Miao, Lei, Yang, Li, Guo, Li-Sha, Shi, Qiang-Qiang, Zhou, Teng-Fei, Chen, Yang, Zhang, Huai, Cai, Hui, Xu, Zhi-Wei, Yang, Shuan-Ying, Lin, Hai, Cheng, Zhe, Zhu, Ming-Yang, Nan, Xu, Huang, Shuai, Zheng, Ya-Wen, Targher, Giovanni, Byrne, Christopher, Li, Yu-Ping, Zheng, Ming-Hua and Chen, Cheng-Shui (2022) Metabolic dysfunction-associated fatty liver disease is associated with greater impairment of lung function than nonalcoholic fatty liver disease. Journal of Clinical and Translational Hepatology, 10 (2), 230-237. (doi:10.14218/JCTH.2021.00306).
Abstract
Background and Aims: We compared lung function parameters in nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD), and examined the association between lung function parameters and fibrosis severity in MAFLD. Meth-ods: In this cross-sectional study, we randomly recruited 2,543 middle-aged individuals from 25 communities across four cities in China during 2016 and 2020. All participants received a health check-up including measurement of anthropometric parameters, biochemical variables, liver ultrasonography, and spirometry. The severity of liver disease was assessed by the fibrosis (FIB)-4 score. Results: The prevalence of MAFLD was 20.4% (n=519) and that of NAFLD was 18.4% (n=469). After adjusting for age, sex, adiposity measures, smoking status, and significant alcohol intake, subjects with MAFLD had a significantly lower predicted forced vital capacity (FVC, 88.27±17.60% vs. 90.82±16.85%, p<0.05) and lower 1 s forced expiratory volume (FEV 1, 79.89±17.34 vs. 83.02±16.66%, p<0.05) than those with NAFLD. MAFLD with an increased FIB-4 score was significantly associated with decreased lung function. For each 1-point increase in FIB-4, FVC was diminished by 0.507 (95% CI: −0.840, −0.173, p=0.003), and FEV 1 was diminished by 0.439 (95% CI: −0.739, −0.140, p=0.004). The results remained unchanged when the statistical analyses was performed separately for men and women. Conclusions: MAFLD was significantly associated with a greater impairment of lung function parameters than NAFLD.
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