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Hyperbaric oxygen ameliorates bleomycin-induced pulmonary fibrosis in mice

Hyperbaric oxygen ameliorates bleomycin-induced pulmonary fibrosis in mice
Hyperbaric oxygen ameliorates bleomycin-induced pulmonary fibrosis in mice
The prevalence of pulmonary fibrosis is increasing with an ageing population and its burden is likely 24 to increase following COVID-19, with large financial and medical implications. As approved therapies 25 in pulmonary fibrosis only slow disease progression there is a significant unmet medical need. 26 Hyperbaric oxygen (HBO) is the inhaling of pure oxygen, under the pressure of greater than one 27 atmosphere absolute and it has been reported to improve pulmonary function in patients with 28 pulmonary fibrosis. Our recent study suggested that repetitive HBO exposure may affect biological 29 processes in mice lungs such as response to wounding and extracellular matrix. To extend these 30 findings, a bleomycin-induced pulmonary fibrosis mouse model was used to evaluate the effect of 31 repetitive HBO exposure on pulmonary fibrosis. Building on our previous findings, we provide 32 evidence that HBO exposure attenuates bleomycin-induced pulmonary fibrosis in mice. In vitro, HBO 33 exposure could reverse, at least partially, transforming growth factor (TGF)-β-induced fibroblast 34 activation, and this effect may be mediated by down-regulating TGF-β-induced expression of hypoxia 35 inducible factor (HIF)-1α. These findings support HBO as a potentially life-changing therapy for 36 patients with pulmonary fibrosis, although further research is needed to fully evaluate this.
2296-889X
Yuan, Yuan
5d12e7ff-eadb-4999-a4cc-3b81ff46389e
Li, Yali
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Qiao, Guoqiang
c54394da-1da7-4fa5-9370-edc3d0ac3f5e
Zhou, Yilu
1878565d-39e6-467d-a027-7320bf4cdaf2
Xu, Zijian
052c41eb-6256-4ed8-94a4-ab0dfe0f87b1
Hill, Charlotte
6d1cfed3-11b1-48af-b171-b8726ab673eb
Jiang, Zhenglin
20983915-4af3-45ce-addd-976d9607bfed
Wang, Yihua
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Yuan, Yuan
5d12e7ff-eadb-4999-a4cc-3b81ff46389e
Li, Yali
d59073f9-d0cb-48cc-aca5-3b3e1d122e26
Qiao, Guoqiang
c54394da-1da7-4fa5-9370-edc3d0ac3f5e
Zhou, Yilu
1878565d-39e6-467d-a027-7320bf4cdaf2
Xu, Zijian
052c41eb-6256-4ed8-94a4-ab0dfe0f87b1
Hill, Charlotte
6d1cfed3-11b1-48af-b171-b8726ab673eb
Jiang, Zhenglin
20983915-4af3-45ce-addd-976d9607bfed
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e

Yuan, Yuan, Li, Yali, Qiao, Guoqiang, Zhou, Yilu, Xu, Zijian, Hill, Charlotte, Jiang, Zhenglin and Wang, Yihua (2021) Hyperbaric oxygen ameliorates bleomycin-induced pulmonary fibrosis in mice. Frontiers in Molecular Biosciences. (In Press)

Record type: Article

Abstract

The prevalence of pulmonary fibrosis is increasing with an ageing population and its burden is likely 24 to increase following COVID-19, with large financial and medical implications. As approved therapies 25 in pulmonary fibrosis only slow disease progression there is a significant unmet medical need. 26 Hyperbaric oxygen (HBO) is the inhaling of pure oxygen, under the pressure of greater than one 27 atmosphere absolute and it has been reported to improve pulmonary function in patients with 28 pulmonary fibrosis. Our recent study suggested that repetitive HBO exposure may affect biological 29 processes in mice lungs such as response to wounding and extracellular matrix. To extend these 30 findings, a bleomycin-induced pulmonary fibrosis mouse model was used to evaluate the effect of 31 repetitive HBO exposure on pulmonary fibrosis. Building on our previous findings, we provide 32 evidence that HBO exposure attenuates bleomycin-induced pulmonary fibrosis in mice. In vitro, HBO 33 exposure could reverse, at least partially, transforming growth factor (TGF)-β-induced fibroblast 34 activation, and this effect may be mediated by down-regulating TGF-β-induced expression of hypoxia 35 inducible factor (HIF)-1α. These findings support HBO as a potentially life-changing therapy for 36 patients with pulmonary fibrosis, although further research is needed to fully evaluate this.

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Accepted/In Press date: 30 April 2021

Identifiers

Local EPrints ID: 448811
URI: http://eprints.soton.ac.uk/id/eprint/448811
ISSN: 2296-889X
PURE UUID: 0d96bff1-5b97-4a0a-9569-a7c303c6b722
ORCID for Yihua Wang: ORCID iD orcid.org/0000-0001-5561-0648

Catalogue record

Date deposited: 06 May 2021 16:31
Last modified: 07 May 2021 01:48

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Contributors

Author: Yuan Yuan
Author: Yali Li
Author: Guoqiang Qiao
Author: Yilu Zhou
Author: Zijian Xu
Author: Charlotte Hill
Author: Zhenglin Jiang
Author: Yihua Wang ORCID iD

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