A prenylated dsRNA sensor protects against severe COVID-19

Accepted/In Press date: 23 September 2021

e-pub ahead of print date: 28 September 2021

Published date: 29 October 2021

Additional Information: Funding Information: Thi work was partly funded by UKRI/NIHR through the UK Coronavirus Immunology Consortium (UK-CIC MR/V028448/1 to M.P. and S.J.W.) and the MRC through the following grants: MR/K024752/1 (to S.J.W.), MC_UU_12014/10 (to M.P. and S.J.W.), MC_UU_12014/12 (to J.H., D.L.R., and S.K.) and MR/P022642/1 (to S.J.W. and S.J.R.), MR/V000489/1 (to E.C.Y.W. and R.J.S.), MR/S00971X/1 (to R.J.S. and E.C.Y.W.), MR/P001602/1 (to E.C.Y.W.), and MR/V011561/1 (to P.J.L.). Support was also provided by a Wellcome Principal Research Fellowship 210688/Z/18/Z (to P.J.L.), a Wellcome Trust Fellowship 201366/Z/16/Z (to S.J.R.), a Wellcome Investigator Award 209412/Z/17/Z (to I.D.), the Addenbrooke's Charitable Trust and the NIHR Cambridge Biomedical Research Centre (to P.J.L.), support from the German Research Foundation, Deutsche Forschungsgemeinschaft; project number 406109949 (to V.H.), and German Federal Ministry of Food and Agriculture through BMEL F?rderkennzeichen: 01KI1723G (to V.H.), and a Daphne Jackson Fellowship funded by Medical Research Scotland (to S.S.). A.C. is supported by MRC grants MR/R021562/1, MC_UU_12014/10, and MC_UU_12014/12. J.Y.L. is funded by a Medial Sciences Graduate Studentship, University of Oxford. L.I. is funded by BBSRC DTP scholarship number BB/M011224/1. MAIC analysis was supported by the SHIELD Consortium (MRC grant MRNO2995X/1). ISARIC4C is supported by grants from the Medical Research Council (grant MC_PC_19059), the NIHR (award CO-CIN-01) and by the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at University of Liverpool in partnership with Public Health England (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford (award 200907), NIHR HPRU in Respiratory Infections at Imperial College London with PHE (award 200927), Wellcome Trust and Department for International Development (215091/Z/18/Z), and the Bill and Melinda Gates Foundation (OPP1209135), and Liverpool Experimental Cancer Medicine Centre (C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (IS-BRC-1215-20013), EU Platform foR European Preparedness Against (Re-)emerging Epidemics (PREPARE) (FP7 project 602525) and NIHR Clinical Research Network provided infrastructure support for this research. Publisher Copyright: Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

Local EPrints ID: 452070

URI: http://eprints.soton.ac.uk/id/eprint/452070

DOI: doi:10.1126/science.abj3624

ISSN: 0036-8075

PURE UUID: f2970682-bcfb-4389-9669-05af0eebf7b3

ORCID for Ahilanandan Dushianthan: orcid.org/0000-0002-0165-3359

Date deposited: 10 Nov 2021 17:36

Last modified: 16 Apr 2024 01:54