The University of Southampton
University of Southampton Institutional Repository
Warning ePrints Soton is experiencing an issue with some file downloads not being available. We are working hard to fix this. Please bear with us.

Diversity of transcriptomic microglial phenotypes in aging and Alzheimer’s disease

Diversity of transcriptomic microglial phenotypes in aging and Alzheimer’s disease
Diversity of transcriptomic microglial phenotypes in aging and Alzheimer’s disease
The morphological plasticity of microglia has fascinated neuroscientists for 100 years. Attempts to classify functional phenotypes are hampered by similarities between endogenous brain microglia and peripheral myeloid cells that can enter the brain under pathological conditions. Recent advances in single cell -omic methodologies have led to an explosion of data regarding gene expression in microglia. Herein, we review the diversity of microglial phenotypes in healthy brain, aging and Alzheimer’s disease, identify knowledge gaps in the body of evidence and suggest areas where new knowledge would be useful. Data from human samples and mouse models are compared and contrasted. Understanding the molecular complexity of the microglial response repertoire will suggest new avenues for therapeutic treatments in Alzheimer’s disease.
1552-5260
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Gordon, Marcia
a31c77ed-83cc-4681-bba5-e7249b91a5e6
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Gordon, Marcia
a31c77ed-83cc-4681-bba5-e7249b91a5e6

Boche, Delphine and Gordon, Marcia (2021) Diversity of transcriptomic microglial phenotypes in aging and Alzheimer’s disease. Alzheimer's & Dementia, [ADJ-D-20-01327R2].

Record type: Review

Abstract

The morphological plasticity of microglia has fascinated neuroscientists for 100 years. Attempts to classify functional phenotypes are hampered by similarities between endogenous brain microglia and peripheral myeloid cells that can enter the brain under pathological conditions. Recent advances in single cell -omic methodologies have led to an explosion of data regarding gene expression in microglia. Herein, we review the diversity of microglial phenotypes in healthy brain, aging and Alzheimer’s disease, identify knowledge gaps in the body of evidence and suggest areas where new knowledge would be useful. Data from human samples and mouse models are compared and contrasted. Understanding the molecular complexity of the microglial response repertoire will suggest new avenues for therapeutic treatments in Alzheimer’s disease.

Text
Boche and Gordon submission 3 clean copy
Restricted to Repository staff only
Request a copy

More information

Published date: 2 May 2021

Identifiers

Local EPrints ID: 448989
URI: http://eprints.soton.ac.uk/id/eprint/448989
ISSN: 1552-5260
PURE UUID: c6c99380-e538-4c32-897d-da52b9e4816a
ORCID for Delphine Boche: ORCID iD orcid.org/0000-0002-5884-130X

Catalogue record

Date deposited: 12 May 2021 16:49
Last modified: 13 May 2021 01:38

Export record

Contributors

Author: Delphine Boche ORCID iD
Author: Marcia Gordon

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×