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Etiological and epidemiological features of acute respiratory infections in China

Etiological and epidemiological features of acute respiratory infections in China
Etiological and epidemiological features of acute respiratory infections in China

Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children <5 years old and school-age children have the highest viral positivity rate (46.9%) and bacterial positivity rate (30.9%). Influenza virus, respiratory syncytial virus and human rhinovirus are the three leading viral pathogens with proportions of 28.5%, 16.8% and 16.7%, and Streptococcus pneumoniae, Mycoplasma pneumoniae and Klebsiella pneumoniae are the three leading bacterial pathogens (29.9%, 18.6% and 15.8%). Negative interactions between viruses and positive interactions between viral and bacterial pathogens are common. A Join-Point analysis reveals the age-specific positivity rate and how this varied for individual pathogens. These data indicate that differential priorities for diagnosis, prevention and control should be highlighted in terms of acute respiratory tract infection patients' demography, geographic locations and season of illness in China.

2041-1723
5026
Li, Zhong-Jie
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Zhang, Hai-Yang
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Lu, Qing-Bin
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Wang, Yi-Fei
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Lin, Sheng-Hong
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Zhang, Xiao-Ai
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Li, Jun
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Zhao, Shi-Wen
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Yi, Zhi-Gang
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Meng, Lei
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Lai, Sheng-Jie
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Jiang, Tao
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Yang, Yang
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Ward, Michael P
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Feng, Lu-Zhao
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Jing, Huai-Qi
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Xu, Wen-Bo
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Chen, Yu
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Wu, Jian-Guo
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Yuan, Zheng-Hong
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Li, Meng-Feng
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Wang, Li-Ping
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Liu, Wei
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Gao, George F
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Yang, Wei-Zhong
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Chinese Centers for Disease Control and Prevention (CDC) Etiology of Respiratory Infection Surveillance Study Team
Li, Zhong-Jie
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Zhang, Hai-Yang
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Ren, Li-Li
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Lu, Qing-Bin
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Ren, Xiang
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Zhang, Cui-Hong
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Wang, Yi-Fei
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Lin, Sheng-Hong
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Zhang, Xiao-Ai
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Li, Jun
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Zhao, Shi-Wen
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Yi, Zhi-Gang
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Chen, Xiao
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Wang, Xin-Hua
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Liu, Ying-Le
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Wang, Xin
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Cui, Ai-Li
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Lai, Sheng-Jie
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Jiang, Tao
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Yuan, Yang
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Shi, Lu-Sha
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Liu, Meng-Yang
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Zhu, Yu-Liang
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Zhang, An-Ran
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Zhang, Zhi-Jie
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Yang, Yang
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Ward, Michael P
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Feng, Lu-Zhao
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Jing, Huai-Qi
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Huang, Liu-Yu
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Xu, Wen-Bo
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Chen, Yu
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Wu, Jian-Guo
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Yuan, Zheng-Hong
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Li, Meng-Feng
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Wang, Yu
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Wang, Li-Ping
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Fang, Li-Qun
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Liu, Wei
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Hay, Simon I
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Gao, George F
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Yang, Wei-Zhong
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Chinese Centers for Disease Control and Prevention (CDC) Etiology of Respiratory Infection Surveillance Study Team (2021) Etiological and epidemiological features of acute respiratory infections in China. Nature Communications, 12 (1), 5026, [5026]. (doi:10.1038/s41467-021-25120-6).

Record type: Article

Abstract

Nationwide prospective surveillance of all-age patients with acute respiratory infections was conducted in China between 2009‒2019. Here we report the etiological and epidemiological features of the 231,107 eligible patients enrolled in this analysis. Children <5 years old and school-age children have the highest viral positivity rate (46.9%) and bacterial positivity rate (30.9%). Influenza virus, respiratory syncytial virus and human rhinovirus are the three leading viral pathogens with proportions of 28.5%, 16.8% and 16.7%, and Streptococcus pneumoniae, Mycoplasma pneumoniae and Klebsiella pneumoniae are the three leading bacterial pathogens (29.9%, 18.6% and 15.8%). Negative interactions between viruses and positive interactions between viral and bacterial pathogens are common. A Join-Point analysis reveals the age-specific positivity rate and how this varied for individual pathogens. These data indicate that differential priorities for diagnosis, prevention and control should be highlighted in terms of acute respiratory tract infection patients' demography, geographic locations and season of illness in China.

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More information

Submitted date: 8 March 2021
Accepted/In Press date: 26 July 2021
Published date: 18 August 2021
Additional Information: Funding Information: The authors thank all the subjects, their families, and collaborating clinicians for their participation. We thank staff members of the Department of Science and Education of the National Health Commission, and the ARIs surveillance network laboratories and sentinel hospitals in the participating 31 provinces of China for assistance with field investigation, administration, and data collection. This work was supported by grants from the China Mega-Project on Infectious Disease Prevention (grant number 2018ZX10713001, 2018ZX10713002, 2018ZX10201001, and 2017ZX10103004), and the National Natural Science Funds (grant number 91846302, 81825019). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © 2021, The Author(s).

Identifiers

Local EPrints ID: 451160
URI: http://eprints.soton.ac.uk/id/eprint/451160
ISSN: 2041-1723
PURE UUID: a721aadb-dcd7-4896-8316-8fa619e434c9
ORCID for Sheng-Jie Lai: ORCID iD orcid.org/0000-0001-9781-8148

Catalogue record

Date deposited: 14 Sep 2021 15:31
Last modified: 14 May 2024 01:55

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Contributors

Author: Zhong-Jie Li
Author: Hai-Yang Zhang
Author: Li-Li Ren
Author: Qing-Bin Lu
Author: Xiang Ren
Author: Cui-Hong Zhang
Author: Yi-Fei Wang
Author: Sheng-Hong Lin
Author: Xiao-Ai Zhang
Author: Jun Li
Author: Shi-Wen Zhao
Author: Zhi-Gang Yi
Author: Xiao Chen
Author: Zuo-Sen Yang
Author: Lei Meng
Author: Xin-Hua Wang
Author: Ying-Le Liu
Author: Xin Wang
Author: Ai-Li Cui
Author: Sheng-Jie Lai ORCID iD
Author: Tao Jiang
Author: Yang Yuan
Author: Lu-Sha Shi
Author: Meng-Yang Liu
Author: Yu-Liang Zhu
Author: An-Ran Zhang
Author: Zhi-Jie Zhang
Author: Yang Yang
Author: Michael P Ward
Author: Lu-Zhao Feng
Author: Huai-Qi Jing
Author: Liu-Yu Huang
Author: Wen-Bo Xu
Author: Yu Chen
Author: Jian-Guo Wu
Author: Zheng-Hong Yuan
Author: Meng-Feng Li
Author: Yu Wang
Author: Li-Ping Wang
Author: Li-Qun Fang
Author: Wei Liu
Author: Simon I Hay
Author: George F Gao
Author: Wei-Zhong Yang
Corporate Author: Chinese Centers for Disease Control and Prevention (CDC) Etiology of Respiratory Infection Surveillance Study Team

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