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Cancer-associated fibroblasts in oral cancer: A current perspective on function and potential for therapeutic targeting

Cancer-associated fibroblasts in oral cancer: A current perspective on function and potential for therapeutic targeting
Cancer-associated fibroblasts in oral cancer: A current perspective on function and potential for therapeutic targeting
The role of the tumour microenvironement (TME) in cancer progression and resistance to therapies is now widely recognized. The most prominent non-immune cell type in the microenvironment of oral cancer (OSCC) is cancer-associated fibroblasts (CAF). Although CAF are a poorly characterised and heterogenous cell population, those with an “activated” myofibroblastic phenotype have been shown to support OSCC progression, promoting growth, invasion and numerous other “hallmarks of malignancy.” CAF also confer broad resistance to different types of therapy, including chemo/radiotherapy and EGFR inhibitors; consistent with this, CAF-rich OSCC are associated with poor prognosis. In recent years, much CAF research has focused on their immunological role in the tumour microenvironment, showing that CAF shield tumours from immune attack through multiple mechanisms, and particularly on their role in promoting resistance to anti-PD-1/PD-L1 checkpoint inhibitors, an exciting development for the treatment of recurrent/metastatic oral cancer, but which fails in most patients. This review summarises our current understanding of CAF subtypes and function in OSCC and discusses the potential for targeting these cells therapeutically.
1-11
Bienkowska, Kamila, Justyna
42bd8057-5b06-4616-9b7c-c92e29e159f4
Hanley, Christopher J.
7e2d840d-e724-4389-a362-83741ccdf241
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Bienkowska, Kamila, Justyna
42bd8057-5b06-4616-9b7c-c92e29e159f4
Hanley, Christopher J.
7e2d840d-e724-4389-a362-83741ccdf241
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106

Bienkowska, Kamila, Justyna, Hanley, Christopher J. and Thomas, Gareth J. (2021) Cancer-associated fibroblasts in oral cancer: A current perspective on function and potential for therapeutic targeting. Frontiers in Oral Health, 2, 1-11, [686337]. (doi:10.3389/froh.2021.686337).

Record type: Review

Abstract

The role of the tumour microenvironement (TME) in cancer progression and resistance to therapies is now widely recognized. The most prominent non-immune cell type in the microenvironment of oral cancer (OSCC) is cancer-associated fibroblasts (CAF). Although CAF are a poorly characterised and heterogenous cell population, those with an “activated” myofibroblastic phenotype have been shown to support OSCC progression, promoting growth, invasion and numerous other “hallmarks of malignancy.” CAF also confer broad resistance to different types of therapy, including chemo/radiotherapy and EGFR inhibitors; consistent with this, CAF-rich OSCC are associated with poor prognosis. In recent years, much CAF research has focused on their immunological role in the tumour microenvironment, showing that CAF shield tumours from immune attack through multiple mechanisms, and particularly on their role in promoting resistance to anti-PD-1/PD-L1 checkpoint inhibitors, an exciting development for the treatment of recurrent/metastatic oral cancer, but which fails in most patients. This review summarises our current understanding of CAF subtypes and function in OSCC and discusses the potential for targeting these cells therapeutically.

Text
Bienkowska et al., 2021
Available under License Creative Commons Attribution.
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Published date: 1 July 2021

Identifiers

Local EPrints ID: 450439
URI: http://eprints.soton.ac.uk/id/eprint/450439
PURE UUID: 73b450b9-a784-4146-b398-4d4a37bd8867
ORCID for Christopher J. Hanley: ORCID iD orcid.org/0000-0003-3816-7220

Catalogue record

Date deposited: 28 Jul 2021 16:31
Last modified: 29 Jul 2021 01:44

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Contributors

Author: Kamila, Justyna Bienkowska

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