Weak molecular interactions in clathrin-mediated endocytosis
Weak molecular interactions in clathrin-mediated endocytosis
Clathrin-mediated endocytosis is a process by which specific molecules are internalized from the cell periphery for delivery to early endosomes. The key stages in this step-wise process, from the starting point of cargo recognition, to the later stage of assembly of the clathrin coat, are dependent on weak interactions between a large network of proteins. This review discusses the structural and functional data that have improved our knowledge and understanding of the main weak molecular interactions implicated in clathrin-mediated endocytosis, with a particular focus on the two key proteins: AP2 and clathrin.
Clathrin, endocytosis, adaptor-protein, Structural biology, Molecular interactions
72
Smith, Sarah
e275e44e-b6a9-4499-b44b-77a726d7f94f
Baker, Michael
dcfe236e-a8ab-49b7-b596-fc9bd65e3969
Halebian, Mary
b323cf8e-a709-471b-87ab-19939d77de94
Smith, Corinne
7be8ae44-6cd5-49fb-ad8b-d51e186914b4
14 November 2017
Smith, Sarah
e275e44e-b6a9-4499-b44b-77a726d7f94f
Baker, Michael
dcfe236e-a8ab-49b7-b596-fc9bd65e3969
Halebian, Mary
b323cf8e-a709-471b-87ab-19939d77de94
Smith, Corinne
7be8ae44-6cd5-49fb-ad8b-d51e186914b4
Smith, Sarah, Baker, Michael, Halebian, Mary and Smith, Corinne
(2017)
Weak molecular interactions in clathrin-mediated endocytosis.
Frontiers in Molecular Biosciences, 4, .
(doi:10.3389/fmolb.2017.00072).
Abstract
Clathrin-mediated endocytosis is a process by which specific molecules are internalized from the cell periphery for delivery to early endosomes. The key stages in this step-wise process, from the starting point of cargo recognition, to the later stage of assembly of the clathrin coat, are dependent on weak interactions between a large network of proteins. This review discusses the structural and functional data that have improved our knowledge and understanding of the main weak molecular interactions implicated in clathrin-mediated endocytosis, with a particular focus on the two key proteins: AP2 and clathrin.
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Published date: 14 November 2017
Keywords:
Clathrin, endocytosis, adaptor-protein, Structural biology, Molecular interactions
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Local EPrints ID: 451706
URI: http://eprints.soton.ac.uk/id/eprint/451706
ISSN: 2296-889X
PURE UUID: d5210f0b-0f0d-4c06-b14e-ba7a3309ff94
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Date deposited: 21 Oct 2021 16:30
Last modified: 16 Mar 2024 13:45
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Author:
Sarah Smith
Author:
Mary Halebian
Author:
Corinne Smith
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