A more defective substrate leads to a less defective passive layer: enhancing the mechanical strength, corrosion resistance and antiinflammatory response of the low-modulus Ti-45Nb alloy by grain refinement
A more defective substrate leads to a less defective passive layer: enhancing the mechanical strength, corrosion resistance and antiinflammatory response of the low-modulus Ti-45Nb alloy by grain refinement
Orthopedic and dental implants made of β-type Ti alloys have low elastic modulus which can better relieve the stress shielding effects after surgical implantation. Nevertheless, clinical application of β-type Ti alloys is hampered by the insufficient mechanical strength and gradual release of pro-inflammatory metallic ions under physiological conditions. In this study, the β-type Ti-45Nb alloy is subjected to highpressure torsion (HPT) processing to refine the grain size. After HPT processing, the tensile strength increases from 370 MPa to 658 MPa due to grain boundary strengthening and at the same time, the favorable elastic modulus is maintained at a low level of 61-72 GPa because the single β-phase is preserved during grain refinement. More grain boundaries decrease the work function and facilitate the formation of thicker and less defective passive films leading to better corrosion resistance. In addition, more rapid repair of the passive layer mitigates release of metallic ions from the alloy and consequently, the inflammatory response is suppressed. The results reveal a strategy to simultaneously improve the mechanical and biological properties of metallic implant materials for orthopedics and dentistry.
Corrosion resistance, Grain-refinement, Inflammatory responses, Ion release, Orthopedic/dental implants, Ti-45Nb alloy
524-536
Hu, Nan
a6f039f8-6255-4eec-a4af-0650f6d61df8
Xie, Lingxia
6fc9141c-42d5-41dd-962b-a95700d75f9f
Gao, Nong
9c1370f7-f4a9-4109-8a3a-4089b3baec21
Starink, Marco
fe61a323-4e0c-49c7-91f0-4450e1ec1e51
Wang, Huaiyu
1e86fd87-7d0e-4e3c-8eb2-4af3d73c4fa6
May 2021
Hu, Nan
a6f039f8-6255-4eec-a4af-0650f6d61df8
Xie, Lingxia
6fc9141c-42d5-41dd-962b-a95700d75f9f
Gao, Nong
9c1370f7-f4a9-4109-8a3a-4089b3baec21
Starink, Marco
fe61a323-4e0c-49c7-91f0-4450e1ec1e51
Wang, Huaiyu
1e86fd87-7d0e-4e3c-8eb2-4af3d73c4fa6
Hu, Nan, Xie, Lingxia, Gao, Nong, Starink, Marco and Wang, Huaiyu
(2021)
A more defective substrate leads to a less defective passive layer: enhancing the mechanical strength, corrosion resistance and antiinflammatory response of the low-modulus Ti-45Nb alloy by grain refinement.
Acta Biomaterialia, 126, .
(doi:10.1016/j.actbio.2021.02.045).
Abstract
Orthopedic and dental implants made of β-type Ti alloys have low elastic modulus which can better relieve the stress shielding effects after surgical implantation. Nevertheless, clinical application of β-type Ti alloys is hampered by the insufficient mechanical strength and gradual release of pro-inflammatory metallic ions under physiological conditions. In this study, the β-type Ti-45Nb alloy is subjected to highpressure torsion (HPT) processing to refine the grain size. After HPT processing, the tensile strength increases from 370 MPa to 658 MPa due to grain boundary strengthening and at the same time, the favorable elastic modulus is maintained at a low level of 61-72 GPa because the single β-phase is preserved during grain refinement. More grain boundaries decrease the work function and facilitate the formation of thicker and less defective passive films leading to better corrosion resistance. In addition, more rapid repair of the passive layer mitigates release of metallic ions from the alloy and consequently, the inflammatory response is suppressed. The results reveal a strategy to simultaneously improve the mechanical and biological properties of metallic implant materials for orthopedics and dentistry.
Text
Manuscript_AB_20_2971R1
- Accepted Manuscript
More information
Accepted/In Press date: 28 February 2021
e-pub ahead of print date: 5 March 2021
Published date: May 2021
Additional Information:
Funding Information:
The authors acknowledge financial support from the National Natural Science Foundation of China (no. 31922040), Shenzhen Science and Technology Research Funding (nos. SGLH20180625144002074 and JCYJ20180507182637685), Youth Innovation Promotion Association of Chinese Academy of Sciences (nos. 2017416 and 2020353), Natural Science Foundation of Guangdong Province (no. 2018A030313873), Shenzhen ? Hong Kong Innovative Collaborative Research and Development Program (no. 9240014), Guangdong ? Hong Kong Technology Cooperation Funding Scheme (no. GHP/085/18SZ), as well as Hong Kong Research Grants Council General Research Funds (no. CityU 11205617).
Publisher Copyright:
© 2021 Acta Materialia Inc.
Keywords:
Corrosion resistance, Grain-refinement, Inflammatory responses, Ion release, Orthopedic/dental implants, Ti-45Nb alloy
Identifiers
Local EPrints ID: 448863
URI: http://eprints.soton.ac.uk/id/eprint/448863
ISSN: 1742-7061
PURE UUID: 9e0c7009-28c4-462f-bb3d-21ede2004e52
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Date deposited: 07 May 2021 16:31
Last modified: 17 Mar 2024 06:33
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Author:
Nan Hu
Author:
Lingxia Xie
Author:
Huaiyu Wang
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