The University of Southampton
University of Southampton Institutional Repository

Allogenic haematopoietic cell transplantation for myelofibrosis: proposed definitions and management strategies for graft failure, poor graft function and relapse: best practice recommendations of the EBMT Chronic Malignancies Working Party

Allogenic haematopoietic cell transplantation for myelofibrosis: proposed definitions and management strategies for graft failure, poor graft function and relapse: best practice recommendations of the EBMT Chronic Malignancies Working Party
Allogenic haematopoietic cell transplantation for myelofibrosis: proposed definitions and management strategies for graft failure, poor graft function and relapse: best practice recommendations of the EBMT Chronic Malignancies Working Party
Allogeneic Haematopoietic Cell Transplantation (allo-HCT) remains the only curative approach in Myelofibrosis (MF). Despite advances over recent decades, relapse and non-relapse mortality rates remain significant. Relapse rates vary between 15% and 25% across retrospective studies and management strategies vary widely, ranging from palliation to adoptive immunotherapy and, in some cases, a second allo-HCT. Moreover, in allo-HCT, there is a higher incidence of poor graft function and graft failure due to splenomegaly and a hostile ‘pro-inflammatory’ marrow niche. The Practice Harmonisation and Guidelines subcommittee of the Chronic Malignancies Working Party (CMWP) of EBMT convened an international panel consisting of transplant haematologists, histopathologists and molecular biologists to propose practical, clinically relevant definitions of graft failure, poor graft function and relapse as well as management strategies following allo-HCT. A systematic approach to molecular monitoring, histopathological assessment and chimerism testing is proposed. These proposed recommendations aim to increase the accuracy and uniformity of reporting and to thereby facilitate the development of more consistent approaches to these challenging issues. In addition, we propose management strategies for these complications.
0887-6924
2445-2459
Mclornan, Donal P.
25a8b0c7-de6b-4b40-bf70-e2db5ecf4002
Hernandez Boluda, Juan Carlos
ed9707fd-4e15-4903-8b35-4dc14c0ea735
Czerw, Tomasz
4a9bf539-9ebd-4e9a-b751-f14f07946629
Cross, Nicholas
f87650da-b908-4a34-b31b-d62c5f186fe4
Deeg, H.J.
e9db65d8-df4c-450f-95d7-f974657e5502
Ditschkowski, Marcus
69f4f3f0-a8ca-42c6-be93-f417cd7154d0
Moonim, M.
0f75783d-c131-4a79-8462-10ccc9174a8d
Polverelli, Nicola
e8d70d09-d373-4115-8d09-b80c2589f284
Robin, Marie
50defd60-1c46-4931-b342-bf488eb0a4ae
Aljurf, Mahmoud
c112b685-9888-4c66-9b3e-85a691c88084
Conneally, Eibhlin
807c5f5e-5cc6-46f1-bf1d-075d3e229a1c
Hayden, Patrick
d5e2e7c2-da6f-4a04-b9f6-8963fc20924f
Yakoub-Agha, Ibrahim
7f01d81f-64a9-49e5-8ade-df0976a0bf51
Mclornan, Donal P.
25a8b0c7-de6b-4b40-bf70-e2db5ecf4002
Hernandez Boluda, Juan Carlos
ed9707fd-4e15-4903-8b35-4dc14c0ea735
Czerw, Tomasz
4a9bf539-9ebd-4e9a-b751-f14f07946629
Cross, Nicholas
f87650da-b908-4a34-b31b-d62c5f186fe4
Deeg, H.J.
e9db65d8-df4c-450f-95d7-f974657e5502
Ditschkowski, Marcus
69f4f3f0-a8ca-42c6-be93-f417cd7154d0
Moonim, M.
0f75783d-c131-4a79-8462-10ccc9174a8d
Polverelli, Nicola
e8d70d09-d373-4115-8d09-b80c2589f284
Robin, Marie
50defd60-1c46-4931-b342-bf488eb0a4ae
Aljurf, Mahmoud
c112b685-9888-4c66-9b3e-85a691c88084
Conneally, Eibhlin
807c5f5e-5cc6-46f1-bf1d-075d3e229a1c
Hayden, Patrick
d5e2e7c2-da6f-4a04-b9f6-8963fc20924f
Yakoub-Agha, Ibrahim
7f01d81f-64a9-49e5-8ade-df0976a0bf51

Mclornan, Donal P., Hernandez Boluda, Juan Carlos, Czerw, Tomasz, Cross, Nicholas, Deeg, H.J., Ditschkowski, Marcus, Moonim, M., Polverelli, Nicola, Robin, Marie, Aljurf, Mahmoud, Conneally, Eibhlin, Hayden, Patrick and Yakoub-Agha, Ibrahim (2021) Allogenic haematopoietic cell transplantation for myelofibrosis: proposed definitions and management strategies for graft failure, poor graft function and relapse: best practice recommendations of the EBMT Chronic Malignancies Working Party. Leukemia, 35 (9), 2445-2459. (doi:10.1038/s41375-021-01294-2).

Record type: Review

Abstract

Allogeneic Haematopoietic Cell Transplantation (allo-HCT) remains the only curative approach in Myelofibrosis (MF). Despite advances over recent decades, relapse and non-relapse mortality rates remain significant. Relapse rates vary between 15% and 25% across retrospective studies and management strategies vary widely, ranging from palliation to adoptive immunotherapy and, in some cases, a second allo-HCT. Moreover, in allo-HCT, there is a higher incidence of poor graft function and graft failure due to splenomegaly and a hostile ‘pro-inflammatory’ marrow niche. The Practice Harmonisation and Guidelines subcommittee of the Chronic Malignancies Working Party (CMWP) of EBMT convened an international panel consisting of transplant haematologists, histopathologists and molecular biologists to propose practical, clinically relevant definitions of graft failure, poor graft function and relapse as well as management strategies following allo-HCT. A systematic approach to molecular monitoring, histopathological assessment and chimerism testing is proposed. These proposed recommendations aim to increase the accuracy and uniformity of reporting and to thereby facilitate the development of more consistent approaches to these challenging issues. In addition, we propose management strategies for these complications.

Text
Final version - Accepted Manuscript
Download (433kB)

More information

Accepted/In Press date: 7 May 2021
Published date: September 2021
Additional Information: Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature Limited.

Identifiers

Local EPrints ID: 449197
URI: http://eprints.soton.ac.uk/id/eprint/449197
ISSN: 0887-6924
PURE UUID: 08bbc369-f73b-4a5b-be02-4da4eaaeeb93
ORCID for Nicholas Cross: ORCID iD orcid.org/0000-0001-5481-2555

Catalogue record

Date deposited: 19 May 2021 18:15
Last modified: 17 Mar 2024 06:33

Export record

Altmetrics

Contributors

Author: Donal P. Mclornan
Author: Juan Carlos Hernandez Boluda
Author: Tomasz Czerw
Author: Nicholas Cross ORCID iD
Author: H.J. Deeg
Author: Marcus Ditschkowski
Author: M. Moonim
Author: Nicola Polverelli
Author: Marie Robin
Author: Mahmoud Aljurf
Author: Eibhlin Conneally
Author: Patrick Hayden
Author: Ibrahim Yakoub-Agha

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×