Gallium: new developments and applications in radiopharmaceutics
Gallium: new developments and applications in radiopharmaceutics
The chemistry of gallium has played a key role in nuclear medicine for half a century. Its applications have centered around two principal radionuclides, gallium-67 and gallium-68. Developments in the chemistry of gallium and its radionuclides in the last few years have led to advances in simple, convenient preparation of biomolecular conjugate-based radionuclides using novel chelating agents, including clinical applications; use of radionuclide imaging to elucidate the pharmacokinetics of gallium-based anticancer drugs; exploiting the biological chemistry of gallium as a basis for radionuclide imaging of cancer and microbial infection; potential use of gallium-67 as an Auger electron-emitting therapeutic radionuclide; and exploitation of the affinity of gallium for fluoride to develop simple methods for labeling biomolecules with the positron-emitting radionuclide fluorine-18. This review provides an update on each of these areas of gallium chemistry in the context of its interface with nuclear medicine, illustrated by recent collaborative contributions of the authors, who form a group of UK academic groups sharing common interests.
Gallium, Gallium-67, Gallium-68, Molecular imaging, Positron emission tomography
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Blower, Philip J.
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Cusnir, Ruslan
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Darwesh, Afnan
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Long, Nicholas J.
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Ma, Michelle T.
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Osborne, Bradley E.
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Price, Thomas W.
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Reid, Gillian
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Southworth, Richard
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Stasiuk, Graeme J.
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Terry, Samantha Y.A.
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de Rosales, Rafael Torres Martin
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Pelllico, Juan
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Blower, Philip J.
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Cusnir, Ruslan
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Darwesh, Afnan
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Long, Nicholas J.
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Ma, Michelle T.
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Osborne, Bradley E.
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Price, Thomas W.
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Reid, Gillian
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Southworth, Richard
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Stasiuk, Graeme J.
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Terry, Samantha Y.A.
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de Rosales, Rafael Torres Martin
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Pelllico, Juan
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Blower, Philip J., Cusnir, Ruslan, Darwesh, Afnan, Long, Nicholas J., Ma, Michelle T., Osborne, Bradley E., Price, Thomas W., Reid, Gillian, Southworth, Richard, Stasiuk, Graeme J., Terry, Samantha Y.A., de Rosales, Rafael Torres Martin and Pelllico, Juan
(2021)
Gallium: new developments and applications in radiopharmaceutics.
In,
Advances in Inorganic Chemistry.
(Advances in Inorganic Chemistry)
Academic Press, .
(doi:10.1016/bs.adioch.2021.04.002).
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Book Section
Abstract
The chemistry of gallium has played a key role in nuclear medicine for half a century. Its applications have centered around two principal radionuclides, gallium-67 and gallium-68. Developments in the chemistry of gallium and its radionuclides in the last few years have led to advances in simple, convenient preparation of biomolecular conjugate-based radionuclides using novel chelating agents, including clinical applications; use of radionuclide imaging to elucidate the pharmacokinetics of gallium-based anticancer drugs; exploiting the biological chemistry of gallium as a basis for radionuclide imaging of cancer and microbial infection; potential use of gallium-67 as an Auger electron-emitting therapeutic radionuclide; and exploitation of the affinity of gallium for fluoride to develop simple methods for labeling biomolecules with the positron-emitting radionuclide fluorine-18. This review provides an update on each of these areas of gallium chemistry in the context of its interface with nuclear medicine, illustrated by recent collaborative contributions of the authors, who form a group of UK academic groups sharing common interests.
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Accepted/In Press date: 18 April 2021
e-pub ahead of print date: 19 May 2021
Additional Information:
Funding Information:
This work was supported by the Wellcome/EPSRC Centre for Medical Engineering [WT203148/Z/16/Z], and by EPSRC Program Grant [#EP/S032789/1], and by King's College London and Imperial College London EPSRC Centre for Doctoral Training in Medical Imaging (EP/L015226/1).
Publisher Copyright:
© 2021 Elsevier Inc.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
Keywords:
Gallium, Gallium-67, Gallium-68, Molecular imaging, Positron emission tomography
Identifiers
Local EPrints ID: 450405
URI: http://eprints.soton.ac.uk/id/eprint/450405
ISSN: 0898-8838
PURE UUID: b0cd4969-368a-468c-999f-cfaa4210a0dd
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Date deposited: 27 Jul 2021 17:24
Last modified: 18 Mar 2024 02:39
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Contributors
Author:
Philip J. Blower
Author:
Ruslan Cusnir
Author:
Afnan Darwesh
Author:
Nicholas J. Long
Author:
Michelle T. Ma
Author:
Bradley E. Osborne
Author:
Thomas W. Price
Author:
Richard Southworth
Author:
Graeme J. Stasiuk
Author:
Samantha Y.A. Terry
Author:
Rafael Torres Martin de Rosales
Author:
Juan Pelllico
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