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Systematic reviews and quality appraisal of In vitro cancer studies: Investigation of current practice

Systematic reviews and quality appraisal of In vitro cancer studies: Investigation of current practice
Systematic reviews and quality appraisal of In vitro cancer studies: Investigation of current practice
Background/Aim: To assess the quantity and quality of systematic reviews of in vitro cancer studies. Materials and Methods: PubMed, MEDLINE, Embase, Web of Knowledge and PROSPERO databases were searched. Articles described as systematic reviews of in vitro studies, focused on or relevant to cancer and published in English were selected and appraised using an adapted version of AMSTAR 2 ‘critical domains’. Results: From 4,021 records, 41 reviews described as systematic and cancer-related were identified. Publication dates indicate increasing frequency of systematic review conduct. Mean number of databases searched was three (range=1-8). Thirty-six reviews (88%) reported search methods, 35 (85%) specified inclusion criteria, 26 (63%) reported study selection methods, and 21 (51%) used reporting guidelines. Only 13 reviews (32%) involved formal quality assessment. Conclusion: Detailed investigation of reviews of cancer-relevant in vitro studies indicates need for further development and use of robust search strategies, appropriate quality assessment tools, and researchers with relevant skills.
Cell culture, Critical appraisal, In vitro studies, In vitro techniques, Neoplasms, Quality, Review, Systematic reviews
0250-7005
5377-5391
Bracher, Michael
e9e2fbd6-af5f-4f6e-8357-969aaf51c52e
Pilkington, Geoffrey J.
c61b55d2-41d3-46e9-96ee-48a82e1abb0d
Pilkington, Karen
2abedd15-16bf-45df-a21c-82820fea5743
Bracher, Michael
e9e2fbd6-af5f-4f6e-8357-969aaf51c52e
Pilkington, Geoffrey J.
c61b55d2-41d3-46e9-96ee-48a82e1abb0d
Pilkington, Karen
2abedd15-16bf-45df-a21c-82820fea5743

Bracher, Michael, Pilkington, Geoffrey J. and Pilkington, Karen (2021) Systematic reviews and quality appraisal of In vitro cancer studies: Investigation of current practice. Anticancer research, 41 (11), 5377-5391. (doi:10.21873/anticanres.15350).

Record type: Review

Abstract

Background/Aim: To assess the quantity and quality of systematic reviews of in vitro cancer studies. Materials and Methods: PubMed, MEDLINE, Embase, Web of Knowledge and PROSPERO databases were searched. Articles described as systematic reviews of in vitro studies, focused on or relevant to cancer and published in English were selected and appraised using an adapted version of AMSTAR 2 ‘critical domains’. Results: From 4,021 records, 41 reviews described as systematic and cancer-related were identified. Publication dates indicate increasing frequency of systematic review conduct. Mean number of databases searched was three (range=1-8). Thirty-six reviews (88%) reported search methods, 35 (85%) specified inclusion criteria, 26 (63%) reported study selection methods, and 21 (51%) used reporting guidelines. Only 13 reviews (32%) involved formal quality assessment. Conclusion: Detailed investigation of reviews of cancer-relevant in vitro studies indicates need for further development and use of robust search strategies, appropriate quality assessment tools, and researchers with relevant skills.

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More information

Accepted/In Press date: 28 September 2021
Published date: 3 November 2021
Keywords: Cell culture, Critical appraisal, In vitro studies, In vitro techniques, Neoplasms, Quality, Review, Systematic reviews

Identifiers

Local EPrints ID: 452250
URI: http://eprints.soton.ac.uk/id/eprint/452250
ISSN: 0250-7005
PURE UUID: 5e952ec9-8de9-4b03-b28b-dc93b20bada9
ORCID for Michael Bracher: ORCID iD orcid.org/0000-0001-5861-2657

Catalogue record

Date deposited: 02 Dec 2021 17:30
Last modified: 10 Jan 2022 02:56

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Contributors

Author: Michael Bracher ORCID iD
Author: Geoffrey J. Pilkington
Author: Karen Pilkington

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