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Health-related quality of life issues, including symptoms, in patients with active COVID-19 or post COVID-19; a systematic literature review

Health-related quality of life issues, including symptoms, in patients with active COVID-19 or post COVID-19; a systematic literature review
Health-related quality of life issues, including symptoms, in patients with active COVID-19 or post COVID-19; a systematic literature review
Purpose: this systematic review was performed to identify all relevant health-related quality of life (HRQoL) issues associated with COVID-19.

Methods: systematic literature search was undertaken in April 2020. In four teams of three reviewers each, all abstracts were independently reviewed for inclusion by two reviewers. Using a pre-defined checklist of 93 criteria for each publication, data extraction was performed independently by two reviewers and subsequently compared and discussed. If necessary, a third reviewer resolved any discrepancies. The search was updated in February 2021 to retrieve new publications on HRQoL issues including issues related to the long-term consequences of COVID-19.

Results: the search in April 2020 identified 3342 potentially relevant publications, and 339 publications were selected for full-text review and data extraction. We identified 75 distinct symptoms and other HRQoL issues categorized into 12 thematic areas; from general symptoms such as fever, myalgia, and fatigue, to neurological and psychological issues. The updated search revealed three extra issues experienced during active disease and long-term problems with fatigue, psychological issues and impaired cognitive function.

Conclusion: this first comprehensive systematic review provides a detailed overview of the wide range of HRQoL issues experienced by patients with COVID-19 throughout the course of the disease. It demonstrates the devastating impact of the disease and provides critically important information for clinicians, to enable them to better recognize the disease and to provide knowledge important for treatment and follow-up. The results provided the foundation for the international development of a COVID-19 specific patient-reported HRQoL questionnaire.
COVID-19, Concerns, Health-related quality of life, Patient-reported outcome, Symptoms
0962-9343
Andal, Cecile D
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Pe, Madeline
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Falk, Ragnhild Sorum
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Piccinin, Claire
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Bottomley, Andrew
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Arraras, Juan Ignacio
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Darlington, Anne-Sophie
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Hofsa, Kristin
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Holzner, Bernard
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Jorgensen, Nina Marie Hoyning
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Kulis, Dagmara
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Rimehaug, Stein Arne
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Singer, Susanne
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Wheelwright, Sally
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Bjordal, Kristin
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Andal, Cecile D
00b40e13-aa76-43a0-8e81-4bfbb58adf52
Pe, Madeline
a17e12c4-e305-4411-99c6-2f91f43143be
Falk, Ragnhild Sorum
1b8b4edd-221d-4f5b-b241-32d92b949f34
Piccinin, Claire
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Bottomley, Andrew
0143e689-1361-437b-840d-ff6a651b53df
Arraras, Juan Ignacio
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Darlington, Anne-Sophie
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Hofsa, Kristin
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Holzner, Bernard
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Jorgensen, Nina Marie Hoyning
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Kulis, Dagmara
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Rimehaug, Stein Arne
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Singer, Susanne
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Wheelwright, Sally
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Bjordal, Kristin
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Andal, Cecile D, Pe, Madeline, Falk, Ragnhild Sorum, Piccinin, Claire, Bottomley, Andrew, Arraras, Juan Ignacio, Darlington, Anne-Sophie, Hofsa, Kristin, Holzner, Bernard, Jorgensen, Nina Marie Hoyning, Kulis, Dagmara, Rimehaug, Stein Arne, Singer, Susanne, Wheelwright, Sally and Bjordal, Kristin (2021) Health-related quality of life issues, including symptoms, in patients with active COVID-19 or post COVID-19; a systematic literature review. Quality of Life Research. (doi:10.1007/s11136-021-02908-z).

Record type: Article

Abstract

Purpose: this systematic review was performed to identify all relevant health-related quality of life (HRQoL) issues associated with COVID-19.

Methods: systematic literature search was undertaken in April 2020. In four teams of three reviewers each, all abstracts were independently reviewed for inclusion by two reviewers. Using a pre-defined checklist of 93 criteria for each publication, data extraction was performed independently by two reviewers and subsequently compared and discussed. If necessary, a third reviewer resolved any discrepancies. The search was updated in February 2021 to retrieve new publications on HRQoL issues including issues related to the long-term consequences of COVID-19.

Results: the search in April 2020 identified 3342 potentially relevant publications, and 339 publications were selected for full-text review and data extraction. We identified 75 distinct symptoms and other HRQoL issues categorized into 12 thematic areas; from general symptoms such as fever, myalgia, and fatigue, to neurological and psychological issues. The updated search revealed three extra issues experienced during active disease and long-term problems with fatigue, psychological issues and impaired cognitive function.

Conclusion: this first comprehensive systematic review provides a detailed overview of the wide range of HRQoL issues experienced by patients with COVID-19 throughout the course of the disease. It demonstrates the devastating impact of the disease and provides critically important information for clinicians, to enable them to better recognize the disease and to provide knowledge important for treatment and follow-up. The results provided the foundation for the international development of a COVID-19 specific patient-reported HRQoL questionnaire.

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More information

Accepted/In Press date: 7 June 2021
e-pub ahead of print date: 19 June 2021
Keywords: COVID-19, Concerns, Health-related quality of life, Patient-reported outcome, Symptoms

Identifiers

Local EPrints ID: 449900
URI: http://eprints.soton.ac.uk/id/eprint/449900
ISSN: 0962-9343
PURE UUID: 864bbb18-f872-48c3-a6e9-75befa0a4e10
ORCID for Sally Wheelwright: ORCID iD orcid.org/0000-0003-0657-2483

Catalogue record

Date deposited: 24 Jun 2021 16:31
Last modified: 02 Jul 2021 01:44

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Contributors

Author: Cecile D Andal
Author: Madeline Pe
Author: Ragnhild Sorum Falk
Author: Claire Piccinin
Author: Andrew Bottomley
Author: Juan Ignacio Arraras
Author: Kristin Hofsa
Author: Bernard Holzner
Author: Nina Marie Hoyning Jorgensen
Author: Dagmara Kulis
Author: Stein Arne Rimehaug
Author: Susanne Singer
Author: Kristin Bjordal

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