Endocytosis in the placenta: an undervalued mediator of placental transfer
Endocytosis in the placenta: an undervalued mediator of placental transfer
Endocytosis is an essential mechanism for cellular uptake in many human tissues. A range of endocytic mechanisms occur including clathrin-dependent and -independent mechanisms. However, the role of endocytosis in the placenta and the spatial localisation of individual mechanisms is not well understood. The two principal cell layers that comprise the placental barrier to maternal-fetal transfer are the syncytiotrophoblast and fetal capillary endothelium. Endocytic uptake into the syncytiotrophoblast has been demonstrated for physiological maternal molecules such as transferrin-bound iron and low density lipoprotein (LDL) and may play an important role in the uptake of several other micronutrients, serum proteins, and therapeutics at both major placental cell barriers. These mechanisms may also mediate placental uptake of some viruses and nanoparticles. This review introduces the mechanisms of cargo-specific endocytosis and what is known about their localisation in the placenta, focussing predominantly on the syncytiotrophoblast. A fuller understanding of placental endocytosis is necessary to explain both fetal nutrition and the properties of the placental barrier. Characterising placental endocytic mechanisms and their regulation may allow us to identify their role in pregnancy pathologies and provide new avenues for therapeutic intervention.
Albumin, Caveolin, Clathrin, Syncytiotrophoblast, TfR1, hFcRn
67-73
Cooke, Laura D F
89a0097e-fbf7-4485-a80b-1f890d824de6
Tumbarello, David A
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Harvey, Nicholas C
ce487fb4-d360-4aac-9d17-9466d6cba145
Sethi, Jaswinder K
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Lewis, Rohan M
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Cleal, Jane K
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3 May 2021
Cooke, Laura D F
89a0097e-fbf7-4485-a80b-1f890d824de6
Tumbarello, David A
75c6932e-fdbf-4d3c-bb4f-48fbbdba93a2
Harvey, Nicholas C
ce487fb4-d360-4aac-9d17-9466d6cba145
Sethi, Jaswinder K
923f1a81-91e4-46cd-8853-bb4a979f5a85
Lewis, Rohan M
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Cleal, Jane K
18cfd2c1-bd86-4a13-b38f-c321af56da66
Cooke, Laura D F, Tumbarello, David A, Harvey, Nicholas C, Sethi, Jaswinder K, Lewis, Rohan M and Cleal, Jane K
(2021)
Endocytosis in the placenta: an undervalued mediator of placental transfer.
Placenta, 113, .
(doi:10.1016/j.placenta.2021.04.014).
Abstract
Endocytosis is an essential mechanism for cellular uptake in many human tissues. A range of endocytic mechanisms occur including clathrin-dependent and -independent mechanisms. However, the role of endocytosis in the placenta and the spatial localisation of individual mechanisms is not well understood. The two principal cell layers that comprise the placental barrier to maternal-fetal transfer are the syncytiotrophoblast and fetal capillary endothelium. Endocytic uptake into the syncytiotrophoblast has been demonstrated for physiological maternal molecules such as transferrin-bound iron and low density lipoprotein (LDL) and may play an important role in the uptake of several other micronutrients, serum proteins, and therapeutics at both major placental cell barriers. These mechanisms may also mediate placental uptake of some viruses and nanoparticles. This review introduces the mechanisms of cargo-specific endocytosis and what is known about their localisation in the placenta, focussing predominantly on the syncytiotrophoblast. A fuller understanding of placental endocytosis is necessary to explain both fetal nutrition and the properties of the placental barrier. Characterising placental endocytic mechanisms and their regulation may allow us to identify their role in pregnancy pathologies and provide new avenues for therapeutic intervention.
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Accepted_Manuscript_Endocytosis_in_the_placenta
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More information
Accepted/In Press date: 27 April 2021
e-pub ahead of print date: 3 May 2021
Published date: 3 May 2021
Additional Information:
Funding Information:
LDFC is funded by the Gerald Kerkut Charitable Trust ; DAT is funded by the Wellcome Trust Seed Award ( 205909/Z/17/Z ); NCH is funded by the MRC , NIHR , Versus Athritis , BBSRC , and Wellcome Trust ; JKS is funded by the Wellcome Trust (Grant Number 206453/Z/17/Z ); RML and JKC are supported by BBSRC ( BB/R002762/1 ) and Wellbeing of Women ; RML is also funded by The Leverhulme Trust .
Publisher Copyright:
© 2021 Elsevier Ltd
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
Keywords:
Albumin, Caveolin, Clathrin, Syncytiotrophoblast, TfR1, hFcRn
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Local EPrints ID: 449571
URI: http://eprints.soton.ac.uk/id/eprint/449571
ISSN: 0143-4004
PURE UUID: 30e51285-b703-4545-bb29-db95d199e663
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Date deposited: 08 Jun 2021 16:31
Last modified: 17 Mar 2024 03:59
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Author:
Laura D F Cooke
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