Prostatic Artery Embolization (PAE) and Transurethral Resection of the Prostate (TURP) have a differential impact on Lower Urinary Tract Symptoms (LUTS): Retrospective Analysis of the Multicentre UK-ROPE (UK Register of Prostate Embolization) Study
Prostatic Artery Embolization (PAE) and Transurethral Resection of the Prostate (TURP) have a differential impact on Lower Urinary Tract Symptoms (LUTS): Retrospective Analysis of the Multicentre UK-ROPE (UK Register of Prostate Embolization) Study
PURPOSE: To compare the relative IPSS (International Prostate Symptom Score) improvement in storage and voiding symptoms between prostatic artery embolization (PAE) and transurethral resection of the prostate (TURP).
METHOD: Retrospective analysis of the UK-ROPE (UK Register of Prostate Embolization) multicentre database was conducted with inclusion of all patients with full IPSS questionnaire score data. The voiding and storage subscore improvement was compared between interventions. Student's t-test (paired and unpaired) and ANOVA (Analysis of variance) were used to identify significant differences between the groups.
RESULTS: 146 patients (121 PAE, 25 TURP) were included in the analysis. Storage symptoms were more frequently the most severe symptom ('storage' in 75 patients vs 'voiding' in 17 patients). Between groups, no significant difference was seen in raw storage subscore improvement (TURP 4.9 vs PAE 4.2; p = 0.34) or voiding subscore improvement (TURP 8.4 vs PAE 6.7; p = 0.1). ANOVA demonstrated a greater proportionate reduction (relative to total IPSS) towards voiding symptoms in the TURP group (27.3% TURP vs 9.9% PAE, p = 0.001).
CONCLUSION: Although both TURP and PAE improve voiding symptoms more than storage, a significantly larger proportion of total symptom reduction is due to voiding in the TURP cohort, with PAE providing a more balanced improvement between voiding and storage.
1095-1102
Vigneswaran, Ganesh
4e3865ad-1a15-4a27-b810-55348e7baceb
Maclean, Drew
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Hadi, Mohammed
098f3cf9-e312-4e54-bf7f-797c6cbea7a6
Maher, Benjamin
7fd9ad94-486a-412f-a88e-5db922b49617
Modi, Sachin
caef086a-dda5-418a-ada8-fc042e6e0b18
Bryant, Timothy
05bd12ef-e864-450e-96f5-addcc60c173d
Harris, Mark
065415f3-96a7-443c-91b4-f75a5945f82b
Hacking, Nigel
fdc70f9c-e9d6-485c-a53d-e6988fa75cb0
July 2021
Vigneswaran, Ganesh
4e3865ad-1a15-4a27-b810-55348e7baceb
Maclean, Drew
bf15fb9d-aa6d-4d13-8cae-ede6a3329779
Hadi, Mohammed
098f3cf9-e312-4e54-bf7f-797c6cbea7a6
Maher, Benjamin
7fd9ad94-486a-412f-a88e-5db922b49617
Modi, Sachin
caef086a-dda5-418a-ada8-fc042e6e0b18
Bryant, Timothy
05bd12ef-e864-450e-96f5-addcc60c173d
Harris, Mark
065415f3-96a7-443c-91b4-f75a5945f82b
Hacking, Nigel
fdc70f9c-e9d6-485c-a53d-e6988fa75cb0
Vigneswaran, Ganesh, Maclean, Drew, Hadi, Mohammed, Maher, Benjamin, Modi, Sachin, Bryant, Timothy, Harris, Mark and Hacking, Nigel
(2021)
Prostatic Artery Embolization (PAE) and Transurethral Resection of the Prostate (TURP) have a differential impact on Lower Urinary Tract Symptoms (LUTS): Retrospective Analysis of the Multicentre UK-ROPE (UK Register of Prostate Embolization) Study.
Cardiovascular and Interventional Radiology, 44 (7), .
(doi:10.1007/s00270-021-02821-5).
Abstract
PURPOSE: To compare the relative IPSS (International Prostate Symptom Score) improvement in storage and voiding symptoms between prostatic artery embolization (PAE) and transurethral resection of the prostate (TURP).
METHOD: Retrospective analysis of the UK-ROPE (UK Register of Prostate Embolization) multicentre database was conducted with inclusion of all patients with full IPSS questionnaire score data. The voiding and storage subscore improvement was compared between interventions. Student's t-test (paired and unpaired) and ANOVA (Analysis of variance) were used to identify significant differences between the groups.
RESULTS: 146 patients (121 PAE, 25 TURP) were included in the analysis. Storage symptoms were more frequently the most severe symptom ('storage' in 75 patients vs 'voiding' in 17 patients). Between groups, no significant difference was seen in raw storage subscore improvement (TURP 4.9 vs PAE 4.2; p = 0.34) or voiding subscore improvement (TURP 8.4 vs PAE 6.7; p = 0.1). ANOVA demonstrated a greater proportionate reduction (relative to total IPSS) towards voiding symptoms in the TURP group (27.3% TURP vs 9.9% PAE, p = 0.001).
CONCLUSION: Although both TURP and PAE improve voiding symptoms more than storage, a significantly larger proportion of total symptom reduction is due to voiding in the TURP cohort, with PAE providing a more balanced improvement between voiding and storage.
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Vigneswaran2021_Article_ProstaticArteryEmbolizationPAE
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Accepted/In Press date: 3 March 2021
e-pub ahead of print date: 6 April 2021
Published date: July 2021
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Local EPrints ID: 448755
URI: http://eprints.soton.ac.uk/id/eprint/448755
ISSN: 0174-1551
PURE UUID: da68c64e-96e5-4bb2-8f28-db55cbbd3267
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Date deposited: 05 May 2021 16:30
Last modified: 17 Mar 2024 04:06
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Author:
Drew Maclean
Author:
Mohammed Hadi
Author:
Benjamin Maher
Author:
Sachin Modi
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Timothy Bryant
Author:
Mark Harris
Author:
Nigel Hacking
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