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Metabolic phenotyping of opioid and psychostimulant addiction: a novel approach for biomarker discovery and biochemical understanding of the disorder

Metabolic phenotyping of opioid and psychostimulant addiction: a novel approach for biomarker discovery and biochemical understanding of the disorder
Metabolic phenotyping of opioid and psychostimulant addiction: a novel approach for biomarker discovery and biochemical understanding of the disorder

Despite the progress in characterising the pharmacological profile of drugs of abuse, their precise biochemical impact remains unclear. The metabolome reflects the multifaceted biochemical processes occurring within a biological system. This includes those encoded in the genome but also those arising from environmental/exogenous exposures and interactions between the two. Using metabolomics, the biochemical derangements associated with substance abuse can be determined as the individual transitions from recreational drug to chronic use (dependence). By understanding the biomolecular perturbations along this time course and how they vary across individuals, metabolomics can elucidate biochemical mechanisms of the addiction cycle (dependence/withdrawal/relapse) and predict prognosis (recovery/relapse). In this review, we summarise human and animal metabolomic studies in the field of opioid and psychostimulant addiction. We highlight the importance of metabolomics as a powerful approach for biomarker discovery and its potential to guide personalised pharmacotherapeutic strategies for addiction targeted towards the individual's metabolome.

addiction, cocaine, heroin, metabolism, metabolomics, methamphetamine, morphine
0007-1188
Caspani, Giorgia
ca711d7a-4d4b-4b99-8550-db8ed3ad612e
Sebők, Viktoria
34dfb48b-a920-4d1e-9aa0-45072482088f
Sultana, Nowshin
f7fd1786-3158-45d8-ad58-bbfb8681964b
Swann, Jonathan R
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Bailey, Alexis
d09ba6bc-ba4e-46ac-bd3b-26589d33e7bd
Caspani, Giorgia
ca711d7a-4d4b-4b99-8550-db8ed3ad612e
Sebők, Viktoria
34dfb48b-a920-4d1e-9aa0-45072482088f
Sultana, Nowshin
f7fd1786-3158-45d8-ad58-bbfb8681964b
Swann, Jonathan R
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Bailey, Alexis
d09ba6bc-ba4e-46ac-bd3b-26589d33e7bd

Caspani, Giorgia, Sebők, Viktoria, Sultana, Nowshin, Swann, Jonathan R and Bailey, Alexis (2021) Metabolic phenotyping of opioid and psychostimulant addiction: a novel approach for biomarker discovery and biochemical understanding of the disorder. British Journal of Pharmacology. (doi:10.1111/bph.15475).

Record type: Review

Abstract

Despite the progress in characterising the pharmacological profile of drugs of abuse, their precise biochemical impact remains unclear. The metabolome reflects the multifaceted biochemical processes occurring within a biological system. This includes those encoded in the genome but also those arising from environmental/exogenous exposures and interactions between the two. Using metabolomics, the biochemical derangements associated with substance abuse can be determined as the individual transitions from recreational drug to chronic use (dependence). By understanding the biomolecular perturbations along this time course and how they vary across individuals, metabolomics can elucidate biochemical mechanisms of the addiction cycle (dependence/withdrawal/relapse) and predict prognosis (recovery/relapse). In this review, we summarise human and animal metabolomic studies in the field of opioid and psychostimulant addiction. We highlight the importance of metabolomics as a powerful approach for biomarker discovery and its potential to guide personalised pharmacotherapeutic strategies for addiction targeted towards the individual's metabolome.

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More information

Accepted/In Press date: 26 March 2021
e-pub ahead of print date: 4 April 2021
Keywords: addiction, cocaine, heroin, metabolism, metabolomics, methamphetamine, morphine

Identifiers

Local EPrints ID: 450103
URI: http://eprints.soton.ac.uk/id/eprint/450103
ISSN: 0007-1188
PURE UUID: 3d518dab-1029-4d03-8caf-12598fb21dc1
ORCID for Jonathan R Swann: ORCID iD orcid.org/0000-0002-6485-4529

Catalogue record

Date deposited: 09 Jul 2021 16:34
Last modified: 26 Nov 2021 03:21

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Contributors

Author: Giorgia Caspani
Author: Viktoria Sebők
Author: Nowshin Sultana
Author: Alexis Bailey

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