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The effect of caloric restriction with and without n-3 PUFA supplementation on bone turnover markers in blood of subjects with abdominal obesity: A randomized placebo-controlled trial

The effect of caloric restriction with and without n-3 PUFA supplementation on bone turnover markers in blood of subjects with abdominal obesity: A randomized placebo-controlled trial
The effect of caloric restriction with and without n-3 PUFA supplementation on bone turnover markers in blood of subjects with abdominal obesity: A randomized placebo-controlled trial

Weight loss contributes to an increased risk of hip fracture, especially in postmenopausal women. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation could diminish the adverse effect of weight loss on bone health. The aim of this randomized, placebo-controlled, double-blind parallel trial was to investigate the effect of caloric restriction and n-3 PUFA supplement intake on osteogenic markers (carboxylated osteocalcin (Gla-OC); procollagen I N-terminal propeptide (PINP)), as well as a bone resorption marker (C-terminal telopeptide of type I collagen (CTX-I)) in a serum of 64 middle aged individuals (BMI 25–40 kg/m2) with abdominal obesity. Bone remodeling, metabolic and inflammatory parameters and adipokines were determined before and after 3 months of an isocaloric diet (2300–2400 kcal/day) or a low-calorie diet (1200 kcal/day for women and 1500 kcal/day for men) along with n-3 PUFA (1.8 g/day) or placebo capsules. CTX-I and adiponectin concentrations were increased following 7% weight loss independently of supplement use. Changes in CTX-I were positively associated with changes in adiponectin level (rho = 0.25, p = 0.043). Thus, an increase in serum adiponectin caused by body weight loss could adversely affect bone health. N-3 PUFAs were without effect.
Bone turnover, Caloric restriction, N-3 PUFAs, Obesity
2072-6643
3096
Razny, Urszula
e00acde1-b8db-43ef-bd12-c971a468291a
Goralska, Joanna
8a418b46-c152-4248-916b-52bfe8c04b0b
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Gruca, Anna
cd3098ed-f19e-4fc6-9543-35e78032c029
Childs, Caroline
ea17ccc1-2eac-4f67-96c7-a0c4d9dfd9c5
Kapusta, Maria
92b46a3a-52b8-4df7-bda5-91a48b0143d7
Slowinska-Solnica, Krystyna
3846b45b-02de-47f7-9a86-1b21eaa69aeb
Dembinska-Kiec, Aldona
e14bab27-df5b-459e-b038-ef2c80cdf4fa
Solnica, Bogdan
c07951d8-ba3b-47e8-b056-f1631b50e882
Malczewska-Malec, Malgorzata
9ddf268e-d752-4c53-8b74-b7c192003e54
Razny, Urszula
e00acde1-b8db-43ef-bd12-c971a468291a
Goralska, Joanna
8a418b46-c152-4248-916b-52bfe8c04b0b
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Gruca, Anna
cd3098ed-f19e-4fc6-9543-35e78032c029
Childs, Caroline
ea17ccc1-2eac-4f67-96c7-a0c4d9dfd9c5
Kapusta, Maria
92b46a3a-52b8-4df7-bda5-91a48b0143d7
Slowinska-Solnica, Krystyna
3846b45b-02de-47f7-9a86-1b21eaa69aeb
Dembinska-Kiec, Aldona
e14bab27-df5b-459e-b038-ef2c80cdf4fa
Solnica, Bogdan
c07951d8-ba3b-47e8-b056-f1631b50e882
Malczewska-Malec, Malgorzata
9ddf268e-d752-4c53-8b74-b7c192003e54

Razny, Urszula, Goralska, Joanna, Calder, Philip, Gruca, Anna, Childs, Caroline, Kapusta, Maria, Slowinska-Solnica, Krystyna, Dembinska-Kiec, Aldona, Solnica, Bogdan and Malczewska-Malec, Malgorzata (2021) The effect of caloric restriction with and without n-3 PUFA supplementation on bone turnover markers in blood of subjects with abdominal obesity: A randomized placebo-controlled trial. Nutrients, 13 (9), 3096, [3096]. (doi:10.3390/nu13093096).

Record type: Article

Abstract


Weight loss contributes to an increased risk of hip fracture, especially in postmenopausal women. Omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation could diminish the adverse effect of weight loss on bone health. The aim of this randomized, placebo-controlled, double-blind parallel trial was to investigate the effect of caloric restriction and n-3 PUFA supplement intake on osteogenic markers (carboxylated osteocalcin (Gla-OC); procollagen I N-terminal propeptide (PINP)), as well as a bone resorption marker (C-terminal telopeptide of type I collagen (CTX-I)) in a serum of 64 middle aged individuals (BMI 25–40 kg/m2) with abdominal obesity. Bone remodeling, metabolic and inflammatory parameters and adipokines were determined before and after 3 months of an isocaloric diet (2300–2400 kcal/day) or a low-calorie diet (1200 kcal/day for women and 1500 kcal/day for men) along with n-3 PUFA (1.8 g/day) or placebo capsules. CTX-I and adiponectin concentrations were increased following 7% weight loss independently of supplement use. Changes in CTX-I were positively associated with changes in adiponectin level (rho = 0.25, p = 0.043). Thus, an increase in serum adiponectin caused by body weight loss could adversely affect bone health. N-3 PUFAs were without effect.

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Accepted/In Press date: 30 August 2021
e-pub ahead of print date: 2 September 2021
Keywords: Bone turnover, Caloric restriction, N-3 PUFAs, Obesity

Identifiers

Local EPrints ID: 451293
URI: http://eprints.soton.ac.uk/id/eprint/451293
ISSN: 2072-6643
PURE UUID: 3a36597c-6ebf-4be7-af4f-17b1ffcc0d34
ORCID for Philip Calder: ORCID iD orcid.org/0000-0002-6038-710X
ORCID for Caroline Childs: ORCID iD orcid.org/0000-0001-6832-224X

Catalogue record

Date deposited: 17 Sep 2021 16:30
Last modified: 08 Oct 2021 01:41

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Contributors

Author: Urszula Razny
Author: Joanna Goralska
Author: Philip Calder ORCID iD
Author: Anna Gruca
Author: Caroline Childs ORCID iD
Author: Maria Kapusta
Author: Krystyna Slowinska-Solnica
Author: Aldona Dembinska-Kiec
Author: Bogdan Solnica
Author: Malgorzata Malczewska-Malec

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