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Respiratory outcomes in patients following COVID-19-related hospitalisation: a meta-analysis

Respiratory outcomes in patients following COVID-19-related hospitalisation: a meta-analysis
Respiratory outcomes in patients following COVID-19-related hospitalisation: a meta-analysis
Background: to determine the respiratory outcomes in patients following COVID-19-related hospitalisation. Methods: Systematic review and meta-analysis of the literature. Results: forced vital capacity (FVC, % of predicted): 0-3 months post discharge: 94.9,95% CI [82.2-107.7]; 3-6 months post discharge: 99.9, 95% CI [84.8, 115.0]; > 6 months post discharge: 97.4, 95% CI [76.8-118.0]. Diffusing capacity of the lungs for carbon monoxide (DLCO, % of predicted): 0-3 months post discharge: 83.9, 95% CI [68.9-98.9]; 3-6 months post discharge: 91.2, 95% CI [74.8-107.7]; > 6 months post discharge: 97.3, 95% CI [76.7-117.9]. Percentage of patients with FVC less than 80% of predicted: 0-3 months post discharge: 10%, 95% CI [6-14%]; 3-6 months post discharge: 10%, 95% CI [2-18%]; > 6 months post discharge: 13%, 95% CI [8-18%]. Percentage of patients with DLCO less than 80% of predicted: 0-3 months post discharge: 48%, 95% CI [41-56%]; 3-6 months post discharge: 33%, 95% CI [23- 44%]; > 6 months post discharge: 43%, 95% CI [22-65%]. Conclusion: the meta analysis confirms a high prevalence of persistent lung diffusion impairment in patients following COVID-19-related hospitalisation. Routine respiratory follow-up is thus strongly recommended.
2296-889X
Guo, Tao
9c796deb-4ee0-4fc8-9f76-e0cffcb842ab
Jiang, Fangfang
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Liu, Yufei
8359cf9a-e997-48d0-a2e6-402e6fe1c546
Zhao, Yunpeng
94be821a-fbe9-48e3-816d-5da206c2a646
Li, Yiran
e863b1e2-cf23-4cb2-8fd2-4e00c44cf1d4
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e
Guo, Tao
9c796deb-4ee0-4fc8-9f76-e0cffcb842ab
Jiang, Fangfang
26509fd0-b25c-4817-86df-075018f82444
Liu, Yufei
8359cf9a-e997-48d0-a2e6-402e6fe1c546
Zhao, Yunpeng
94be821a-fbe9-48e3-816d-5da206c2a646
Li, Yiran
e863b1e2-cf23-4cb2-8fd2-4e00c44cf1d4
Wang, Yihua
f5044a95-60a7-42d2-87d6-5f1f789e3a7e

Guo, Tao, Jiang, Fangfang, Liu, Yufei, Zhao, Yunpeng, Li, Yiran and Wang, Yihua (2021) Respiratory outcomes in patients following COVID-19-related hospitalisation: a meta-analysis. Frontiers in Molecular Biosciences. (In Press)

Record type: Article

Abstract

Background: to determine the respiratory outcomes in patients following COVID-19-related hospitalisation. Methods: Systematic review and meta-analysis of the literature. Results: forced vital capacity (FVC, % of predicted): 0-3 months post discharge: 94.9,95% CI [82.2-107.7]; 3-6 months post discharge: 99.9, 95% CI [84.8, 115.0]; > 6 months post discharge: 97.4, 95% CI [76.8-118.0]. Diffusing capacity of the lungs for carbon monoxide (DLCO, % of predicted): 0-3 months post discharge: 83.9, 95% CI [68.9-98.9]; 3-6 months post discharge: 91.2, 95% CI [74.8-107.7]; > 6 months post discharge: 97.3, 95% CI [76.7-117.9]. Percentage of patients with FVC less than 80% of predicted: 0-3 months post discharge: 10%, 95% CI [6-14%]; 3-6 months post discharge: 10%, 95% CI [2-18%]; > 6 months post discharge: 13%, 95% CI [8-18%]. Percentage of patients with DLCO less than 80% of predicted: 0-3 months post discharge: 48%, 95% CI [41-56%]; 3-6 months post discharge: 33%, 95% CI [23- 44%]; > 6 months post discharge: 43%, 95% CI [22-65%]. Conclusion: the meta analysis confirms a high prevalence of persistent lung diffusion impairment in patients following COVID-19-related hospitalisation. Routine respiratory follow-up is thus strongly recommended.

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Meta_COVID lung function follow-up_final_R3 - Accepted Manuscript
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Accepted/In Press date: 7 September 2021

Identifiers

Local EPrints ID: 451331
URI: http://eprints.soton.ac.uk/id/eprint/451331
ISSN: 2296-889X
PURE UUID: 53aa4e84-ead8-4d22-a94f-4c8d35e52704
ORCID for Yihua Wang: ORCID iD orcid.org/0000-0001-5561-0648

Catalogue record

Date deposited: 21 Sep 2021 16:31
Last modified: 07 Oct 2021 04:01

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Contributors

Author: Tao Guo
Author: Fangfang Jiang
Author: Yufei Liu
Author: Yunpeng Zhao
Author: Yiran Li
Author: Yihua Wang ORCID iD

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