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Osteoporosis and fractures in women: the burden of disease

Osteoporosis and fractures in women: the burden of disease
Osteoporosis and fractures in women: the burden of disease

Osteoporosis is a disease characterized by impaired bone microarchitecture and reduced bone mineral density (BMD) resulting in bone fragility and increased risk of fracture. In western societies, one in three women and one in five men will sustain an osteoporotic fracture in their remaining lifetime from the age of 50 years. Fragility fractures, especially of the spine and hip, commonly give rise to increased morbidity and mortality. In the five largest European countries and Sweden, fragility fractures were the cause of 2.6 million disability-adjusted life years in 2016 and the fracture-related costs increased from €29.6 billion in 2010 to €37.5 billion in 2017. In the European Union and the USA, only a small proportion of women eligible for pharmacological treatment are being prescribed osteoporosis medication. Secondary fracture prevention, using Fracture Liaison Services, can be used to increase the rates of fracture risk assessment, BMD testing and use of osteoporosis medication in order to reduce fracture numbers. Additionally, established primary prevention strategies, based on case-finding methods utilizing fracture prediction tools, such as FRAX, to identify women without fracture but with elevated risk, are recommended in order to further reduce fracture numbers.

Osteoporosis, epidemiology, fracture, postmenopausal
1369-7137
Lorentzon, M.
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Johansson, H.
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Harvey, Nicholas
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Liu, E.
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Vandenput, Lisbeth
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McCloskey, E. V.
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Kanis, J. A.
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Lorentzon, M.
11692e10-5916-4bb5-86c5-3ff9ccd77af6
Johansson, H.
05aa5476-bcb9-4b97-905e-00f1dfd9d691
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Liu, E.
63b60e12-5d42-4f66-ba55-24da69557b35
Vandenput, Lisbeth
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McCloskey, E. V.
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Kanis, J. A.
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Lorentzon, M., Johansson, H., Harvey, Nicholas, Liu, E., Vandenput, Lisbeth, McCloskey, E. V. and Kanis, J. A. (2021) Osteoporosis and fractures in women: the burden of disease. Climacteric. (doi:10.1080/13697137.2021.1951206).

Record type: Review

Abstract

Osteoporosis is a disease characterized by impaired bone microarchitecture and reduced bone mineral density (BMD) resulting in bone fragility and increased risk of fracture. In western societies, one in three women and one in five men will sustain an osteoporotic fracture in their remaining lifetime from the age of 50 years. Fragility fractures, especially of the spine and hip, commonly give rise to increased morbidity and mortality. In the five largest European countries and Sweden, fragility fractures were the cause of 2.6 million disability-adjusted life years in 2016 and the fracture-related costs increased from €29.6 billion in 2010 to €37.5 billion in 2017. In the European Union and the USA, only a small proportion of women eligible for pharmacological treatment are being prescribed osteoporosis medication. Secondary fracture prevention, using Fracture Liaison Services, can be used to increase the rates of fracture risk assessment, BMD testing and use of osteoporosis medication in order to reduce fracture numbers. Additionally, established primary prevention strategies, based on case-finding methods utilizing fracture prediction tools, such as FRAX, to identify women without fracture but with elevated risk, are recommended in order to further reduce fracture numbers.

Text
Osteoporosis and fractures in women Climacteric - Accepted Manuscript
Restricted to Repository staff only until 28 July 2022.
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More information

Accepted/In Press date: 17 June 2021
e-pub ahead of print date: 28 July 2021
Keywords: Osteoporosis, epidemiology, fracture, postmenopausal

Identifiers

Local EPrints ID: 450745
URI: http://eprints.soton.ac.uk/id/eprint/450745
ISSN: 1369-7137
PURE UUID: d7f56a22-d924-4b76-8c5f-f2baaac89945
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 10 Aug 2021 16:30
Last modified: 26 Nov 2021 02:48

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Contributors

Author: M. Lorentzon
Author: H. Johansson
Author: Nicholas Harvey ORCID iD
Author: E. Liu
Author: Lisbeth Vandenput
Author: E. V. McCloskey
Author: J. A. Kanis

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