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The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables
The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables

The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network’s core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network’s data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community.

Birth cohort, Cross-cohort collaboration, Data harmonisation, FAIR (findable, accessible, interoperable and reusable) principles, Lifecourse epidemiology
0393-2990
565-580
Pinot de Moira, Angela
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Haakma, Sido
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Strandberg-Larsen, Katrine
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Kooijman, Marjolein
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Cadman, Tim
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Cardol, Marloes
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Corpeleijn, Eva
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Crozier, Sarah
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Duijts, Liesbeth
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Elhakeem, Ahmed
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Eriksson, Johan G.
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Felix, Janine F.
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Fernández-Barrés, Sílvia
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Foong, Rachel
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Forhan, Anne
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Grote, Veit
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Guerlich, Kathrin
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Heude, Barbara
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Huang, Rae-Chi
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Järvelin, Marjo-Riitta
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Jørgensen, Anne Cathrine
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Mikkola, Tuija M.
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Nader, Johanna L. T.
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Pedersen, Marie
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Popovic, Maja
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Rautio, Nina
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Richiardi, Lorenzo
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Roumeliotaki, Theano
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Ronkainen, Justiina
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Inskip, Hazel
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Pinot de Moira, Angela
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Haakma, Sido
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Strandberg-Larsen, Katrine
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Kooijman, Marjolein
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Cadman, Tim
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Cardol, Marloes
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Corpeleijn, Eva
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Crozier, Sarah
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Duijts, Liesbeth
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Elhakeem, Ahmed
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Eriksson, Johan G.
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Felix, Janine F.
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Fernández-Barrés, Sílvia
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Foong, Rachel
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Forhan, Anne
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Grote, Veit
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Guerlich, Kathrin
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Heude, Barbara
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Huang, Rae-Chi
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Järvelin, Marjo-Riitta
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Jørgensen, Anne Cathrine
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Mikkola, Tuija M.
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Nader, Johanna L. T.
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Pedersen, Marie
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Popovic, Maja
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Rautio, Nina
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Richiardi, Lorenzo
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Roumeliotaki, Theano
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Ronkainen, Justiina
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Inskip, Hazel
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Pinot de Moira, Angela, Haakma, Sido, Strandberg-Larsen, Katrine, Kooijman, Marjolein, Cadman, Tim, Cardol, Marloes, Corpeleijn, Eva, Crozier, Sarah, Duijts, Liesbeth, Elhakeem, Ahmed, Eriksson, Johan G., Felix, Janine F., Fernández-Barrés, Sílvia, Foong, Rachel, Forhan, Anne, Grote, Veit, Guerlich, Kathrin, Heude, Barbara, Huang, Rae-Chi, Järvelin, Marjo-Riitta, Jørgensen, Anne Cathrine, Mikkola, Tuija M., Nader, Johanna L. T., Pedersen, Marie, Popovic, Maja, Rautio, Nina, Richiardi, Lorenzo, Roumeliotaki, Theano, Ronkainen, Justiina and Inskip, Hazel (2021) The EU Child Cohort Network’s core data: establishing a set of findable, accessible, interoperable and re-usable (FAIR) variables. European Journal of Epidemiology, 36 (5), 565-580. (doi:10.1007/s10654-021-00733-9).

Record type: Article

Abstract

The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network’s core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network’s data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community.

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More information

Accepted/In Press date: 12 February 2021
e-pub ahead of print date: 21 April 2021
Additional Information: Funding Information: The LifeCycle project received funding from the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 733206 LifeCycle). All study specific acknowledgements and funding are presented in the supplementary material. This manuscript reflects only the author’s view and the Commission is not responsible for any use that may be made of the information it contains.
Keywords: Birth cohort, Cross-cohort collaboration, Data harmonisation, FAIR (findable, accessible, interoperable and reusable) principles, Lifecourse epidemiology

Identifiers

Local EPrints ID: 450375
URI: http://eprints.soton.ac.uk/id/eprint/450375
ISSN: 0393-2990
PURE UUID: daad8e63-efc1-41e8-99f1-a5f3d1eb655d
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749

Catalogue record

Date deposited: 26 Jul 2021 16:32
Last modified: 26 Nov 2021 02:44

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Contributors

Author: Angela Pinot de Moira
Author: Sido Haakma
Author: Katrine Strandberg-Larsen
Author: Marjolein Kooijman
Author: Tim Cadman
Author: Marloes Cardol
Author: Eva Corpeleijn
Author: Sarah Crozier ORCID iD
Author: Liesbeth Duijts
Author: Ahmed Elhakeem
Author: Johan G. Eriksson
Author: Janine F. Felix
Author: Sílvia Fernández-Barrés
Author: Rachel Foong
Author: Anne Forhan
Author: Veit Grote
Author: Kathrin Guerlich
Author: Barbara Heude
Author: Rae-Chi Huang
Author: Marjo-Riitta Järvelin
Author: Anne Cathrine Jørgensen
Author: Tuija M. Mikkola
Author: Johanna L. T. Nader
Author: Marie Pedersen
Author: Maja Popovic
Author: Nina Rautio
Author: Lorenzo Richiardi
Author: Theano Roumeliotaki
Author: Justiina Ronkainen
Author: Hazel Inskip ORCID iD

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