Medical algorithm: Early introduction of food allergens in high-risk populations
Medical algorithm: Early introduction of food allergens in high-risk populations
Oral Tolerance Induction (OTI) is the only RCT-proven effective intervention for preventing childhood food allergy.(1, 2) OTI to peanut is highly effective in a high-risk population with an 81% relative risk ration (RRR) to peanut allergy .(3) OTI also reduced egg allergy in the general population in a per protocol analysis.(1) These published RCT findings have changed practice and many governmental and allergy societies now recommend introducing peanut in infancy; some suggest that other foods, such as well-cooked egg, are also introduced. Only National Institute of Allergy and Infectious Diseases (NIAID) stratify their recommendations according to food allergy (FA) risk level.
allergy diagnosis, atopic dermatitis, challenge tests, complementary feeding, food allergy, pediatrics, prevention, weaning
1592-1594
Fisher, Helen R
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Lack, Gideon
cac030a2-c358-4880-a91d-d67d06e8e321
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Bahnson, Henry T
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Du Toit, George
7930b820-e6f7-4c4c-866c-4334017d1106
May 2021
Fisher, Helen R
0120c9ec-635f-4c74-9619-200842a2a39e
Lack, Gideon
cac030a2-c358-4880-a91d-d67d06e8e321
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Bahnson, Henry T
2ecc6945-97fd-46bc-8d46-42606d4ccfe0
Du Toit, George
7930b820-e6f7-4c4c-866c-4334017d1106
Fisher, Helen R, Lack, Gideon, Roberts, Graham, Bahnson, Henry T and Du Toit, George
(2021)
Medical algorithm: Early introduction of food allergens in high-risk populations.
Allergy, 76 (5), .
(doi:10.1111/all.14717).
Abstract
Oral Tolerance Induction (OTI) is the only RCT-proven effective intervention for preventing childhood food allergy.(1, 2) OTI to peanut is highly effective in a high-risk population with an 81% relative risk ration (RRR) to peanut allergy .(3) OTI also reduced egg allergy in the general population in a per protocol analysis.(1) These published RCT findings have changed practice and many governmental and allergy societies now recommend introducing peanut in infancy; some suggest that other foods, such as well-cooked egg, are also introduced. Only National Institute of Allergy and Infectious Diseases (NIAID) stratify their recommendations according to food allergy (FA) risk level.
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e-pub ahead of print date: 21 December 2020
Published date: May 2021
Additional Information:
Funding Information:
Dr. Fisher reports grants from NIAID ITN, during the conduct of the study; personal fees from Aimmune Therapeutics, outside the submitted work; Dr. Lack reports grants from National Institute of Allergy and InfectiousÝiseases (NIAID, NIH), other from Food Allergy & Research Education (FARE), other from MRC & Asthma UK Centre, other from UK Dept of Health through NIHR, other from National Peanut Board (NPB), grants from UK Food Standards Agency (FSA), grants from Action Medical Research, during the conduct of the study; other from DBV Technologies, other from Mighty Mission Me, personal fees from Novartis, personal fees from Sanofi‐Genzyme, personal fees from Regeneron, personal fees from ALK‐Abello, outside the submitted work; Dr. Roberts reports grants from National Institutes of Health, outside the submitted work; and Coordinator of the EAACI Food Allergy Prevention Guideline; Henry Bahnson reports personal fees from King's College London, during the conduct of the study; grants from Immune Tolerance Network, grants from DBV Technologies, outside the submitted work; Dr. Du Toit reports income from grants from National Institute of Allergy and Infectious Diseases (NIAID, NIH), Food Allergy & Research Education (FARE), MRC & Asthma UK Centre, UK Dept of Health through NIHR and National Peanut Board (NPB).
Keywords:
allergy diagnosis, atopic dermatitis, challenge tests, complementary feeding, food allergy, pediatrics, prevention, weaning
Identifiers
Local EPrints ID: 449221
URI: http://eprints.soton.ac.uk/id/eprint/449221
ISSN: 0105-4538
PURE UUID: 3cca9993-904f-4626-9896-44eef1453fa7
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Date deposited: 19 May 2021 18:20
Last modified: 17 Mar 2024 03:01
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Contributors
Author:
Helen R Fisher
Author:
Gideon Lack
Author:
Henry T Bahnson
Author:
George Du Toit
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