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An evaluation of the mental health impact of SARS-CoV-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis

An evaluation of the mental health impact of SARS-CoV-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis
An evaluation of the mental health impact of SARS-CoV-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis

Background: The global impact of COVID-19 pandemic continues to affect the lives of billions of people with recurrent waves. Healthcare systems are struggling to manage pre-existing patient care and recurring covid-19 demands. As a result, we evaluated the mental health impact using systematic review and meta-analysis. Methods: A comprehensive search was undertaken from April 2020 to 22nd January 2021 using multiple electronic databases. A systematic review protocol was developed and published on PROSPERO registration; CRD42020181481. A random-effects model was used to compute pooled estimates of anxiety, depression, PTSD, insomnia and suicidal thoughts. Findings: Our search yielded 11,295 studies and of those 287 met the inclusion criteria. The meta-analysis of 206 studies revealed minimal differences in prevalence of anxiety, depression, and PTSD among HCPs compared with the public during the pandemic but higher prevalence of suicidal thoughts/ideation or self-harm (11% vs 5.8%) and lower prevalence of wellbeing (28.2% vs 52.6%) among the public compared to HCPs. Interpretation: The pandemic has led to a high mental health burden especially amongst HCPs and higher suicidal ideation and lower wellbeing in general public which warrants further investigation and management globally. These findings highlight an emerging critical public health issue that requires urgent solutions.

COVID-19, Health, Healthcare professionals, Mental health and physical wellbeing, Sars-CoV-2
2589-5370
Phiri, Peter
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Ramakrishnan, Rema
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Rathod, Shanaya
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Elliot, Kathryn
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Thayanandan, Tony
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Sandle, Natasha
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Haque, Nyla
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Chau, Steven W.h.
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Wong, Oscar W.h.
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Chan, Sandra S.m.
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Wong, Evelyn K.y.
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Raymont, Vanessa
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Au-yeung, Sheena K.
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Kingdon, David
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Delanerolle, Gayathri
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Phiri, Peter
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Ramakrishnan, Rema
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Rathod, Shanaya
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Elliot, Kathryn
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Thayanandan, Tony
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Sandle, Natasha
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Haque, Nyla
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Chau, Steven W.h.
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Wong, Oscar W.h.
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Chan, Sandra S.m.
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Wong, Evelyn K.y.
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Raymont, Vanessa
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Au-yeung, Sheena K.
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Kingdon, David
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Delanerolle, Gayathri
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Phiri, Peter, Ramakrishnan, Rema, Rathod, Shanaya, Elliot, Kathryn, Thayanandan, Tony, Sandle, Natasha, Haque, Nyla, Chau, Steven W.h., Wong, Oscar W.h., Chan, Sandra S.m., Wong, Evelyn K.y., Raymont, Vanessa, Au-yeung, Sheena K., Kingdon, David and Delanerolle, Gayathri (2021) An evaluation of the mental health impact of SARS-CoV-2 on patients, general public and healthcare professionals: A systematic review and meta-analysis. EClinicalMedicine, 34, [100806]. (doi:10.1016/j.eclinm.2021.100806).

Record type: Article

Abstract

Background: The global impact of COVID-19 pandemic continues to affect the lives of billions of people with recurrent waves. Healthcare systems are struggling to manage pre-existing patient care and recurring covid-19 demands. As a result, we evaluated the mental health impact using systematic review and meta-analysis. Methods: A comprehensive search was undertaken from April 2020 to 22nd January 2021 using multiple electronic databases. A systematic review protocol was developed and published on PROSPERO registration; CRD42020181481. A random-effects model was used to compute pooled estimates of anxiety, depression, PTSD, insomnia and suicidal thoughts. Findings: Our search yielded 11,295 studies and of those 287 met the inclusion criteria. The meta-analysis of 206 studies revealed minimal differences in prevalence of anxiety, depression, and PTSD among HCPs compared with the public during the pandemic but higher prevalence of suicidal thoughts/ideation or self-harm (11% vs 5.8%) and lower prevalence of wellbeing (28.2% vs 52.6%) among the public compared to HCPs. Interpretation: The pandemic has led to a high mental health burden especially amongst HCPs and higher suicidal ideation and lower wellbeing in general public which warrants further investigation and management globally. These findings highlight an emerging critical public health issue that requires urgent solutions.

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More information

Accepted/In Press date: 5 March 2021
e-pub ahead of print date: 6 April 2021
Published date: April 2021
Keywords: COVID-19, Health, Healthcare professionals, Mental health and physical wellbeing, Sars-CoV-2

Identifiers

Local EPrints ID: 450101
URI: http://eprints.soton.ac.uk/id/eprint/450101
ISSN: 2589-5370
PURE UUID: b6afa091-5a09-45de-a2c3-6f334664096b

Catalogue record

Date deposited: 09 Jul 2021 16:34
Last modified: 09 Jan 2022 04:14

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Contributors

Author: Peter Phiri
Author: Rema Ramakrishnan
Author: Shanaya Rathod
Author: Kathryn Elliot
Author: Tony Thayanandan
Author: Natasha Sandle
Author: Nyla Haque
Author: Steven W.h. Chau
Author: Oscar W.h. Wong
Author: Sandra S.m. Chan
Author: Evelyn K.y. Wong
Author: Vanessa Raymont
Author: Sheena K. Au-yeung
Author: David Kingdon
Author: Gayathri Delanerolle

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