Residential greenness-related DNA methylation changes

Background: Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective: To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods: We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results: We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions: Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.

Allergy, Allostatic load, DNA methylation, EWAS, Enrichment test, Greenness, Pathway analysis, Physical activity

10.1016/j.envint.2021.106945

0160-4120

106945

Jeong, Ayoung

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Eze, Ikenna C.

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Vienneau, Danielle

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De Hoogh, Kees

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Keidel, Dirk

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Rothe, Thomas

ff5fdd32-ad79-4a03-9ee3-c08077ab6e88

Burdet, Luc

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Holloway, John W.

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Jarvis, Debbie

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Kronenberg, Florian

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Lovison, Gianfranco

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Imboden, Medea

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Probst-hensch, Nicole

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1 January 2022

Jeong, Ayoung

d742adca-f0fd-4da7-89ba-a01b5e879664

Eze, Ikenna C.

e29f8a9c-8206-478a-b12c-23c8d28df77b

Vienneau, Danielle

a56c1424-c49c-49d0-a898-69c94b28eab8

De Hoogh, Kees

99d4e192-0f40-4303-ab22-66de4ae9ac32

Keidel, Dirk

f9d8c5c7-722a-406e-9a00-246267c05ec4

Rothe, Thomas

ff5fdd32-ad79-4a03-9ee3-c08077ab6e88

Burdet, Luc

0e199467-709e-44e4-94a4-126adaf9bf55

Holloway, John W.

4bbd77e6-c095-445d-a36b-a50a72f6fe1a

Jarvis, Debbie

f4d96433-2732-4463-b7a7-e52a88950d29

Kronenberg, Florian

056e8fa9-c2f1-4d61-a849-19ad35ed5c34

Lovison, Gianfranco

0a75d72a-64f6-425b-a5ab-971f2cec6fbe

Imboden, Medea

7ac4495d-e803-4e18-b6ba-318da568f776

Probst-hensch, Nicole

33ee3cca-a1d4-4157-87c3-20ebfd84406f

Jeong, Ayoung, Eze, Ikenna C., Vienneau, Danielle, De Hoogh, Kees, Keidel, Dirk, Rothe, Thomas, Burdet, Luc, Holloway, John W., Jarvis, Debbie, Kronenberg, Florian, Lovison, Gianfranco, Imboden, Medea and Probst-hensch, Nicole (2022) Residential greenness-related DNA methylation changes. Environment International, 158, 106945, [106945]. (doi:10.1016/j.envint.2021.106945).

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Accepted/In Press date: 18 October 2021

e-pub ahead of print date: 21 October 2021

Published date: 1 January 2022

Additional Information: Funding Information: This work was supported by the European Union's Horizon 2020 Research and Innovation programme under grant agreement no. 633212 (ALEC Study). SAPALDIA has been supported since its onset by the Swiss National Science Foundation (SNF grants 33CS30-177506/1, 33CS30-148470/2, 33CS30-148470/1, 33CSCO-134276/1, 33CSCO-108796, 324730_135673, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099, PMPDP3_129021/1, PMPDP3_141671/1); the Swiss Federal Office for the Environment; the Federal Office of Public Health; the Federal Office of Roads and Transport; the canton's government of Aargau, Basel-Stadt, Basel-Land, Geneva, Luzern, Ticino, Valais, and Z?rich; the Swiss Lung League; the canton's Lung League of Basel Stadt/Basel Landschaft, Geneva, Ticino, Valais, Graub?nden and Zurich; Stiftung ehemals B?ndner Heilst?tten; SUVA; Freiwillige Akademische Gesellschaft; UBS Wealth Foundation; European Commission (grant agreement no. 018996 (GABRIEL); Wellcome Trust (grant agreement WT 084703MA). Funding Information: This work was supported by the European Union’s Horizon 2020 Research and Innovation programme under grant agreement no. 633212 (ALEC Study). SAPALDIA has been supported since its onset by the Swiss National Science Foundation (SNF grants 33CS30-177506/1 , 33CS30-148470/2 , 33CS30-148470/1 , 33CSCO-134276/1 , 33CSCO-108796 , 324730_135673 , 3247BO-104283 , 3247BO-104288 , 3247BO-104284 , 3247-065896 , 3100-059302 , 3200-052720 , 3200-042532 , 4026-028099 , PMPDP3_129021/1 , PMPDP3_141671/1 ); the Swiss Federal Office for the Environment; the Federal Office of Public Health; the Federal Office of Roads and Transport; the canton's government of Aargau, Basel-Stadt, Basel-Land, Geneva, Luzern, Ticino, Valais, and Zürich; the Swiss Lung League; the canton's Lung League of Basel Stadt/Basel Landschaft, Geneva, Ticino, Valais, Graubünden and Zurich; Stiftung ehemals Bündner Heilstätten; SUVA; Freiwillige Akademische Gesellschaft; UBS Wealth Foundation; European Commission (grant agreement no. 018996 (GABRIEL); Wellcome Trust (grant agreement WT 084703MA). Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

Keywords: Allergy, Allostatic load, DNA methylation, EWAS, Enrichment test, Greenness, Pathway analysis, Physical activity

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