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Data from: Epigenome-wide association study of lung function level and its change

Data from: Epigenome-wide association study of lung function level and its change
Data from: Epigenome-wide association study of lung function level and its change
statistical_codescontains the statistical codes used to: 1- derive residuals of methylation data ; 2a - run EWAS cross-sectionally; 2b - run EWAS as repeated cross-sectional analysis; 2c - run EWAS predictive association with change in outcome; 3a - meta-analysis script for replication ; 3b - combined discovery and replication meta-analysis script.DiscoveryResultsByCohorts_archive.tarThis archive contains all the cohort-specific discovery EWAS results. See read-me file for details.DiscoveryResultsByCohorts.tar.gzDiscoveryMetaResults_archive.tarThis archive contains all the discovery EWAS meta-analysed results. See read-me file for details.DiscoveryMetaResults.tar.gzReplicationResultsByCohorts.tarThis archive contains all the cohort-specific replication results. See read-me file for details.ReplicationMetaResults.tarThis archive contains all the replication meta-analysed results. See read-me file for details.CombinedMetaResults.tarThis archive contains the discovery cohort and replication cohort combined meta-analysed results. See read-me file for details.ChildhoodMetaResults.tarThis archive contains all the childhood cohort replication meta-analysed results. See read-me file for details.,Previous reports link differential DNA methylation (DNAme) to environmental exposures which are associated with lung function. Direct evidence on lung function DNAme is however limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults. In a discovery-replication EWAS design, DNAme in blood and spirometry were measured twice, six-to-15 years apart, in the same participants of three adult population-based discovery cohorts (n=2,043). Associated DNAme markers (P
DRYAD
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(2019) Data from: Epigenome-wide association study of lung function level and its change. DRYAD doi:10.5061/dryad.pr10c20 [Dataset]

Record type: Dataset

Abstract

statistical_codescontains the statistical codes used to: 1- derive residuals of methylation data ; 2a - run EWAS cross-sectionally; 2b - run EWAS as repeated cross-sectional analysis; 2c - run EWAS predictive association with change in outcome; 3a - meta-analysis script for replication ; 3b - combined discovery and replication meta-analysis script.DiscoveryResultsByCohorts_archive.tarThis archive contains all the cohort-specific discovery EWAS results. See read-me file for details.DiscoveryResultsByCohorts.tar.gzDiscoveryMetaResults_archive.tarThis archive contains all the discovery EWAS meta-analysed results. See read-me file for details.DiscoveryMetaResults.tar.gzReplicationResultsByCohorts.tarThis archive contains all the cohort-specific replication results. See read-me file for details.ReplicationMetaResults.tarThis archive contains all the replication meta-analysed results. See read-me file for details.CombinedMetaResults.tarThis archive contains the discovery cohort and replication cohort combined meta-analysed results. See read-me file for details.ChildhoodMetaResults.tarThis archive contains all the childhood cohort replication meta-analysed results. See read-me file for details.,Previous reports link differential DNA methylation (DNAme) to environmental exposures which are associated with lung function. Direct evidence on lung function DNAme is however limited. We undertook an agnostic epigenome-wide association study (EWAS) on pre-bronchodilation lung function and its change in adults. In a discovery-replication EWAS design, DNAme in blood and spirometry were measured twice, six-to-15 years apart, in the same participants of three adult population-based discovery cohorts (n=2,043). Associated DNAme markers (P

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Published date: 1 January 2019
Related URLs:
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Identifiers

Local EPrints ID: 449320
URI: http://eprints.soton.ac.uk/id/eprint/449320
DOI: doi:10.5061/dryad.pr10c20
PURE UUID: 1be7a152-5fbd-44c6-9cf5-d43b5a395170
ORCID for Faisal I Rezwan: ORCID iD orcid.org/0000-0001-9921-222X
ORCID for John W Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 24 May 2021 16:32
Last modified: 20 Jul 2023 01:42

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Contributors

Contributor: Medea Imboden
Contributor: Matthias Wielscher
Contributor: Faisal I Rezwan ORCID iD
Contributor: Andre F S Amaral
Contributor: Emmanuel Schaffner
Contributor: Ayoung Jeong
Contributor: Anna Beckmeyer-Borowko
Contributor: Sarah E Harris
Contributor: John M Starr
Contributor: Ian J Deary
Contributor: Claudia Flexeder
Contributor: Melanie Waldenberger
Contributor: Annette Peters
Contributor: Holger Schulz
Contributor: Su Chen
Contributor: Shadia KHan Sunny
Contributor: Wilfried J J Karmaus
Contributor: Yu Jiang
Contributor: Gertraud Erhart
Contributor: Florian Kronenberg
Contributor: Ryan Arathimos
Contributor: Gemma C Sharp
Contributor: Alexander John Henderson
Contributor: Yu Fu
Contributor: Paivi Piirila
Contributor: Kirsi H Pietilainen
Contributor: Miina Ollikainen
Contributor: Asa Johannson
Contributor: Ulf Gyllensten
Contributor: Maaike De Vries
Contributor: Diana Van Der Plaat
Contributor: Kim De Jong
Contributor: Hendrika M Boezen
Contributor: Ian P Hall
Contributor: Martin D Tobin
Contributor: Marjo-Riitta Järvelin
Contributor: John W Holloway ORCID iD
Contributor: Deborah Jarvis
Contributor: Nicole M Probst-Hensch

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