Bilateral permanent childhood hearing loss and health-related quality of life in adolescence
Bilateral permanent childhood hearing loss and health-related quality of life in adolescence
Little is known about the impact of bilateral permanent childhood hearing loss (PCHL) on health-related quality of life (HRQoL). The objective of this study was to describe preference-based and non-preference based HRQoL outcomes in adolescence, from both self and proxy perspectives, amongst participants of the Hearing Outcomes Project. The Health Utilities Index Marks II (HUI2) and III (HUI3) and the PedsQL™ Version 4.0 Generic Core Scales were used to measure HRQoL based on self and parent proxy reports in 114 adolescents aged 13–19 years, 76 with bilateral PCHL and 38 with normal hearing, recruited from a population sample that was followed up from birth to adolescence. Descriptive statistics and multivariable analyses were used to estimate the relationship between severity of PCHL and HRQoL outcomes. PCHL was associated with decrements in mean multi-attribute utility score that varied between 0.078 and 0.148 for the HUI2 (p = 0.001) and between 0.205 and 0.315 for the HUI3 (p < 0.001), dependent upon the national tariff set applied and respondent group. Multivariable analyses revealed that, after controlling for clinical and sociodemographic covariates, mean HUI3 multi-attribute utility scores were significantly lower in adolescents with moderately severe, severe and profound hearing loss than in adolescents with normal hearing. Significant differences in physical functioning, social functioning, psychosocial functioning and total PedsQL™ scores were only observed when assessments by parents were relied upon, but these dissipated in the multivariable analyses. Bilateral PCHL is associated with poorer HRQoL outcomes in adolescence. Further studies conducted are needed to understand the trajectory and underpinning mechanisms of HRQoL outcomes following PCHL.
Adolescence, Health utilities index, Health-related quality of life, Permanent childhood hearing loss, Preferences
Petrou, Stavros
5ee930f5-99db-4fb8-b401-95584cff0e20
Khan, Kamran
f55abc91-5af0-4175-a845-90e88ab2e45a
Kennedy, Colin
7c3aff62-0a86-4b44-b7d7-4bc01f23ec93
7 June 2021
Petrou, Stavros
5ee930f5-99db-4fb8-b401-95584cff0e20
Khan, Kamran
f55abc91-5af0-4175-a845-90e88ab2e45a
Kennedy, Colin
7c3aff62-0a86-4b44-b7d7-4bc01f23ec93
Petrou, Stavros, Khan, Kamran and Kennedy, Colin
(2021)
Bilateral permanent childhood hearing loss and health-related quality of life in adolescence.
Childhood, 8 (6), [484].
(doi:10.3390/children8060484).
Abstract
Little is known about the impact of bilateral permanent childhood hearing loss (PCHL) on health-related quality of life (HRQoL). The objective of this study was to describe preference-based and non-preference based HRQoL outcomes in adolescence, from both self and proxy perspectives, amongst participants of the Hearing Outcomes Project. The Health Utilities Index Marks II (HUI2) and III (HUI3) and the PedsQL™ Version 4.0 Generic Core Scales were used to measure HRQoL based on self and parent proxy reports in 114 adolescents aged 13–19 years, 76 with bilateral PCHL and 38 with normal hearing, recruited from a population sample that was followed up from birth to adolescence. Descriptive statistics and multivariable analyses were used to estimate the relationship between severity of PCHL and HRQoL outcomes. PCHL was associated with decrements in mean multi-attribute utility score that varied between 0.078 and 0.148 for the HUI2 (p = 0.001) and between 0.205 and 0.315 for the HUI3 (p < 0.001), dependent upon the national tariff set applied and respondent group. Multivariable analyses revealed that, after controlling for clinical and sociodemographic covariates, mean HUI3 multi-attribute utility scores were significantly lower in adolescents with moderately severe, severe and profound hearing loss than in adolescents with normal hearing. Significant differences in physical functioning, social functioning, psychosocial functioning and total PedsQL™ scores were only observed when assessments by parents were relied upon, but these dissipated in the multivariable analyses. Bilateral PCHL is associated with poorer HRQoL outcomes in adolescence. Further studies conducted are needed to understand the trajectory and underpinning mechanisms of HRQoL outcomes following PCHL.
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children-08-00484
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More information
Accepted/In Press date: 3 June 2021
e-pub ahead of print date: 7 June 2021
Published date: 7 June 2021
Additional Information:
Funding Information:
This work was supported by The Wellcome Trust (Grant Number 089251/Z/09/Z). Petrou receives support as a NIHR Senior Investigator (NF-SI-0616-10103) and the NIHR Applied Research Collaboration Oxford and Thames Valley at Oxford Health NHS Foundation Trust. The other authors received no additional funding. The Wellcome Trust and the NIHR had no role in the design and conduct of the study.
Funding Information:
Funding: This work was supported by The Wellcome Trust (Grant Number 089251/Z/09/Z). Petrou receives support as a NIHR Senior Investigator (NF-SI-0616-10103) and the NIHR Applied Research Collaboration Oxford and Thames Valley at Oxford Health NHS Foundation Trust. The other authors received no additional funding. The Wellcome Trust and the NIHR had no role in the design and conduct of the study.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords:
Adolescence, Health utilities index, Health-related quality of life, Permanent childhood hearing loss, Preferences
Identifiers
Local EPrints ID: 449823
URI: http://eprints.soton.ac.uk/id/eprint/449823
ISSN: 0907-5682
PURE UUID: aa93ff80-d4be-4907-b05c-4b359d79f2d8
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Date deposited: 18 Jun 2021 16:31
Last modified: 16 Mar 2024 12:37
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Author:
Stavros Petrou
Author:
Kamran Khan
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