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The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.

The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.
The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.
2041-1723
Acton, Richard James
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Yuan, Wei
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Gao, Fei
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Xia, Yudong
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Bourne, Emma
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Wozniak, Eva
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Bell, Jordana
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Lillycrop, Karen
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Wang, Jun
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Dennison, Elaine
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Harvey, Nicholas
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Mein, Charles A.
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Spector, Tim D.
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Hysi, Pirro G
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Cooper, Cyrus
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Bell, Christopher G.
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Acton, Richard James
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Yuan, Wei
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Gao, Fei
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Xia, Yudong
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Bourne, Emma
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Wozniak, Eva
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Bell, Jordana
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Lillycrop, Karen
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Wang, Jun
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Dennison, Elaine
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Harvey, Nicholas
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Mein, Charles A.
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Spector, Tim D.
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Hysi, Pirro G
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Cooper, Cyrus
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Bell, Christopher G.
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Acton, Richard James, Yuan, Wei, Gao, Fei, Xia, Yudong, Bourne, Emma, Wozniak, Eva, Bell, Jordana, Lillycrop, Karen, Wang, Jun, Dennison, Elaine, Harvey, Nicholas, Mein, Charles A., Spector, Tim D., Hysi, Pirro G, Cooper, Cyrus and Bell, Christopher G. (2021) The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation. Nature Communications, 12 (1), [2655]. (doi:10.1038/s41467-021-22639-6).

Record type: Article
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acton_ncomms_21_Ageing-DNAm-tRNA_ACCEPTED - Accepted Manuscript
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Accepted/In Press date: 1 March 2021
Published date: 11 May 2021
Additional Information: Acknowledgements We gratefully acknowledge the individuals from TwinsUK, Mavidos and the Hertfordshrie cohort. TwinsUK received funding from the Wellcome Trust (Ref: 081878/Z/06/Z), European Community’s Seventh Framework Programme (FP7/2007-2013), the National Institute for Health Research (NIHR)-funded BioResource, Clinical Research Facility and Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust in partnership with King’s College London. Further funding support for the EpiTwin project was obtained from the European Research Council (project number 250157) and BGI. SNP Genotyping was performed by The Wellcome Trust Sanger Institute and National Eye Institute via NIH/CIDR. The authors would like to thank Nikki Graham for her assistance with the identification and pooling of the MAVIDOS and Hertfordshire DNA samples. The authors also acknowledge the use of the IRIDIS High Performance Computing Facility, and associated support services at the University of Southampton, in the completion of this work. The MRC-LEU is supported by the Medical Research Council (MRC). R.J.A. was in receipt of a MRC Doctoral fund (1820097).

Identifiers

Local EPrints ID: 449334
URI: http://eprints.soton.ac.uk/id/eprint/449334
ISSN: 2041-1723
PURE UUID: 83aa76f4-f911-41d6-a9a3-1335f22c400b
ORCID for Richard James Acton: ORCID iD orcid.org/0000-0002-2574-9611
ORCID for Karen Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489
ORCID for Elaine Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 25 May 2021 16:32
Last modified: 24 Nov 2021 02:51

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Contributors

Author: Richard James Acton ORCID iD
Author: Wei Yuan
Author: Fei Gao
Author: Yudong Xia
Author: Emma Bourne
Author: Eva Wozniak
Author: Jordana Bell
Author: Karen Lillycrop ORCID iD
Author: Jun Wang
Author: Elaine Dennison ORCID iD
Author: Nicholas Harvey ORCID iD
Author: Charles A. Mein
Author: Tim D. Spector
Author: Pirro G Hysi
Author: Cyrus Cooper ORCID iD
Author: Christopher G. Bell

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