Using a biomarker acutely to identify babies at risk of serious adverse effects from antibiotics: where is the 'Terrible Moral and Medical Dilemma'?
Using a biomarker acutely to identify babies at risk of serious adverse effects from antibiotics: where is the 'Terrible Moral and Medical Dilemma'?
We thank Parker and Wright for engaging in this roundtable debate in such a spirited way. The 'Pharmacogenetic [test] to Avoid Loss of Hearing' (PALOH) Trial is the first time a genetic point of care test has been applied in the acute neonatal setting; therefore, it is not surprising that questions have been raised which require debate, discussion and clarification. Parker and Wright misattribute several assumptions to the roundtable authors, which we would like to clarify here. Since they raise wider questions about the PALOH trial itself, several of the roundtable discussants have made a joint response.
Anti-Bacterial Agents/adverse effects, Biomarkers, Genetic Testing, Humans, Infant, Infant, Newborn, Morals
117-118
Lucassen, Anneke M
2eb85efc-c6e8-4c3f-b963-0290f6c038a5
McDermott, John Henry
5e443a39-3aa3-424e-ba8c-efdf2df49f12
Newman, William
33e93bfe-d7b5-4bec-942d-92f4c6276f62
1 February 2021
Lucassen, Anneke M
2eb85efc-c6e8-4c3f-b963-0290f6c038a5
McDermott, John Henry
5e443a39-3aa3-424e-ba8c-efdf2df49f12
Newman, William
33e93bfe-d7b5-4bec-942d-92f4c6276f62
Lucassen, Anneke M, McDermott, John Henry and Newman, William
(2021)
Using a biomarker acutely to identify babies at risk of serious adverse effects from antibiotics: where is the 'Terrible Moral and Medical Dilemma'?
Journal of Medical Ethics, 47 (2), .
(doi:10.1136/medethics-2020-107048).
Abstract
We thank Parker and Wright for engaging in this roundtable debate in such a spirited way. The 'Pharmacogenetic [test] to Avoid Loss of Hearing' (PALOH) Trial is the first time a genetic point of care test has been applied in the acute neonatal setting; therefore, it is not surprising that questions have been raised which require debate, discussion and clarification. Parker and Wright misattribute several assumptions to the roundtable authors, which we would like to clarify here. Since they raise wider questions about the PALOH trial itself, several of the roundtable discussants have made a joint response.
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Published date: 1 February 2021
Additional Information:
Funding Information:
Funding WN is supported by the Manchester NIHR BRC (IS-BRC-1215-20007) AML’s work is supported by funding from a Wellcome Trust collaborative award 208053/Z/17/Z.
Publisher Copyright:
© 2021 BMJ Publishing Group. All rights reserved.
Keywords:
Anti-Bacterial Agents/adverse effects, Biomarkers, Genetic Testing, Humans, Infant, Infant, Newborn, Morals
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Local EPrints ID: 450175
URI: http://eprints.soton.ac.uk/id/eprint/450175
ISSN: 1473-4257
PURE UUID: 7db59f79-3bbc-4730-b10e-5c2ee69c2dbb
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Date deposited: 14 Jul 2021 16:49
Last modified: 17 Mar 2024 02:54
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Author:
John Henry McDermott
Author:
William Newman
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