A method for the growth of uniform silica shells on different size and morphology upconversion nanoparticles
A method for the growth of uniform silica shells on different size and morphology upconversion nanoparticles
Lanthanide-doped upconversion nanoparticles have emerged as attractive candidates for biomedical applications. This is due to their excitation and emission wavelengths, which lay the foundation for deeper penetration depth into biological tissue, higher resolution due to reduced scattering and improved imaging contrast as a result of a decrease in autofluorescence background. Usually, their encapsulation within a biocompatible silica shell is a requirement for their dispersion within complex media or for further functionalization of the upconversion nanoparticle surface. However, the creation of a silica shell around upconversion nanoparticles can be often challenging, many times resulting in partial silica coating or nanoparticle aggregation, as well as the production of a large number of silica particles as a side product. In this work we demonstrate a method to accurately predict the experimental conditions required to form a high yield of silica-coated upconversion nanoparticles, regardless of their shape and size.
3522-3529
Urena Horno, Elena
25a09893-6a2e-4930-99bb-1812ee7d0a03
Kyriazi, Maria-Eleni
3cfe9662-4e7f-49bc-b707-ccc2b4da6b09
Kanaras, Antonios
667ecfdc-7647-4bd8-be03-a47bf32504c7
21 June 2021
Urena Horno, Elena
25a09893-6a2e-4930-99bb-1812ee7d0a03
Kyriazi, Maria-Eleni
3cfe9662-4e7f-49bc-b707-ccc2b4da6b09
Kanaras, Antonios
667ecfdc-7647-4bd8-be03-a47bf32504c7
Urena Horno, Elena, Kyriazi, Maria-Eleni and Kanaras, Antonios
(2021)
A method for the growth of uniform silica shells on different size and morphology upconversion nanoparticles.
Nanoscale Advances, 3 (12), .
(doi:10.1039/d0na00858c).
Abstract
Lanthanide-doped upconversion nanoparticles have emerged as attractive candidates for biomedical applications. This is due to their excitation and emission wavelengths, which lay the foundation for deeper penetration depth into biological tissue, higher resolution due to reduced scattering and improved imaging contrast as a result of a decrease in autofluorescence background. Usually, their encapsulation within a biocompatible silica shell is a requirement for their dispersion within complex media or for further functionalization of the upconversion nanoparticle surface. However, the creation of a silica shell around upconversion nanoparticles can be often challenging, many times resulting in partial silica coating or nanoparticle aggregation, as well as the production of a large number of silica particles as a side product. In this work we demonstrate a method to accurately predict the experimental conditions required to form a high yield of silica-coated upconversion nanoparticles, regardless of their shape and size.
More information
Accepted/In Press date: 30 April 2021
Published date: 21 June 2021
Additional Information:
Funding Information:
AK would like to thank the BBSRC (BB/N021150/1) for funding of this project. EUH thanks the School of Physics and Astronomy for a Mayower PhD studentship.
Publisher Copyright:
© The Royal Society of Chemistry 2021.
Identifiers
Local EPrints ID: 448954
URI: http://eprints.soton.ac.uk/id/eprint/448954
ISSN: 2516-0230
PURE UUID: 380fbd7b-2ef8-4932-91f4-0c1743a12727
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Date deposited: 11 May 2021 17:11
Last modified: 17 Mar 2024 03:12
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Author:
Elena Urena Horno
Author:
Maria-Eleni Kyriazi
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