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FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan

FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan
FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan
Summary: age-specific intervention and assessment thresholds based on FRAX® were developed for eight Eurasian countries participating in the EVA study (Armenia, Belarus, Georgia, Moldova, Kazakhstan, the Kyrgyz Republic, the Russian Federation, and Uzbekistan). The intervention thresholds (major osteoporotic fracture) ranged from 3.6 (Armenia and Georgia) to 12.3% (Uzbekistan) for people at age 50 years, and from 16 (Armenia) to 27% (Belarus) at the age of 90 years. These thresholds enable a substantial advance in the ease of detection of individuals at high fracture risk.

Introduction: the purpose of this study was to derive and compare FRAX-based intervention and BMD assessment thresholds for 8 Eurasian countries in the EVA study.

Methods: the intervention threshold (IT) was set at a 10-year probability of a major osteoporotic fracture (MOF), calculated without BMD, equivalent to a woman with a prior fragility fracture but no other clinical risk factors, and a body mass index (BMI) of 25.0 kg/m2. The lower assessment threshold was set at a 10-year probability of a MOF in women with BMI of 25.0 kg/m2, without previous fracture or other clinical risk factors. The upper assessment threshold was set at 1.2 times the IT.

Results: the age-specific intervention thresholds ranged from 3.6 (Armenia and Georgia) to 12.3% (Uzbekistan) for men and women at the age of 50 years and from 16 (Armenia) to 27% (Belarus) at the age of 90 years. The difference between countries was most evident at younger ages and become progressively less with advancing age.

Conclusions: for the 8 Eurasian countries, the newly established FRAX-based intervention thresholds provide an opportunity to improve the clinical detection of both men and women with a high risk of fracture and improve treatment rates.
Assessment threshold, Epidemiology, FRAX, Fracture probability, Intervention threshold, Major osteoporotic fracture, Osteoporosis
1862-3522
Lesnyak, O.
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Zakroyeva, Alla
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Babalyan, Varta
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Cazac, Victor
fd78c9b4-54de-47a6-84df-a0948dcad57b
Gabdulina, Gulzhan
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Ismailov, Said
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Lobanchenko, Olga
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Rudenka, Ema
b855f3ca-1bfd-4d70-8045-caf69b810a23
Rudenka, Ema
f92492be-3ab4-4657-bf6b-63b02e3a781a
Tsagareli, Marina
3e3f75bf-fc6c-4859-9bb5-bdfaf1b0f5cc
Johansson, Helena
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Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
McCloskey, Eugene
3a2fac33-b400-4ae3-a212-04c3c3d2a517
Kanis, John A.
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Lesnyak, O.
79b8479e-2590-4bc1-8fbe-1f5941edc13e
Zakroyeva, Alla
cd5a3017-965e-4182-89bd-2ff944350a3e
Babalyan, Varta
55837b41-854a-4bf5-afce-a6779f12cc58
Cazac, Victor
fd78c9b4-54de-47a6-84df-a0948dcad57b
Gabdulina, Gulzhan
96e4b506-3ba4-429e-be78-47994ff66785
Ismailov, Said
7ccae754-35d1-4d1b-8f3f-ae2a882ed253
Lobanchenko, Olga
a3eb6662-17ba-4c79-8629-df6f1bb6cee4
Rudenka, Ema
b855f3ca-1bfd-4d70-8045-caf69b810a23
Rudenka, Ema
f92492be-3ab4-4657-bf6b-63b02e3a781a
Tsagareli, Marina
3e3f75bf-fc6c-4859-9bb5-bdfaf1b0f5cc
Johansson, Helena
04f12338-4dd1-437b-b9bc-e0884130c215
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
McCloskey, Eugene
3a2fac33-b400-4ae3-a212-04c3c3d2a517
Kanis, John A.
f1621d8d-8afb-4d97-9679-2165d88a344d

Lesnyak, O., Zakroyeva, Alla, Babalyan, Varta, Cazac, Victor, Gabdulina, Gulzhan, Ismailov, Said, Lobanchenko, Olga, Rudenka, Ema, Rudenka, Ema, Tsagareli, Marina, Johansson, Helena, Harvey, Nicholas, McCloskey, Eugene and Kanis, John A. (2021) FRAX-based intervention thresholds in eight Eurasian countries: Armenia, Belarus, Georgia, Kazakhstan, the Kyrgyz Republic, Moldova, the Russian Federation, and Uzbekistan. Archives of Osteoporosis, 16 (1), [87]. (doi:10.1007/s11657-021-00962-1).

Record type: Article

Abstract

Summary: age-specific intervention and assessment thresholds based on FRAX® were developed for eight Eurasian countries participating in the EVA study (Armenia, Belarus, Georgia, Moldova, Kazakhstan, the Kyrgyz Republic, the Russian Federation, and Uzbekistan). The intervention thresholds (major osteoporotic fracture) ranged from 3.6 (Armenia and Georgia) to 12.3% (Uzbekistan) for people at age 50 years, and from 16 (Armenia) to 27% (Belarus) at the age of 90 years. These thresholds enable a substantial advance in the ease of detection of individuals at high fracture risk.

Introduction: the purpose of this study was to derive and compare FRAX-based intervention and BMD assessment thresholds for 8 Eurasian countries in the EVA study.

Methods: the intervention threshold (IT) was set at a 10-year probability of a major osteoporotic fracture (MOF), calculated without BMD, equivalent to a woman with a prior fragility fracture but no other clinical risk factors, and a body mass index (BMI) of 25.0 kg/m2. The lower assessment threshold was set at a 10-year probability of a MOF in women with BMI of 25.0 kg/m2, without previous fracture or other clinical risk factors. The upper assessment threshold was set at 1.2 times the IT.

Results: the age-specific intervention thresholds ranged from 3.6 (Armenia and Georgia) to 12.3% (Uzbekistan) for men and women at the age of 50 years and from 16 (Armenia) to 27% (Belarus) at the age of 90 years. The difference between countries was most evident at younger ages and become progressively less with advancing age.

Conclusions: for the 8 Eurasian countries, the newly established FRAX-based intervention thresholds provide an opportunity to improve the clinical detection of both men and women with a high risk of fracture and improve treatment rates.

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More information

Accepted/In Press date: 25 April 2021
e-pub ahead of print date: 5 June 2021
Keywords: Assessment threshold, Epidemiology, FRAX, Fracture probability, Intervention threshold, Major osteoporotic fracture, Osteoporosis

Identifiers

Local EPrints ID: 450030
URI: http://eprints.soton.ac.uk/id/eprint/450030
ISSN: 1862-3522
PURE UUID: 95773ec6-d143-4394-a7c5-46595ccb735b
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 06 Jul 2021 16:31
Last modified: 26 Nov 2021 02:48

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Contributors

Author: O. Lesnyak
Author: Alla Zakroyeva
Author: Varta Babalyan
Author: Victor Cazac
Author: Gulzhan Gabdulina
Author: Said Ismailov
Author: Olga Lobanchenko
Author: Ema Rudenka
Author: Ema Rudenka
Author: Marina Tsagareli
Author: Helena Johansson
Author: Nicholas Harvey ORCID iD
Author: Eugene McCloskey
Author: John A. Kanis

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