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Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder

Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder
Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder
Background: vaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J). The evaluation and management of suspected cases of CVT post COVID-19 vaccination are critical skills for a broad range of healthcare providers. Methods: a collaborative comprehensive review of literature was conducted among a global group of expert neurologists and hematologists. Findings: strategies for rapid evaluation and treatment of the CVT in the context of possible VITT exist, including inflammatory marker measurements, PF4 assays, and non-heparin anticoagulation.
0022-3050
Butler, Matthew
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Tamborska, Arina
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Wood, Greta K
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Ellul, Mark
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Thomas, Rhys
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Galea, Ian
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Pett, Sarah
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Singh, Bhagteshwar
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Solomon, Tom
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Pollak, Thomas
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Michael, Benedict D
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Nicholson, Tim
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Butler, Matthew
240a7201-5c01-4f10-b7a1-5e31c56bad01
Tamborska, Arina
cb87d726-19cb-4cdd-865b-b08917808261
Wood, Greta K
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Ellul, Mark
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Thomas, Rhys
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Galea, Ian
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Pett, Sarah
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Singh, Bhagteshwar
3e165108-df71-4c99-a9e6-3c1eddd14f39
Solomon, Tom
3311a8fe-fc3d-42ab-8c99-cacc179f1f77
Pollak, Thomas
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Michael, Benedict D
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Nicholson, Tim
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Butler, Matthew, Tamborska, Arina, Wood, Greta K, Ellul, Mark, Thomas, Rhys, Galea, Ian, Pett, Sarah, Singh, Bhagteshwar, Solomon, Tom, Pollak, Thomas, Michael, Benedict D and Nicholson, Tim (2021) Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder. Journal of Neurology, Neurosurgery, and Psychiatry. (doi:10.1016/j.jns.2021.117532).

Record type: Article

Abstract

Background: vaccine induced immune mediated thrombocytopenia or VITT, is a recent and rare phenomenon of thrombosis with thrombocytopenia, frequently including cerebral venous thromboses (CVT), that has been described following vaccination with adenovirus vaccines ChAdOx1 nCOV-19 (AstraZeneca) and Ad26.COV2·S Johnson and Johnson (Janssen/J&J). The evaluation and management of suspected cases of CVT post COVID-19 vaccination are critical skills for a broad range of healthcare providers. Methods: a collaborative comprehensive review of literature was conducted among a global group of expert neurologists and hematologists. Findings: strategies for rapid evaluation and treatment of the CVT in the context of possible VITT exist, including inflammatory marker measurements, PF4 assays, and non-heparin anticoagulation.

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PIIS0022510X21002264 - Version of Record
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e-pub ahead of print date: 4 June 2021

Identifiers

Local EPrints ID: 450520
URI: http://eprints.soton.ac.uk/id/eprint/450520
ISSN: 0022-3050
PURE UUID: 6750caa1-d365-47b7-8d7f-3bcce9c4799f
ORCID for Ian Galea: ORCID iD orcid.org/0000-0002-1268-5102

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Date deposited: 02 Aug 2021 16:32
Last modified: 03 Aug 2021 01:37

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Contributors

Author: Matthew Butler
Author: Arina Tamborska
Author: Greta K Wood
Author: Mark Ellul
Author: Rhys Thomas
Author: Ian Galea ORCID iD
Author: Sarah Pett
Author: Bhagteshwar Singh
Author: Tom Solomon
Author: Thomas Pollak
Author: Benedict D Michael
Author: Tim Nicholson

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