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Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank.

Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank.
Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank.
Objective: It remains unclear how the different features of radiographic hip osteoarthritis (rHOA) contribute to hip pain. We examined the relationship between rHOA, including its individual components, and hip pain using a novel dual-energy x-ray absorptiometry (DXA)-based method.

Methods: Hip DXAs were obtained from UK Biobank. A novel automated method obtained minimum joint space width (mJSW) from points placed around the femoral head and acetabulum. Osteophyte areas at the lateral acetabulum, superior and inferior femoral head were derived manually. Semi-quantitative measures of osteophytes and joint space narrowing (JSN) were combined to define rHOA. Logistic regression was used to examine the relationships between these variables and hip pain, obtained via questionnaires.

Results: 6807 hip DXAs were examined. rHOA was present in 353 (5.2%) individuals and was associated with hip pain [OR 2.42 (1.78-3.29)] and hospital diagnosed OA [6.01 (2.98-12.16)]. Total osteophyte area but not mJSW was associated with hip pain in mutually adjusted models [1.31 (1.23-1.39), 0.95 (0.87-1.04) respectively]. On the other hand, JSN as a categorical variable showed weak associations between grade ≥ 1 and grade ≥ 2 JSN with hip pain [1.30 (1.06-1.60), 1.80 (1.34-2.42) respectively]. Acetabular, superior and inferior femoral osteophyte areas were all independently associated with hip pain [1.13 (1.06-1.20), 1.13 (1.05-1.24), 1.10 (1.03-1.17) respectively].

Conclusion: In this cohort, the relationship between rHOA and prevalent hip pain was explained by 2-dimensional osteophyte area, but not by the apparent mJSW. Osteophytes at different locations showed important, potentially independent, associations with hip pain, possibly reflecting the contribution of distinct biomechanical pathways.
Dual-energy x-ray absorptiometry, Hip pain, Joint space narrowing, Osteoarthritis, Osteophyte
8756-3282
Faber, Benjamin
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Ebsim, Raja
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Saunders, Fiona R.
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Frysz, Monika
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Lindner, Claudia
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Gregory, Jennifer S.
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Aspden, Richard M.
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Harvey, Nicholas
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Davey Smith, George
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Cootes, Timothy
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Tobias, Jonathan H.
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Faber, Benjamin
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Ebsim, Raja
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Saunders, Fiona R.
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Frysz, Monika
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Lindner, Claudia
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Gregory, Jennifer S.
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Aspden, Richard M.
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Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Davey Smith, George
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Cootes, Timothy
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Tobias, Jonathan H.
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Faber, Benjamin, Ebsim, Raja, Saunders, Fiona R., Frysz, Monika, Lindner, Claudia, Gregory, Jennifer S., Aspden, Richard M., Harvey, Nicholas, Davey Smith, George, Cootes, Timothy and Tobias, Jonathan H. (2021) Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank. Bone, 153, [116146]. (doi:10.1016/j.bone.2021.116146).

Record type: Article

Abstract

Objective: It remains unclear how the different features of radiographic hip osteoarthritis (rHOA) contribute to hip pain. We examined the relationship between rHOA, including its individual components, and hip pain using a novel dual-energy x-ray absorptiometry (DXA)-based method.

Methods: Hip DXAs were obtained from UK Biobank. A novel automated method obtained minimum joint space width (mJSW) from points placed around the femoral head and acetabulum. Osteophyte areas at the lateral acetabulum, superior and inferior femoral head were derived manually. Semi-quantitative measures of osteophytes and joint space narrowing (JSN) were combined to define rHOA. Logistic regression was used to examine the relationships between these variables and hip pain, obtained via questionnaires.

Results: 6807 hip DXAs were examined. rHOA was present in 353 (5.2%) individuals and was associated with hip pain [OR 2.42 (1.78-3.29)] and hospital diagnosed OA [6.01 (2.98-12.16)]. Total osteophyte area but not mJSW was associated with hip pain in mutually adjusted models [1.31 (1.23-1.39), 0.95 (0.87-1.04) respectively]. On the other hand, JSN as a categorical variable showed weak associations between grade ≥ 1 and grade ≥ 2 JSN with hip pain [1.30 (1.06-1.60), 1.80 (1.34-2.42) respectively]. Acetabular, superior and inferior femoral osteophyte areas were all independently associated with hip pain [1.13 (1.06-1.20), 1.13 (1.05-1.24), 1.10 (1.03-1.17) respectively].

Conclusion: In this cohort, the relationship between rHOA and prevalent hip pain was explained by 2-dimensional osteophyte area, but not by the apparent mJSW. Osteophytes at different locations showed important, potentially independent, associations with hip pain, possibly reflecting the contribution of distinct biomechanical pathways.

Text
rHOA vs Hip Pain 7k revisions 26.7.21 clean - Accepted Manuscript
Restricted to Repository staff only until 6 August 2022.
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Accepted/In Press date: 6 August 2021
Published date: 6 August 2021
Additional Information: Financial support BGF is supported by a Medical Research Council (MRC) clinical research training fellowship (MR/S021280/1). RE, MF, FS are supported, and this work is funded by a Wellcome Trust collaborative award (reference number 209233). CL was funded by the MRC, UK (MR/S00405X/1). NCH acknowledges support from the MRC and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton. George Davey Smith works in the MRC Integrative Epidemiology Unit at the University of Bristol, which is supported by the MRC (MC_UU_00011/1).
Keywords: Dual-energy x-ray absorptiometry, Hip pain, Joint space narrowing, Osteoarthritis, Osteophyte

Identifiers

Local EPrints ID: 450962
URI: http://eprints.soton.ac.uk/id/eprint/450962
ISSN: 8756-3282
PURE UUID: db7a4a27-15c0-4167-ba57-18aa522917a5
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 26 Aug 2021 16:33
Last modified: 26 Nov 2021 02:48

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Contributors

Author: Benjamin Faber
Author: Raja Ebsim
Author: Fiona R. Saunders
Author: Monika Frysz
Author: Claudia Lindner
Author: Jennifer S. Gregory
Author: Richard M. Aspden
Author: Nicholas Harvey ORCID iD
Author: George Davey Smith
Author: Timothy Cootes
Author: Jonathan H. Tobias

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