Synergies between hyperpolarized NMR and microfluidics: a review
Synergies between hyperpolarized NMR and microfluidics: a review
Hyperpolarized nuclear magnetic resonance and lab-on-a-chip microfluidics are two dynamic, but until recently quite distinct, fields of research. Recent developments in both areas increased their synergistic overlap. By microfluidic integration, many complex experimental steps can be brought together onto a single platform. Microfluidic devices are therefore increasingly finding applications in medical diagnostics, forensic analysis, and biomedical research. In particular, they provide novel and powerful ways to culture cells, cell aggregates, and even functional models of entire organs. Nuclear magnetic resonance is a non-invasive, high-resolution spectroscopic technique which allows real-time process monitoring with chemical specificity. It is ideally suited for observing metabolic and other biological and chemical processes in microfluidic systems. However, its intrinsically low sensitivity has limited its application. Recent advances in nuclear hyperpolarization techniques may change this: under special circumstances, it is possible to enhance NMR signals by up to 5 orders of magnitude, which dramatically extends the utility of NMR in the context of microfluidic systems. At the same time, hyperpolarization requires complex chemical and/or physical manipulations, which in turn may benefit from microfluidic implementation. In fact, many hyperpolarization methodologies rely on processes that are more efficient at the micro-scale, such as molecular diffusion, penetration electromagnetic radiation into the sample, or restricted molecular mobility on a surface. In this review we examine the confluence between the fields of hyperpolarization-enhanced NMR and microfluidics, and assess how these areas of research have mutually benefited one another, and will continue to do so.
Hyperpolarization, Lab-on-a-chip, Microfluidics, NMR
Eills, James
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Hale, William G
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Utz, Marcel
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Eills, James
23130b21-68fa-4c8b-9399-e55f2e71ef36
Hale, William G
d98f9d64-00f9-447e-9783-185185a0b3c6
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Eills, James, Hale, William G and Utz, Marcel
(2021)
Synergies between hyperpolarized NMR and microfluidics: a review.
Progress in Nuclear Magnetic Resonance Spectroscopy.
(doi:10.1016/j.pnmrs.2021.09.001).
Abstract
Hyperpolarized nuclear magnetic resonance and lab-on-a-chip microfluidics are two dynamic, but until recently quite distinct, fields of research. Recent developments in both areas increased their synergistic overlap. By microfluidic integration, many complex experimental steps can be brought together onto a single platform. Microfluidic devices are therefore increasingly finding applications in medical diagnostics, forensic analysis, and biomedical research. In particular, they provide novel and powerful ways to culture cells, cell aggregates, and even functional models of entire organs. Nuclear magnetic resonance is a non-invasive, high-resolution spectroscopic technique which allows real-time process monitoring with chemical specificity. It is ideally suited for observing metabolic and other biological and chemical processes in microfluidic systems. However, its intrinsically low sensitivity has limited its application. Recent advances in nuclear hyperpolarization techniques may change this: under special circumstances, it is possible to enhance NMR signals by up to 5 orders of magnitude, which dramatically extends the utility of NMR in the context of microfluidic systems. At the same time, hyperpolarization requires complex chemical and/or physical manipulations, which in turn may benefit from microfluidic implementation. In fact, many hyperpolarization methodologies rely on processes that are more efficient at the micro-scale, such as molecular diffusion, penetration electromagnetic radiation into the sample, or restricted molecular mobility on a surface. In this review we examine the confluence between the fields of hyperpolarization-enhanced NMR and microfluidics, and assess how these areas of research have mutually benefited one another, and will continue to do so.
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More information
Accepted/In Press date: 11 September 2021
e-pub ahead of print date: 30 September 2021
Additional Information:
Funding Information:
J.E. would like to acknowledge funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 766402. M.U. gratefully acknowledges support from the EU H2020 FETOPEN project ”TISuMR” (Grant Agreement No. 737043). The authors thank Dr. Giorgos Chatzidrosos and Dr. Kirill Sheberstov for helpful comments on the manuscript, and J.E. would like to thank Prof. Igor Koptyug and Prof. Dmitry Budker for stimulating discussions about hyperpolarization-enhanced NMR and catalysis. W.H. thanks Prof. Russ Bowers for helpful discussions and mentorship.
Funding Information:
J.E. would like to acknowledge funding from the European Union's Horizon 2020 research and innovation programme under the Marie Sk?odowska-Curie Grant Agreement No. 766402. M.U. gratefully acknowledges support from the EU H2020 FETOPEN project ?TISuMR? (Grant Agreement No. 737043). The authors thank Dr. Giorgos Chatzidrosos and Dr. Kirill Sheberstov for helpful comments on the manuscript, and J.E. would like to thank Prof. Igor Koptyug and Prof. Dmitry Budker for stimulating discussions about hyperpolarization-enhanced NMR and catalysis. W.H. thanks Prof. Russ Bowers for helpful discussions and mentorship.
Publisher Copyright:
© 2021 Elsevier B.V.
Keywords:
Hyperpolarization, Lab-on-a-chip, Microfluidics, NMR
Identifiers
Local EPrints ID: 452036
URI: http://eprints.soton.ac.uk/id/eprint/452036
PURE UUID: 9f08c480-92a8-4427-b107-9d04d61ab0fa
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Date deposited: 09 Nov 2021 17:32
Last modified: 17 Mar 2024 06:54
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Author:
James Eills
Author:
William G Hale
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