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Childhood vascular phenotypes have differing associations with prenatal and postnatal growth

Childhood vascular phenotypes have differing associations with prenatal and postnatal growth
Childhood vascular phenotypes have differing associations with prenatal and postnatal growth
Objective:
In children aged 8--9 years, we examined the associations of linear and abdominal circumference growth during critical stages of prenatal and postnatal development with six vascular measurements commonly used as early markers of atherosclerosis and later cardiovascular disease (CVD) risk.

Methods:
In 724 children from the UK Southampton Women's Survey mother--offspring cohort, offspring length/height and abdominal circumference measurements were collected at 10 ages between 11 weeks’ gestation and age 8--9 years. Using residual growth modelling and linear regression, we examined the independent associations between growth and detailed vascular measures made at 8--9 years.

Results:
Postnatal linear and abdominal circumference growth were associated with higher childhood SBP and carotid--femoral pulse wave velocity, whereas prenatal growth was not. For example, 1SD faster abdominal circumference gain between ages 3 and 6 years was associated with 2.27 [95% confidence interval (CI): 1.56--2.98] mmHg higher SBP. In contrast, faster abdominal circumference gain before 19 weeks’ gestation was associated with greater carotid intima--media thickness [0.009 mm (0.004--0.015) per 1SD larger 19-week abdominal circumference), whereas later growth was not. We found no strong associations between prenatal or postnatal growth and DBP or measures of endothelial function.

Conclusion:
Higher postnatal linear growth and adiposity gain are related to higher SBP and carotid--femoral pulse wave velocity in childhood. In contrast, faster growth in early gestation is associated with greater childhood carotid intima--media thickness, perhaps resulting from subtle changes in vascular structure that reflect physiological adaptations rather than subclinical atherosclerosis.
0263-6352
1884-1892
Sletner, Line
16435d99-972f-4b1e-8c5e-a10bbd79c322
Crozier, Sarah R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Mahon, Pamela
5a824126-9030-4e8a-9a0e-dafb8aa280f9
Chiesa, Scott T.
ec13f5db-9caa-4942-b951-a9f003a76253
Charakida, Marietta
0e6ebee0-5aec-44f1-a5e3-df4ceb761976
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Sletner, Line
16435d99-972f-4b1e-8c5e-a10bbd79c322
Crozier, Sarah R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Mahon, Pamela
5a824126-9030-4e8a-9a0e-dafb8aa280f9
Chiesa, Scott T.
ec13f5db-9caa-4942-b951-a9f003a76253
Charakida, Marietta
0e6ebee0-5aec-44f1-a5e3-df4ceb761976
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Hanson, Mark
1952fad1-abc7-4284-a0bc-a7eb31f70a3f

Sletner, Line, Crozier, Sarah R., Inskip, Hazel M., Godfrey, Keith M., Mahon, Pamela, Chiesa, Scott T., Charakida, Marietta, Cooper, Cyrus and Hanson, Mark (2021) Childhood vascular phenotypes have differing associations with prenatal and postnatal growth. Journal of Hypertension, Publish Ahead o (9), 1884-1892. (doi:10.1097/HJH.0000000000002870).

Record type: Article

Abstract

Objective:
In children aged 8--9 years, we examined the associations of linear and abdominal circumference growth during critical stages of prenatal and postnatal development with six vascular measurements commonly used as early markers of atherosclerosis and later cardiovascular disease (CVD) risk.

Methods:
In 724 children from the UK Southampton Women's Survey mother--offspring cohort, offspring length/height and abdominal circumference measurements were collected at 10 ages between 11 weeks’ gestation and age 8--9 years. Using residual growth modelling and linear regression, we examined the independent associations between growth and detailed vascular measures made at 8--9 years.

Results:
Postnatal linear and abdominal circumference growth were associated with higher childhood SBP and carotid--femoral pulse wave velocity, whereas prenatal growth was not. For example, 1SD faster abdominal circumference gain between ages 3 and 6 years was associated with 2.27 [95% confidence interval (CI): 1.56--2.98] mmHg higher SBP. In contrast, faster abdominal circumference gain before 19 weeks’ gestation was associated with greater carotid intima--media thickness [0.009 mm (0.004--0.015) per 1SD larger 19-week abdominal circumference), whereas later growth was not. We found no strong associations between prenatal or postnatal growth and DBP or measures of endothelial function.

Conclusion:
Higher postnatal linear growth and adiposity gain are related to higher SBP and carotid--femoral pulse wave velocity in childhood. In contrast, faster growth in early gestation is associated with greater childhood carotid intima--media thickness, perhaps resulting from subtle changes in vascular structure that reflect physiological adaptations rather than subclinical atherosclerosis.

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More information

Published date: 10 May 2021

Identifiers

Local EPrints ID: 450370
URI: http://eprints.soton.ac.uk/id/eprint/450370
ISSN: 0263-6352
PURE UUID: 60d1cf80-7379-4202-a465-f626afb5211a
ORCID for Sarah R. Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Hazel M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Mark Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 26 Jul 2021 16:31
Last modified: 12 Nov 2021 02:38

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Contributors

Author: Line Sletner
Author: Hazel M. Inskip ORCID iD
Author: Pamela Mahon
Author: Scott T. Chiesa
Author: Marietta Charakida
Author: Cyrus Cooper ORCID iD
Author: Mark Hanson ORCID iD

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