The immunometabolic roles of various fatty acids in macrophages and lymphocytes
The immunometabolic roles of various fatty acids in macrophages and lymphocytes
Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research.
Cytokines, Fatty acids, Immune cells, Inflammation, Leukocytes, Lipids, Lymphocytes, Macrophages, Metabolism
Neto, Jose Cesar Rosa
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Calder, Philip
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Curi, Rui
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Newsholme, Philip
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Sethi, Jaswinder K.
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Silveira, Loreana S.
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6 August 2021
Neto, Jose Cesar Rosa
a14b6c54-d498-4c6b-ace2-c8727c3eb953
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Curi, Rui
e53c83ce-b727-4b87-91ef-cff9272ffa36
Newsholme, Philip
1e3af381-d0a1-43b8-a583-90ca6e9b4db6
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Silveira, Loreana S.
499afabb-5c90-4aac-82fb-efeb632a36a8
Neto, Jose Cesar Rosa, Calder, Philip, Curi, Rui, Newsholme, Philip, Sethi, Jaswinder K. and Silveira, Loreana S.
(2021)
The immunometabolic roles of various fatty acids in macrophages and lymphocytes.
International Journal of Molecular Sciences, 22 (16), [8460].
(doi:10.3390/ijms22168460).
Abstract
Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent partly on their state of activation and partly on the availability of various energy yielding and biosynthetic substrates (fatty acids, glucose, and amino acids). These substrates are essential to fuel-based metabolic reprogramming that supports optimal immune function, including the inflammatory response. In this review, we will focus on metabolism in macrophages and lymphocytes and discuss the role of fatty acids in governing the phenotype, activation, and functional status of these important cells. We summarize the current understanding of the pathways of fatty acid metabolism and related mechanisms of action and also explore possible new perspectives in this exciting area of research.
Text
ijms-1292261 (1)_Revised
- Accepted Manuscript
More information
Accepted/In Press date: 19 July 2021
Published date: 6 August 2021
Additional Information:
Funding Information:
This research received no funding. The APC was funded by Funda??o ? Pesquisa do Estado de S?o Paulo (FAPESP) (Grant numbers FAPESP: 2019/09679-2 and FAPESP: 2019/09854-9).
Funding Information:
Acknowledgments: J.C.R.N. is funded by Fundação à Pesquisa do Estado de São Paulo. Figures were created with Biorender.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords:
Cytokines, Fatty acids, Immune cells, Inflammation, Leukocytes, Lipids, Lymphocytes, Macrophages, Metabolism
Identifiers
Local EPrints ID: 450457
URI: http://eprints.soton.ac.uk/id/eprint/450457
ISSN: 1422-0067
PURE UUID: 69765c98-5881-4fea-82a1-a1f776dae55a
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Date deposited: 28 Jul 2021 16:32
Last modified: 17 Mar 2024 06:43
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Contributors
Author:
Jose Cesar Rosa Neto
Author:
Rui Curi
Author:
Philip Newsholme
Author:
Loreana S. Silveira
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