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Serotype distribution of invasive, non-invasive and carried Streptococcus pneumoniae in Malaysia: a meta-analysis

Serotype distribution of invasive, non-invasive and carried Streptococcus pneumoniae in Malaysia: a meta-analysis
Serotype distribution of invasive, non-invasive and carried Streptococcus pneumoniae in Malaysia: a meta-analysis

Background: pneumococcal pneumonia is the leading cause of under-five mortality globally. The surveillance of pneumococcal serotypes is therefore vital for informing pneumococcal vaccination policy and programmes. Pneumococcal conjugate vaccines (PCVs) have been available as an option in the private healthcare setting and beginning December 2020, PCV10 was incorporated as part of routine national immunisation programme (NIP) in Malaysia. We searched existing literature on pneumococcal serotype distribution across Malaysia to provide an overall view of this distribution before the implementation of PCV10.

Methods: online databases (PubMed, Ovid MEDLINE and Scopus), reference lists of articles identified, and grey literature (Malaysian Ministry of Health website, WHO website) were systematically searched for relevant literature on pneumococcal serotype distribution across Malaysia up to 10th November 2020. No lower date limit was set to maximise the number of target reports returned. Results of serotypes were split by age categories, including ≤5 years, > 5 years and unreported for those that did not specify.

Results: the search returned 18 relevant results, with a total of 2040 isolates. The most common serotypes across all disease types were 19F (n = 313, 15.3% [95%CI: 13.8-17.0]), 23F (n = 166, 8.1% [95%CI: 7.0-9.4]), 14 (n = 166, 8.1% [95%CI: 7.0-9.4]), 6B (n = 163, 8.0% [95%CI: 6.9-9.2]) and 19A (n = 138, 6.8% [95%CI: 5.8-7.9]).

Conclusion: four of the most common serotypes across all isolate sources in Malaysia are covered by PCV10, while PCV13 provides greater serotype coverage in comparison to PCV10. There is still a need for surveillance studies, particularly those investigating serotypes in children under 5 years of age, to monitor vaccine effectiveness and pneumococcal population dynamic following implementation of PCV10 into routine immunisation.

Antimicrobial resistance, National Immunisation Programme, PCV10, PCV13, Pneumococcal disease, Pneumonia, Serotype, Vaccine, Vaccine types
2200-6133
Lister, Alex J J
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Le, Cheng Foh
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Cheah, Eddy Seong Guan
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Desa, Mohd Nasir Mohd
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Cleary, David W
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Clarke, Stuart C
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Lister, Alex J J
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Le, Cheng Foh
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Cheah, Eddy Seong Guan
b409b18b-d6b8-424e-be35-7ffb35a7f857
Desa, Mohd Nasir Mohd
f48895b1-0676-4a02-a6b1-ded277a045b6
Cleary, David W
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Clarke, Stuart C
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Lister, Alex J J, Le, Cheng Foh, Cheah, Eddy Seong Guan, Desa, Mohd Nasir Mohd, Cleary, David W and Clarke, Stuart C (2021) Serotype distribution of invasive, non-invasive and carried Streptococcus pneumoniae in Malaysia: a meta-analysis. Pneumonia, 13 (1), [9]. (doi:10.1186/s41479-021-00086-7).

Record type: Article

Abstract

Background: pneumococcal pneumonia is the leading cause of under-five mortality globally. The surveillance of pneumococcal serotypes is therefore vital for informing pneumococcal vaccination policy and programmes. Pneumococcal conjugate vaccines (PCVs) have been available as an option in the private healthcare setting and beginning December 2020, PCV10 was incorporated as part of routine national immunisation programme (NIP) in Malaysia. We searched existing literature on pneumococcal serotype distribution across Malaysia to provide an overall view of this distribution before the implementation of PCV10.

Methods: online databases (PubMed, Ovid MEDLINE and Scopus), reference lists of articles identified, and grey literature (Malaysian Ministry of Health website, WHO website) were systematically searched for relevant literature on pneumococcal serotype distribution across Malaysia up to 10th November 2020. No lower date limit was set to maximise the number of target reports returned. Results of serotypes were split by age categories, including ≤5 years, > 5 years and unreported for those that did not specify.

Results: the search returned 18 relevant results, with a total of 2040 isolates. The most common serotypes across all disease types were 19F (n = 313, 15.3% [95%CI: 13.8-17.0]), 23F (n = 166, 8.1% [95%CI: 7.0-9.4]), 14 (n = 166, 8.1% [95%CI: 7.0-9.4]), 6B (n = 163, 8.0% [95%CI: 6.9-9.2]) and 19A (n = 138, 6.8% [95%CI: 5.8-7.9]).

Conclusion: four of the most common serotypes across all isolate sources in Malaysia are covered by PCV10, while PCV13 provides greater serotype coverage in comparison to PCV10. There is still a need for surveillance studies, particularly those investigating serotypes in children under 5 years of age, to monitor vaccine effectiveness and pneumococcal population dynamic following implementation of PCV10 into routine immunisation.

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e-pub ahead of print date: 25 May 2021
Published date: 25 May 2021
Keywords: Antimicrobial resistance, National Immunisation Programme, PCV10, PCV13, Pneumococcal disease, Pneumonia, Serotype, Vaccine, Vaccine types

Identifiers

Local EPrints ID: 450133
URI: http://eprints.soton.ac.uk/id/eprint/450133
ISSN: 2200-6133
PURE UUID: 3023e56c-0147-4a0e-a068-ecdf94d8ee57
ORCID for David W Cleary: ORCID iD orcid.org/0000-0003-4533-0700
ORCID for Stuart C Clarke: ORCID iD orcid.org/0000-0002-7009-1548

Catalogue record

Date deposited: 13 Jul 2021 16:30
Last modified: 12 Nov 2021 02:53

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Contributors

Author: Alex J J Lister
Author: Cheng Foh Le
Author: Eddy Seong Guan Cheah
Author: Mohd Nasir Mohd Desa
Author: David W Cleary ORCID iD
Author: Stuart C Clarke ORCID iD

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