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Evaluation of osteoarthritic features in peripheral joints by ultrasound imaging: a systematic review

Evaluation of osteoarthritic features in peripheral joints by ultrasound imaging: a systematic review
Evaluation of osteoarthritic features in peripheral joints by ultrasound imaging: a systematic review
Objective: to determine how structural and inflammatory osteoarthritis (OA) features in peripheral joints are assessed, defined and graded by ultrasound (US) imaging.

Design: MEDLINE, CINAHL, Cochrane and SPORTDiscus were systematically searched in March 2021. To be eligible, studies needed to (1) include participants with peripheral joint OA, and (2) used grey scale USI or power Doppler (PD) to assess one or more US features in peripheral joints of the hands and feet. Methodological quality of all included studies was assessed using the Critical Appraisal Skills Program (CASP) tool.

Results: a total of 159 citations were identified for screening. Thirty-two articles were included for final analysis and were of good methodological quality. Thirty articles evaluated US features of hand OA and two assessed US OA features in the foot. There were inconsistencies between studies in terms of what US features were assessed, how these features were defined and what grading system was applied to determine degree of osteoarthritic change.

Conclusion: the review found inconsistencies in the definition of synovial pathology. Consequently, it is unclear whether synovial pathology is best represented as separate entities or combined as a single domain, termed “synovitis”. How OA US features were defined and graded has largely been extrapolated from recommendations originally constructed for populations with rheumatoid arthritis (RA). Given the prognostic value of synovitis for OA progression and the reduced degree of inflammation experienced in OA compared to RA, the validity of applying definitions, grading systems and atlases originally developed for inflammatory arthritis needs consideration.
2665-9131
100194
Molyneux, Prue
aca46efc-cd44-4367-adec-7e457e0ad665
Bowen, Catherine
fd85c3c5-96d9-49b8-86c6-caa94e1a222b
Ellis, Richard
bf3e2ce1-2010-4487-81ed-e0c25be4fe17
Rome, Keith
fc9a40cd-cd38-4f5c-b42e-bcb4ef91dd12
Frecklington, Mike
6444ab7c-1345-4fb9-8247-16526c5cb5b7
Carroll, Matthew
3f70a4eb-4540-4e77-81e2-94ebfdece2a5
Molyneux, Prue
aca46efc-cd44-4367-adec-7e457e0ad665
Bowen, Catherine
fd85c3c5-96d9-49b8-86c6-caa94e1a222b
Ellis, Richard
bf3e2ce1-2010-4487-81ed-e0c25be4fe17
Rome, Keith
fc9a40cd-cd38-4f5c-b42e-bcb4ef91dd12
Frecklington, Mike
6444ab7c-1345-4fb9-8247-16526c5cb5b7
Carroll, Matthew
3f70a4eb-4540-4e77-81e2-94ebfdece2a5

Molyneux, Prue, Bowen, Catherine, Ellis, Richard, Rome, Keith, Frecklington, Mike and Carroll, Matthew (2021) Evaluation of osteoarthritic features in peripheral joints by ultrasound imaging: a systematic review. Osteoarthritis and Cartilage Open, 3 (3), 100194. (doi:10.1016/j.ocarto.2021.100194).

Record type: Article

Abstract

Objective: to determine how structural and inflammatory osteoarthritis (OA) features in peripheral joints are assessed, defined and graded by ultrasound (US) imaging.

Design: MEDLINE, CINAHL, Cochrane and SPORTDiscus were systematically searched in March 2021. To be eligible, studies needed to (1) include participants with peripheral joint OA, and (2) used grey scale USI or power Doppler (PD) to assess one or more US features in peripheral joints of the hands and feet. Methodological quality of all included studies was assessed using the Critical Appraisal Skills Program (CASP) tool.

Results: a total of 159 citations were identified for screening. Thirty-two articles were included for final analysis and were of good methodological quality. Thirty articles evaluated US features of hand OA and two assessed US OA features in the foot. There were inconsistencies between studies in terms of what US features were assessed, how these features were defined and what grading system was applied to determine degree of osteoarthritic change.

Conclusion: the review found inconsistencies in the definition of synovial pathology. Consequently, it is unclear whether synovial pathology is best represented as separate entities or combined as a single domain, termed “synovitis”. How OA US features were defined and graded has largely been extrapolated from recommendations originally constructed for populations with rheumatoid arthritis (RA). Given the prognostic value of synovitis for OA progression and the reduced degree of inflammation experienced in OA compared to RA, the validity of applying definitions, grading systems and atlases originally developed for inflammatory arthritis needs consideration.

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Accepted/In Press date: 13 July 2021
Published date: 1 September 2021

Identifiers

Local EPrints ID: 451243
URI: http://eprints.soton.ac.uk/id/eprint/451243
ISSN: 2665-9131
PURE UUID: 466bb928-1619-40c6-a417-f809104b2eff
ORCID for Catherine Bowen: ORCID iD orcid.org/0000-0002-7252-9515

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Date deposited: 14 Sep 2021 20:59
Last modified: 03 Nov 2021 02:38

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Contributors

Author: Prue Molyneux
Author: Catherine Bowen ORCID iD
Author: Richard Ellis
Author: Keith Rome
Author: Mike Frecklington
Author: Matthew Carroll

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