Development and validation of the ISARIC 4C deterioration model for adults hospitalised with COVID-19: a prospective cohort study

e-pub ahead of print date: 11 January 2021

Published date: April 2021

Additional Information: Funding Information: This work uses data provided by patients and collected by the NHS as part of their care and support. We are extremely grateful to the 2648 front-line NHS clinical and research staff and volunteer medical students who collected this data in challenging circumstances; and the generosity of the participants and their families for their individual contributions in these difficult times. We also acknowledge the support of Jeremy J Farrar (Wellcome Trust) and Nahoko Shindo (WHO). This work is supported by grants from the NIHR (award CO-CIN-01); the MRC (grant MC_PC_19059); the NIHR HPRU in Emerging and Zoonotic Infections at the University of Liverpool, in partnership with Public Health England (PHE), in collaboration with the Liverpool School of Tropical Medicine and the University of Oxford (award 200907); the NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927); the Wellcome Trust and Department for International Development (215091/Z/18/Z); the Bill & Melinda Gates Foundation (OPP1209135); the Liverpool Experimental Cancer Medicine Centre (grant reference C18616/A25153); the NIHR BRC at Imperial College London (IS-BRC-1215–20013); the EU Platform for European Preparedness Against (Re-)emerging Epidemics (FP7 project 602525); and the NIHR Clinical Research Network, who provided infrastructure support for this research. RKG is funded by the NIHR (DRF-2018-11-ST2-004). IA acknowledges NIHR Senior Investigator Award (NF-SI-0616-10037) funding. ML acknowledges NIHR funding (HTA 16/88/06). PJMO is supported by an NIHR senior investigator award (201385). LT is supported by the Wellcome Trust (award 205228/Z/16/Z). MN is funded by a Wellcome Trust investigator award (207511/Z/17/Z) and the NIHR University College London Hospitals BRC. The views expressed in this Article are those of the authors and not necessarily those of the DHSC, Department for International Development, NIHR, MRC, Wellcome Trust, or PHE. Funding Information: ABD reports grants from the UK Department of Health and Social Care (DHSC) during the conduct of the study and grants from Wellcome Trust outside of the submitted work. CAG reports grants from the DHSC NIHR during the conduct of the study. PWH reports grants from the Wellcome Trust, Department for International Development, Bill & Melinda Gates Foundation, and NIHR during the conduct of the study. JSN-V-T reports grants from DHSC, during the conduct of the study, and is seconded to DHSC. MN is supported by a Wellcome Trust investigator award and the NIHR University College London Hospitals Biomedical Research Centre (BRC). PJMO reports personal fees from consultancies and from the European Respiratory Society, grants from the UK Medical Research Council (MRC), MRC Global Challenge Research Fund, EU, NIHR BRC, MRC/GSK, Wellcome Trust, NIHR (Health Protection Research Unit [HPRU] in Respiratory Infection), and is an NIHR senior investigator outside of the submitted work; his role as President of the British Society for Immunology was unpaid but travel and accommodation at some meetings was provided by the Society. JKB reports grants from the MRC. MGS reports grants from the DHSC NIHR, MRC, and the HPRU in Emerging and Zoonotic Infections, University of Liverpool, during the conduct of the study; and is chair of the scientific advisory board and a minority share holder at Integrum Scientific (Greensboro, NC, USA) outside of the submitted work. LT reports grants from the HPRU in Emerging and Zoonotic Infections, University of Liverpool, during the conduct of the study, and grants from Wellcome Trust outside of the submitted work. All other authors declare no competing interests. Funding Information: This work uses data provided by patients and collected by the NHS as part of their care and support. We are extremely grateful to the 2648 front-line NHS clinical and research staff and volunteer medical students who collected this data in challenging circumstances; and the generosity of the participants and their families for their individual contributions in these difficult times. We also acknowledge the support of Jeremy J Farrar (Wellcome Trust) and Nahoko Shindo (WHO). This work is supported by grants from the NIHR (award CO-CIN-01); the MRC (grant MC_PC_19059); the NIHR HPRU in Emerging and Zoonotic Infections at the University of Liverpool, in partnership with Public Health England (PHE), in collaboration with the Liverpool School of Tropical Medicine and the University of Oxford (award 200907); the NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927); the Wellcome Trust and Department for International Development (215091/Z/18/Z); the Bill & Melinda Gates Foundation (OPP1209135); the Liverpool Experimental Cancer Medicine Centre (grant reference C18616/A25153); the NIHR BRC at Imperial College London (IS-BRC-1215?20013); the EU Platform for European Preparedness Against (Re-)emerging Epidemics (FP7 project 602525); and the NIHR Clinical Research Network, who provided infrastructure support for this research. RKG is funded by the NIHR (DRF-2018-11-ST2-004). IA acknowledges NIHR Senior Investigator Award (NF-SI-0616-10037) funding. ML acknowledges NIHR funding (HTA 16/88/06). PJMO is supported by an NIHR senior investigator award (201385). LT is supported by the Wellcome Trust (award 205228/Z/16/Z). MN is funded by a Wellcome Trust investigator award (207511/Z/17/Z) and the NIHR University College London Hospitals BRC. The views expressed in this Article are those of the authors and not necessarily those of the DHSC, Department for International Development, NIHR, MRC, Wellcome Trust, or PHE. Publisher Copyright: © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

Local EPrints ID: 449148

URI: http://eprints.soton.ac.uk/id/eprint/449148

DOI: doi:10.1016/S2213-2600(20)30559-2

ISSN: 2213-2600

PURE UUID: a28d3d32-2040-4bab-8cc1-761c86c3b1ea

ORCID for Ahilanandan Dushianthan: orcid.org/0000-0002-0165-3359

Date deposited: 18 May 2021 16:31

Last modified: 16 Apr 2024 01:54