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The immunometabolic roles of various fatty acids in macrophages and lymphocytes

The immunometabolic roles of various fatty acids in macrophages and lymphocytes
The immunometabolic roles of various fatty acids in macrophages and lymphocytes
Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent 19 partly on their state of activation and partly on the availability of various energy yielding and bio-20 synthetic substrates (fatty acids, glucose and amino acids). These substrates are essential to fuel-21 based metabolic reprogramming that is supports optimal immune function, including the inflam-22 matory response. In this review, we will focus on metabolism in macrophages and lymphocytes and 23 discuss the role of fatty acids in governing the phenotype, activation and functional status of these 24 important cells. We summarize the current understanding of the pathways of fatty acid metabolism 25 and related mechanisms of action as well as explore possible new perspectives in this exciting area 26 of research. 27
1422-0067
Neto, Jose Cesar Rosa
a14b6c54-d498-4c6b-ace2-c8727c3eb953
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Curi, Rui
e53c83ce-b727-4b87-91ef-cff9272ffa36
Newsholme, Philip
1e3af381-d0a1-43b8-a583-90ca6e9b4db6
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Silveira, Loreana S.
499afabb-5c90-4aac-82fb-efeb632a36a8
Neto, Jose Cesar Rosa
a14b6c54-d498-4c6b-ace2-c8727c3eb953
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Curi, Rui
e53c83ce-b727-4b87-91ef-cff9272ffa36
Newsholme, Philip
1e3af381-d0a1-43b8-a583-90ca6e9b4db6
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Silveira, Loreana S.
499afabb-5c90-4aac-82fb-efeb632a36a8

Neto, Jose Cesar Rosa, Calder, Philip, Curi, Rui, Newsholme, Philip, Sethi, Jaswinder K. and Silveira, Loreana S. (2021) The immunometabolic roles of various fatty acids in macrophages and lymphocytes. International Journal of Molecular Sciences. (doi:10.3390/ijms22168460).

Record type: Review

Abstract

Macrophages and lymphocytes demonstrate metabolic plasticity, which is dependent 19 partly on their state of activation and partly on the availability of various energy yielding and bio-20 synthetic substrates (fatty acids, glucose and amino acids). These substrates are essential to fuel-21 based metabolic reprogramming that is supports optimal immune function, including the inflam-22 matory response. In this review, we will focus on metabolism in macrophages and lymphocytes and 23 discuss the role of fatty acids in governing the phenotype, activation and functional status of these 24 important cells. We summarize the current understanding of the pathways of fatty acid metabolism 25 and related mechanisms of action as well as explore possible new perspectives in this exciting area 26 of research. 27

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ijms-1292261 (1)_Revised - Accepted Manuscript
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Accepted/In Press date: 19 July 2021
Published date: 6 August 2021
Additional Information: Jose Cesar Rosa Neto, Rui Curi, Philip Newsholme

Identifiers

Local EPrints ID: 450457
URI: http://eprints.soton.ac.uk/id/eprint/450457
ISSN: 1422-0067
PURE UUID: 69765c98-5881-4fea-82a1-a1f776dae55a
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X
ORCID for Jaswinder K. Sethi: ORCID iD orcid.org/0000-0003-4157-0475

Catalogue record

Date deposited: 28 Jul 2021 16:32
Last modified: 13 Oct 2021 04:01

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Contributors

Author: Jose Cesar Rosa Neto
Author: Philip Calder ORCID iD
Author: Rui Curi
Author: Philip Newsholme
Author: Loreana S. Silveira

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