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Blunted sweating does not alter the rise in core temperature in people with multiple sclerosis exercising in the heat

Blunted sweating does not alter the rise in core temperature in people with multiple sclerosis exercising in the heat
Blunted sweating does not alter the rise in core temperature in people with multiple sclerosis exercising in the heat

The purpose of this study is to determine whether thermoregulatory capacity is altered by multiple sclerosis (MS) during exercise in the heat. Sixteen MS participants (EDSS: 2.9 ± 0.9; 47 ± 8 yr; 77.6 ± 14.0 kg) and 14 healthy control (CON) participants (43 ± 11 yr; 78.6 ± 17.0 kg) cycled at a heat production of 4 W·kg-1 for 60 min at 30°C, 30% relative humidity (RH) (Warm). A subset of eight MS (EDSS: 2.6 ± 0.5; 44 ± 8 yr; 82.3 ± 18.2 kg) and 8 CON (44 ± 12 yr; 81.2 ± 21.1 kg) also exercised at 35°C, 30% RH (Hot). Rectal temperature (Tre), mean skin (Tsk) temperature, and local sweat rate (LSR) on the upper back (LSRback) and forearm (LSRarm) were measured. All CON, and only 9 of 16 and 7 of 8 MS participants completed 60 min of exercise in Warm and Hot trials, respectively. All MS participants who were unable to complete exercise stopped with a ΔTre between 0.2 and 0.5°C. The time to reach a ΔTre of 0.2°C was similar (MS: 28 ± 15 min, CON: 32 ± 18 min; P = 0.51). For MS participants, completing 60-min of exercise in Warm, ΔTre (P = 0.13), ΔTsk (P = 0.45), LSRback (P = 0.69), and LSRarm (P = 0.54) was similar to CON, but ΔTb (body temperature) (MS: 0.16 ± 0.13°C, CON: 0.07 ± 0.06°C; P = 0.02) and onset time (MS: 16 ± 10 min, CON: 8 ± 5 min; P = 0.02) for sweating were greater in MS. Similarly, in Hot, ΔTre (P = 0.52), ΔTsk (P = 0.06), LSRback (P = 0.59), and LSRarm (P = 0.08) were similar, but ΔTb (MS: 0.19 ± 0.16°C, CON: 0.06 ± 0.04°C; P = 0.04) and onset time (MS: 13 ± 7 min, CON: 6 ± 3 min; P = 0.02) for sweating were greater in MS. Even at 35°C, a delayed sweating onset did not alter heat loss to sufficiently affect exercise-induced rises in core temperature. Heat intolerance with MS does not seem attributable to thermoregulatory impairments.

Autonomic dysfunction, Heat sensitivity, Thermoregulation, Uhthoff's phenomenon
258-267
Chaseling, Georgia K.
34771262-b371-4d37-b631-e60d5e65d752
Filingeri, Davide
42502a34-e7e6-4b49-b304-ce2ae0bf7b24
Allen, Dustin
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Barnett, Michael
c85ddfdb-34b3-456c-af33-e0d158583479
Vucic, Steve
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Davis, Scott L.
8cacbc30-25be-492f-bf2c-8577f0bb3978
Jay, Ollie
2e255cfd-1fc6-4ce7-891d-4fcba88c0250
Chaseling, Georgia K.
34771262-b371-4d37-b631-e60d5e65d752
Filingeri, Davide
42502a34-e7e6-4b49-b304-ce2ae0bf7b24
Allen, Dustin
0f989f80-a1a9-42e4-828c-4f41b564c6b1
Barnett, Michael
c85ddfdb-34b3-456c-af33-e0d158583479
Vucic, Steve
916aa133-994f-4c38-8941-0e7756645a5a
Davis, Scott L.
8cacbc30-25be-492f-bf2c-8577f0bb3978
Jay, Ollie
2e255cfd-1fc6-4ce7-891d-4fcba88c0250

Chaseling, Georgia K., Filingeri, Davide, Allen, Dustin, Barnett, Michael, Vucic, Steve, Davis, Scott L. and Jay, Ollie (2021) Blunted sweating does not alter the rise in core temperature in people with multiple sclerosis exercising in the heat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 320 (3), 258-267. (doi:10.1152/ajpregu.00090.2020).

Record type: Article

Abstract

The purpose of this study is to determine whether thermoregulatory capacity is altered by multiple sclerosis (MS) during exercise in the heat. Sixteen MS participants (EDSS: 2.9 ± 0.9; 47 ± 8 yr; 77.6 ± 14.0 kg) and 14 healthy control (CON) participants (43 ± 11 yr; 78.6 ± 17.0 kg) cycled at a heat production of 4 W·kg-1 for 60 min at 30°C, 30% relative humidity (RH) (Warm). A subset of eight MS (EDSS: 2.6 ± 0.5; 44 ± 8 yr; 82.3 ± 18.2 kg) and 8 CON (44 ± 12 yr; 81.2 ± 21.1 kg) also exercised at 35°C, 30% RH (Hot). Rectal temperature (Tre), mean skin (Tsk) temperature, and local sweat rate (LSR) on the upper back (LSRback) and forearm (LSRarm) were measured. All CON, and only 9 of 16 and 7 of 8 MS participants completed 60 min of exercise in Warm and Hot trials, respectively. All MS participants who were unable to complete exercise stopped with a ΔTre between 0.2 and 0.5°C. The time to reach a ΔTre of 0.2°C was similar (MS: 28 ± 15 min, CON: 32 ± 18 min; P = 0.51). For MS participants, completing 60-min of exercise in Warm, ΔTre (P = 0.13), ΔTsk (P = 0.45), LSRback (P = 0.69), and LSRarm (P = 0.54) was similar to CON, but ΔTb (body temperature) (MS: 0.16 ± 0.13°C, CON: 0.07 ± 0.06°C; P = 0.02) and onset time (MS: 16 ± 10 min, CON: 8 ± 5 min; P = 0.02) for sweating were greater in MS. Similarly, in Hot, ΔTre (P = 0.52), ΔTsk (P = 0.06), LSRback (P = 0.59), and LSRarm (P = 0.08) were similar, but ΔTb (MS: 0.19 ± 0.16°C, CON: 0.06 ± 0.04°C; P = 0.04) and onset time (MS: 13 ± 7 min, CON: 6 ± 3 min; P = 0.02) for sweating were greater in MS. Even at 35°C, a delayed sweating onset did not alter heat loss to sufficiently affect exercise-induced rises in core temperature. Heat intolerance with MS does not seem attributable to thermoregulatory impairments.

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ajpregu.00090.2020 (1) - Accepted Manuscript
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e-pub ahead of print date: 2 March 2021
Keywords: Autonomic dysfunction, Heat sensitivity, Thermoregulation, Uhthoff's phenomenon

Identifiers

Local EPrints ID: 450194
URI: http://eprints.soton.ac.uk/id/eprint/450194
PURE UUID: 68bd036f-07bb-4145-9695-b94ef24a30d6
ORCID for Davide Filingeri: ORCID iD orcid.org/0000-0001-5652-395X

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Date deposited: 15 Jul 2021 16:37
Last modified: 17 Mar 2024 06:34

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Contributors

Author: Georgia K. Chaseling
Author: Dustin Allen
Author: Michael Barnett
Author: Steve Vucic
Author: Scott L. Davis
Author: Ollie Jay

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