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Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study

Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study
Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study
Many observational studies and some randomized trials demonstrate how fetal growth can be influenced by environmental insults (for example, maternal infections)1 and preventive interventions (for example, multiple-micronutrient supplementation)2 that can have a long-lasting effect on health, growth, neurodevelopment and even educational attainment and income in adulthood3. In a cohort of pregnant women (n = 3,598), followed-up between 2012 and 2019 at six sites worldwide4, we studied the associations between ultrasound-derived fetal cranial growth trajectories, measured longitudinally from <14 weeks’ gestation, against international standards5,6, and growth and neurodevelopment up to 2 years of age7,8. We identified five trajectories associated with specific neurodevelopmental, behavioral, visual and growth outcomes, independent of fetal abdominal growth, postnatal morbidity and anthropometric measures at birth and age 2. The trajectories, which changed within a 20–25-week gestational age window, were associated with brain development at 2 years of age according to a mirror (positive/negative) pattern, mostly focused on maturation of cognitive, language and visual skills. Further research should explore the potential for preventive interventions in pregnancy to improve infant neurodevelopmental outcomes before the critical window of opportunity that precedes the divergence of growth at 20–25 weeks’ gestation.
1078-8956
647-652
Villar, José
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Gunier, Robert B.
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Tshivuila-Matala, Chrystelle O.O.
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Rauch, Stephen A.
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Nosten, Francois
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Ochieng, Roseline
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Restrepo-Méndez, María C.
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McGready, Rose
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Barros, Fernando C.
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Fernandes, Michelle
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Carrara, Verena I.
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Victora, Cesar G.
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Munim, Shama
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Craik, Rachel
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Barsosio, Hellen C.
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Carvalho, Maria
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Berkley, James A.
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Cheikh Ismail, Leila
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Norris, Shane A.
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Ohuma, Eric O.
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Stein, Alan
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Lambert, Ann
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Winsey, Adele
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Uauy, Ricardo
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Eskenazi, Brenda
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Bhutta, Zulfiqar A.
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Papageorghiou, Aris T.
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Kennedy, Stephen H.
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Villar, José
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Gunier, Robert B.
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Tshivuila-Matala, Chrystelle O.O.
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Rauch, Stephen A.
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Nosten, Francois
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Ochieng, Roseline
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Restrepo-Méndez, María C.
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McGready, Rose
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Barros, Fernando C.
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Fernandes, Michelle
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Carrara, Verena I.
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Victora, Cesar G.
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Munim, Shama
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Craik, Rachel
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Barsosio, Hellen C.
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Carvalho, Maria
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Berkley, James A.
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Cheikh Ismail, Leila
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Norris, Shane A.
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Ohuma, Eric O.
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Stein, Alan
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Lambert, Ann
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Winsey, Adele
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Uauy, Ricardo
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Eskenazi, Brenda
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Bhutta, Zulfiqar A.
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Papageorghiou, Aris T.
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Kennedy, Stephen H.
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Villar, José, Gunier, Robert B., Tshivuila-Matala, Chrystelle O.O., Rauch, Stephen A., Nosten, Francois, Ochieng, Roseline, Restrepo-Méndez, María C., McGready, Rose, Barros, Fernando C., Fernandes, Michelle, Carrara, Verena I., Victora, Cesar G., Munim, Shama, Craik, Rachel, Barsosio, Hellen C., Carvalho, Maria, Berkley, James A., Cheikh Ismail, Leila, Norris, Shane A., Ohuma, Eric O., Stein, Alan, Lambert, Ann, Winsey, Adele, Uauy, Ricardo, Eskenazi, Brenda, Bhutta, Zulfiqar A., Papageorghiou, Aris T. and Kennedy, Stephen H. (2021) Fetal cranial growth trajectories are associated with growth and neurodevelopment at 2 years of age: INTERBIO-21st Fetal Study. Nature Medicine, 27 (4), 647-652. (doi:10.1038/s41591-021-01280-2).

Record type: Article

Abstract

Many observational studies and some randomized trials demonstrate how fetal growth can be influenced by environmental insults (for example, maternal infections)1 and preventive interventions (for example, multiple-micronutrient supplementation)2 that can have a long-lasting effect on health, growth, neurodevelopment and even educational attainment and income in adulthood3. In a cohort of pregnant women (n = 3,598), followed-up between 2012 and 2019 at six sites worldwide4, we studied the associations between ultrasound-derived fetal cranial growth trajectories, measured longitudinally from <14 weeks’ gestation, against international standards5,6, and growth and neurodevelopment up to 2 years of age7,8. We identified five trajectories associated with specific neurodevelopmental, behavioral, visual and growth outcomes, independent of fetal abdominal growth, postnatal morbidity and anthropometric measures at birth and age 2. The trajectories, which changed within a 20–25-week gestational age window, were associated with brain development at 2 years of age according to a mirror (positive/negative) pattern, mostly focused on maturation of cognitive, language and visual skills. Further research should explore the potential for preventive interventions in pregnancy to improve infant neurodevelopmental outcomes before the critical window of opportunity that precedes the divergence of growth at 20–25 weeks’ gestation.

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Villar et al Nature Medicine fetal trajectories neurodev Mar 2021 - Version of Record
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More information

Accepted/In Press date: 5 February 2021
e-pub ahead of print date: 18 March 2021

Identifiers

Local EPrints ID: 450681
URI: http://eprints.soton.ac.uk/id/eprint/450681
ISSN: 1078-8956
PURE UUID: 72b868ab-7c6f-42a3-af53-2cd02aa98479
ORCID for Michelle Fernandes: ORCID iD orcid.org/0000-0002-0051-3389
ORCID for Shane A. Norris: ORCID iD orcid.org/0000-0001-7124-3788

Catalogue record

Date deposited: 06 Aug 2021 16:31
Last modified: 06 Jun 2024 02:12

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Contributors

Author: José Villar
Author: Robert B. Gunier
Author: Chrystelle O.O. Tshivuila-Matala
Author: Stephen A. Rauch
Author: Francois Nosten
Author: Roseline Ochieng
Author: María C. Restrepo-Méndez
Author: Rose McGready
Author: Fernando C. Barros
Author: Michelle Fernandes ORCID iD
Author: Verena I. Carrara
Author: Cesar G. Victora
Author: Shama Munim
Author: Rachel Craik
Author: Hellen C. Barsosio
Author: Maria Carvalho
Author: James A. Berkley
Author: Leila Cheikh Ismail
Author: Shane A. Norris ORCID iD
Author: Eric O. Ohuma
Author: Alan Stein
Author: Ann Lambert
Author: Adele Winsey
Author: Ricardo Uauy
Author: Brenda Eskenazi
Author: Zulfiqar A. Bhutta
Author: Aris T. Papageorghiou
Author: Stephen H. Kennedy

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