
Wang, Xiuxiu
ef12857d-2a9c-45a3-9bdc-d90370b18f23
Chen, Ganyu
b721a924-4b77-463d-bc2a-64b7adbbf17d
Wang, Xinchang
d68c3b67-d334-485f-9d7f-fd768a11442d
Tian, Zhongqun
1d4df9bf-8b6a-4191-bc3a-91bc107ed580
Yang, Liulin
a4105373-ef07-4b51-9a56-b59f9fd78089
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Cao, Xiaoyu
7835d358-56da-482e-b061-c76c847a1525

Sun, Yibin, Fang, Hongxun, Lin, Xujing, Wang, Xiuxiu, Chen, Ganyu, Wang, Xinchang, Tian, Zhongqun, Yang, Liulin, Utz, Marcel and Cao, Xiaoyu (2021) Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance. Chemistry, 2021 (3), 948–956. (doi:10.31635/ccschem.021.202100773).

Record type: Article

Abstract

It is challenging to investigate fast supramolecular processes due to the lack of appropriate characterization methods with high structural resolution. In this
study, microfluidic nuclear magnetic resonance (μFNMR) spectroscopy was employed to monitor the kinetics of threading and dethreading of a pseudo
[6]rotaxane system. By employing high time resolution μF-NMR, 1
H and two-dimensional (2D) rotating frame nuclear Overhauser effect spectroscopy (ROESY) NMR spectra were recorded at any time
point within 1.5 s after the onset of the process. This technique enabled the successful identification of kinetic intermediates and rate-determining steps,
usually impossible to determine by other spectroscopic techniques. Thus, our study demonstrates the capability of μF-NMR in investigating the mechanism
of complex supramolecular systems.

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ccschem.021.202100773 - Version of Record
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More information

Accepted/In Press date: 24 February 2021
e-pub ahead of print date: 12 April 2021
Keywords: cucurbit[7]uril, β-Cyclodextrin, host-guest chemistry, kinetics, microfluidics NMR

Identifiers

Local EPrints ID: 448727
URI: http://eprints.soton.ac.uk/id/eprint/448727
ISSN: 2192-6549
PURE UUID: b5dbbe98-b6c7-4c02-9099-7a3f8c74d0b1
ORCID for Marcel Utz: ORCID iD orcid.org/0000-0003-2274-9672

Catalogue record

Date deposited: 04 May 2021 16:37
Last modified: 05 May 2021 01:45

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Contributors

Author: Yibin Sun
Author: Hongxun Fang
Author: Xujing Lin
Author: Xiuxiu Wang
Author: Ganyu Chen
Author: Xinchang Wang
Author: Zhongqun Tian
Author: Liulin Yang
Author: Marcel Utz ORCID iD
Author: Xiaoyu Cao

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