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Data from: Tracing the rise of malignant cell lines: distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils

Data from: Tracing the rise of malignant cell lines: distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils
Data from: Tracing the rise of malignant cell lines: distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils
Emerging infectious diseases are rising globally and understanding host-pathogen interactions during the initial stages of disease emergence is essential for assessing potential evolutionary dynamics and designing novel management strategies. Tasmanian devils (Sarcophilus harrisii) are endangered due to a transmissible cancer – devil facial tumour disease (DFTD) – that since its emergence in the 1990’s, has affected most populations throughout Tasmania. Recent studies suggest that devils are adapting to the DFTD epidemic and that disease-induced extinction is unlikely. However, in 2014 a second and independently evolved transmissible cancer – devil facial tumour 2 (DFT2) – was discovered at the d’Entrecasteaux peninsula, in southeast Tasmania, suggesting that the species is prone to transmissible cancers. To date, there is little information about the distribution, epidemiology and effects of DFT2 and its interaction with DFTD. Here we use data from monitoring surveys and road-kills found within and adjacent to the d’Entrecasteaux peninsula to determine the distribution of both cancers and to compare their epidemiological patterns. Since 2012, a total of 51 DFTD tumours have been confirmed among 26 individuals inside the peninsula and its surroundings, while 40 DFT2 tumours have been confirmed among 23 individuals, and two individuals co-infected with both tumours . All devils with DFT2 were found within the d’Entrecasteaux peninsula, suggesting that this new transmissible cancer is geographically confined to this area. We found significant differences in tumour bodily location in DFTD and DFT2, with non-facial tumours more commonly found in DFT2. There was a significant sex bias in DFT2, with most cases reported in males, suggesting that since DFT2 originated from a male host, females might be less susceptible to this cancer. We discuss the implications of our results for understanding the epidemiological and evolutionary interactions of these two contemporary transmissible cancers and evaluating the effectiveness of potential management strategies.,Devil_tumour_metadataInformation on diseased animalsDryad_data_devil_tumour.csv,
DRYAD
James, Samantha
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Jennings, Geordie
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Kwon, Young Mi
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Stammnitz, Maximilian
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Fraik, Alexandra
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Storfer, Andrew
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Comte, Sebastien
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Pemberton, David
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Fox, Samantha
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Brown, Bill
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Pye, Ruth
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Woods, Gregory
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Lyons, Bruce
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Hohenlohe, Paul
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McCallum, Hamish
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Siddle, Hannah V.
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Thomas, Frederic
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Ujvari, Beata
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Murchison, Elizabeth P.
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Jones, Menna
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Hamede, Rodrigo
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James, Samantha
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Jennings, Geordie
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Kwon, Young Mi
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Stammnitz, Maximilian
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Fraik, Alexandra
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Storfer, Andrew
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Comte, Sebastien
f13fc974-8d2b-4e28-965a-22167bdd351f
Pemberton, David
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Fox, Samantha
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Brown, Bill
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Pye, Ruth
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Woods, Gregory
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Lyons, Bruce
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Hohenlohe, Paul
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McCallum, Hamish
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Siddle, Hannah V.
2f0c1307-55d3-4965-a8b0-495c4a799f27
Thomas, Frederic
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Ujvari, Beata
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Murchison, Elizabeth P.
ae566d4f-04c6-4382-a519-9e45e0505a92
Jones, Menna
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Hamede, Rodrigo
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James, Samantha, Jennings, Geordie, Kwon, Young Mi, Stammnitz, Maximilian, Fraik, Alexandra, Storfer, Andrew, Comte, Sebastien, Fox, Samantha, Brown, Bill, Pye, Ruth, Woods, Gregory, Lyons, Bruce, Hohenlohe, Paul, McCallum, Hamish, Ujvari, Beata, Murchison, Elizabeth P., Jones, Menna and Hamede, Rodrigo (2019) Data from: Tracing the rise of malignant cell lines: distribution, epidemiology and evolutionary interactions of two transmissible cancers in Tasmanian devils. DRYAD doi:10.5061/dryad.jj83827 [Dataset]

Record type: Dataset

Abstract

Emerging infectious diseases are rising globally and understanding host-pathogen interactions during the initial stages of disease emergence is essential for assessing potential evolutionary dynamics and designing novel management strategies. Tasmanian devils (Sarcophilus harrisii) are endangered due to a transmissible cancer – devil facial tumour disease (DFTD) – that since its emergence in the 1990’s, has affected most populations throughout Tasmania. Recent studies suggest that devils are adapting to the DFTD epidemic and that disease-induced extinction is unlikely. However, in 2014 a second and independently evolved transmissible cancer – devil facial tumour 2 (DFT2) – was discovered at the d’Entrecasteaux peninsula, in southeast Tasmania, suggesting that the species is prone to transmissible cancers. To date, there is little information about the distribution, epidemiology and effects of DFT2 and its interaction with DFTD. Here we use data from monitoring surveys and road-kills found within and adjacent to the d’Entrecasteaux peninsula to determine the distribution of both cancers and to compare their epidemiological patterns. Since 2012, a total of 51 DFTD tumours have been confirmed among 26 individuals inside the peninsula and its surroundings, while 40 DFT2 tumours have been confirmed among 23 individuals, and two individuals co-infected with both tumours . All devils with DFT2 were found within the d’Entrecasteaux peninsula, suggesting that this new transmissible cancer is geographically confined to this area. We found significant differences in tumour bodily location in DFTD and DFT2, with non-facial tumours more commonly found in DFT2. There was a significant sex bias in DFT2, with most cases reported in males, suggesting that since DFT2 originated from a male host, females might be less susceptible to this cancer. We discuss the implications of our results for understanding the epidemiological and evolutionary interactions of these two contemporary transmissible cancers and evaluating the effectiveness of potential management strategies.,Devil_tumour_metadataInformation on diseased animalsDryad_data_devil_tumour.csv,

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More information

Published date: 1 January 2019

Identifiers

Local EPrints ID: 449261
URI: http://eprints.soton.ac.uk/id/eprint/449261
PURE UUID: 2d83adb4-c0b3-47c8-a7c9-d84e000a3663

Catalogue record

Date deposited: 20 May 2021 16:34
Last modified: 20 May 2021 16:35

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Contributors

Creator: Samantha James
Creator: Geordie Jennings
Creator: Young Mi Kwon
Creator: Maximilian Stammnitz
Creator: Alexandra Fraik
Creator: Andrew Storfer
Creator: Sebastien Comte
Contributor: David Pemberton
Creator: Samantha Fox
Creator: Bill Brown
Creator: Ruth Pye
Creator: Gregory Woods
Creator: Bruce Lyons
Creator: Paul Hohenlohe
Creator: Hamish McCallum
Contributor: Hannah V. Siddle
Contributor: Frederic Thomas
Creator: Beata Ujvari
Creator: Elizabeth P. Murchison
Creator: Menna Jones
Creator: Rodrigo Hamede

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