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Tropisetron versus Metoclopramide in the control of emesis in far-advanced cancer

Tropisetron versus Metoclopramide in the control of emesis in far-advanced cancer
Tropisetron versus Metoclopramide in the control of emesis in far-advanced cancer
The present study was conducted to assess the optimum treatment for nausea and vomiting in patients with far advanced cancer. More specifically, we studied patients with cancers that were too far advanced to benefit from chemotherapy or radiotherapy and whose nausea and vomiting were not due to drug intake, cranial, electrolytic, or metabolic causes. One hundred twenty patients who were under antiemetic medication with metoclopramide (MET) and suddenly presented with uncontrolled nausea and vomiting were randomized to three different therapeutic regimens: MET plus dexamethasone (DEX), MET plus tropisetron (TRO), and MET plus TRO plus DEX. Patient diary cards were used to assess nausea and vomiting. By the end of day 15, total control of vomiting was achieved in 24% of MET plus DEX patients, in 84% of MET plus TRO patients, and in 92% of MET plus TRO plus DEX patients. Total control of nausea was achieved in 18% of MET plus DEX patients, in 74% of MET plus TRO patients, and in 87% of MET plus TRO plus DEX patients. All antiemetic treatments were similarly well tolerated. TRO in combination with either MET or MET and DEX produced the best control of both nausea and vomiting.
far advanced cancer, emesis, nausea, vomiting, tropisetron, metoclopramide
1083-7159
319-323
Mystakidou, K.
f68d2615-d159-425e-aa5d-3f68c1a3146a
Befon, S.
6ad4e0be-90f2-42e6-a5cc-a11fbf77c6f1
Trifyllis, J.
2824a960-c2bf-4857-82e7-5892310d62c7
Liossi, C.
fd401ad6-581a-4a31-a60b-f8671ffd3558
Papadimitriou, J.
dd245334-83d8-42e0-991f-8fdf2e516d90
Mystakidou, K.
f68d2615-d159-425e-aa5d-3f68c1a3146a
Befon, S.
6ad4e0be-90f2-42e6-a5cc-a11fbf77c6f1
Trifyllis, J.
2824a960-c2bf-4857-82e7-5892310d62c7
Liossi, C.
fd401ad6-581a-4a31-a60b-f8671ffd3558
Papadimitriou, J.
dd245334-83d8-42e0-991f-8fdf2e516d90

Mystakidou, K., Befon, S., Trifyllis, J., Liossi, C. and Papadimitriou, J. (1997) Tropisetron versus Metoclopramide in the control of emesis in far-advanced cancer. The Oncologist, 2 (5), 319-323.

Record type: Article

Abstract

The present study was conducted to assess the optimum treatment for nausea and vomiting in patients with far advanced cancer. More specifically, we studied patients with cancers that were too far advanced to benefit from chemotherapy or radiotherapy and whose nausea and vomiting were not due to drug intake, cranial, electrolytic, or metabolic causes. One hundred twenty patients who were under antiemetic medication with metoclopramide (MET) and suddenly presented with uncontrolled nausea and vomiting were randomized to three different therapeutic regimens: MET plus dexamethasone (DEX), MET plus tropisetron (TRO), and MET plus TRO plus DEX. Patient diary cards were used to assess nausea and vomiting. By the end of day 15, total control of vomiting was achieved in 24% of MET plus DEX patients, in 84% of MET plus TRO patients, and in 92% of MET plus TRO plus DEX patients. Total control of nausea was achieved in 18% of MET plus DEX patients, in 74% of MET plus TRO patients, and in 87% of MET plus TRO plus DEX patients. All antiemetic treatments were similarly well tolerated. TRO in combination with either MET or MET and DEX produced the best control of both nausea and vomiting.

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More information

Published date: 1997
Keywords: far advanced cancer, emesis, nausea, vomiting, tropisetron, metoclopramide

Identifiers

Local EPrints ID: 45073
URI: http://eprints.soton.ac.uk/id/eprint/45073
ISSN: 1083-7159
PURE UUID: 590c1529-eda0-4963-8120-4d30551a403f
ORCID for C. Liossi: ORCID iD orcid.org/0000-0003-0627-6377

Catalogue record

Date deposited: 27 Mar 2007
Last modified: 23 Jul 2022 01:55

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Contributors

Author: K. Mystakidou
Author: S. Befon
Author: J. Trifyllis
Author: C. Liossi ORCID iD
Author: J. Papadimitriou

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