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Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study
Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks’ gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth.

Biomarker, Fetal growth restriction, SGA, SPINT1
0143-4004
24 - 28
Kaitu'u-Lino, Tu'uhevaha J.
e03961ad-3a49-40e6-84a3-52a3f23455b8
Tong, Stephen
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Walker, Susan P.
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MacDonald, Teresa M.
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Cannon, Ping
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Nguyen, Tuong-Vi
bb55730f-945e-45f5-87b0-c6a74c99c4a6
Sadananthan, Suresh Anand
41601e35-0034-44a4-b37f-87fc92adfe79
Tint, Mya Thway
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Ong, Yi Ying
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Loy, See Ling
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Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Chong, Yap-Seng
492de658-aa9e-4b57-95bf-33109f4d2cc5
Godfrey, Keith
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Chan, Shiao-Yng
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Tan, Kok Hian
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Lee, Yung Seng
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Michael, Navin
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Eriksson, Johan G.
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Wlodek, Mary E.
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Kaitu'u-Lino, Tu'uhevaha J.
e03961ad-3a49-40e6-84a3-52a3f23455b8
Tong, Stephen
66c8f8f5-abd4-4049-99df-f7c509f16d8b
Walker, Susan P.
1566eadf-d050-4cb9-a56c-8984aa9ad449
MacDonald, Teresa M.
b7d57d4c-8a39-4fe8-b2ff-33464963084b
Cannon, Ping
5e8b52e4-9f62-4817-bc2f-aca07c53b0f5
Nguyen, Tuong-Vi
bb55730f-945e-45f5-87b0-c6a74c99c4a6
Sadananthan, Suresh Anand
41601e35-0034-44a4-b37f-87fc92adfe79
Tint, Mya Thway
3aaf54db-4dbd-4d6b-90ae-440a18e381ef
Ong, Yi Ying
a474cc8c-f956-4d25-a06b-c0b655347823
Loy, See Ling
6fd10b64-1de2-419e-a5f4-b505be233e6e
Gluckman, Peter D.
e916630e-5ae2-437c-a1d1-8e24c0e05589
Chong, Yap-Seng
492de658-aa9e-4b57-95bf-33109f4d2cc5
Godfrey, Keith
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Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Tan, Kok Hian
672ae6c4-d4c8-4b1b-8512-efec36431503
Lee, Yung Seng
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Michael, Navin
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Eriksson, Johan G.
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Wlodek, Mary E.
f56b571a-c420-4bfe-b3d9-c2033e1f5495

Kaitu'u-Lino, Tu'uhevaha J., Tong, Stephen, Walker, Susan P., MacDonald, Teresa M., Cannon, Ping, Nguyen, Tuong-Vi, Sadananthan, Suresh Anand, Tint, Mya Thway, Ong, Yi Ying, Loy, See Ling, Gluckman, Peter D., Chong, Yap-Seng, Godfrey, Keith, Chan, Shiao-Yng, Tan, Kok Hian, Lee, Yung Seng, Michael, Navin, Eriksson, Johan G. and Wlodek, Mary E. (2021) Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study. Placenta, 110, 24 - 28. (doi:10.1016/j.placenta.2021.05.007).

Record type: Article

Abstract

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a prospective cohort in Singapore. Circulating SPINT1 concentrations were significantly lower among 141 pregnant women destined to deliver small-for-gestational age infants (birthweight <10th centile), compared to 772 controls (p < 0.01) at as early as 26 weeks’ gestation. There were no correlations between infant body composition and circulating SPINT1 concentrations at 26 weeks. This provides validation that low maternal SPINT1 concentration is associated with poor fetal growth.

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More information

Accepted/In Press date: 26 May 2021
e-pub ahead of print date: 1 June 2021
Published date: July 2021
Additional Information: Funding Information: Funding for this work was provided by the National Health and Medical Research Council (#1065854, #1183854, #116071), National Health and Medical Research Council Fellowships to TKL (#1159261) and ST (#1136418), and the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore [NMRC/TCR/004-NUS/2008, NMRC/TCR/012-NUHS/2014]. Additional funding was provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore.TKL, TM, SW and ST hold a provisional patent (PCT/AU2019/050,516) relating to the use of SPINT1 and syndecan as diagnostic markers in pregnancy. KMG, PDG and YSC have received reimbursement for speaking at conferences sponsored by companies selling nutritional products, and is part of an academic consortium that has received research funding from Abbott Nutrition, Nestec, BenevolentAI Bio Ltd. and Danone. The remaining authors have no conflicts of interest to declare.KMG is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator (NF?SI-0515-10042), NIHR Southampton 1000DaysPlus Global Nutrition Research Group (17/63/154) and NIHR Southampton Biomedical Research Centre (IS-BRC-1215-20004)), the European Union (Erasmus+ Programme ImpENSA 598488-EPP-1-2018-1-DE-EPPKA2-CBHE-JP) and the British Heart Foundation (RG/15/17/3174). Funding Information: Funding for this work was provided by the National Health and Medical Research Council (#1065854, #1183854, #116071), National Health and Medical Research Council Fellowships to TKL (#1159261) and ST (#1136418), and the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council ( NMRC ), Singapore [ NMRC /TCR/004- NUS /2008, NMRC /TCR/012- NUHS /2014]. Additional funding was provided by the Singapore Institute for Clinical Sciences , Agency for Science Technology and Research ( A*STAR ), Singapore. Funding Information: TKL, TM, SW and ST hold a provisional patent (PCT/AU2019/050516) relating to the use of SPINT1 and syndecan as diagnostic markers in pregnancy. KMG, PDG and YSC have received reimbursement for speaking at conferences sponsored by companies selling nutritional products, and is part of an academic consortium that has received research funding from Abbott Nutrition, Nestec, BenevolentAI Bio Ltd. and Danone. The remaining authors have no conflicts of interest to declare. Funding Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
Keywords: Biomarker, Fetal growth restriction, SGA, SPINT1

Identifiers

Local EPrints ID: 449780
URI: http://eprints.soton.ac.uk/id/eprint/449780
ISSN: 0143-4004
PURE UUID: 8e6267ef-0867-4532-97ce-5ba4b41b7b62
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 17 Jun 2021 16:30
Last modified: 26 Nov 2021 02:35

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Contributors

Author: Tu'uhevaha J. Kaitu'u-Lino
Author: Stephen Tong
Author: Susan P. Walker
Author: Teresa M. MacDonald
Author: Ping Cannon
Author: Tuong-Vi Nguyen
Author: Suresh Anand Sadananthan
Author: Mya Thway Tint
Author: Yi Ying Ong
Author: See Ling Loy
Author: Peter D. Gluckman
Author: Yap-Seng Chong
Author: Keith Godfrey ORCID iD
Author: Shiao-Yng Chan
Author: Kok Hian Tan
Author: Yung Seng Lee
Author: Navin Michael
Author: Johan G. Eriksson
Author: Mary E. Wlodek

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