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Residential greenness-related DNA methylation changes

Residential greenness-related DNA methylation changes
Residential greenness-related DNA methylation changes

Background: Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective: To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods: We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results: We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions: Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.

Allergy, Allostatic load, DNA methylation, EWAS, Enrichment test, Greenness, Pathway analysis, Physical activity
0160-4120
106945
Jeong, Ayoung
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Eze, Ikenna C.
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Vienneau, Danielle
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De Hoogh, Kees
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Keidel, Dirk
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Rothe, Thomas
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Burdet, Luc
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Holloway, John W.
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Jarvis, Debbie
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Kronenberg, Florian
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Lovison, Gianfranco
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Imboden, Medea
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Probst-hensch, Nicole
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Jeong, Ayoung
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Eze, Ikenna C.
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Vienneau, Danielle
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De Hoogh, Kees
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Keidel, Dirk
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Rothe, Thomas
ff5fdd32-ad79-4a03-9ee3-c08077ab6e88
Burdet, Luc
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Holloway, John W.
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Jarvis, Debbie
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Kronenberg, Florian
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Lovison, Gianfranco
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Imboden, Medea
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Probst-hensch, Nicole
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Jeong, Ayoung, Eze, Ikenna C., Vienneau, Danielle, De Hoogh, Kees, Keidel, Dirk, Rothe, Thomas, Burdet, Luc, Holloway, John W., Jarvis, Debbie, Kronenberg, Florian, Lovison, Gianfranco, Imboden, Medea and Probst-hensch, Nicole (2022) Residential greenness-related DNA methylation changes. Environment International, 158, 106945, [106945]. (doi:10.1016/j.envint.2021.106945).

Record type: Article

Abstract

Background: Residential greenness has been associated with health benefits, but its biological mechanism is largely unknown. Investigation of greenness-related DNA methylation profiles can contribute to mechanistic understanding of the health benefits of residential greenness. Objective: To identify DNA methylation profiles associated with greenness in the immediate surroundings of the residence. Methods: We analyzed genome-wide DNA methylation in 1938 blood samples (982 participants) from the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). We estimated residential greenness based on normalized difference vegetation index at 30 × 30 m cell (green30) and 500 m buffer (green500) around the residential address. We conducted epigenome-wide association study (EWAS) to identify differentially methylated CpGs and regions, and enrichment tests by comparing to the CpGs that previous EWAS identified as associated with allergy, physical activity, and allostatic load-relevant biomarkers. Results: We identified no genome-wide significant CpGs, but 163 and 56 differentially methylated regions for green30 and green500, respectively. Green30-related DNA methylation profiles showed enrichments in allergy, physical activity, and allostatic load, while green500-related methylation was enriched in allergy and allostatic load. Conclusions: Residential greenness may have health impacts through allergic sensitization, stress coping, or behavioral changes. Exposure to more proximal greenness may be more health-relevant.

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Accepted/In Press date: 18 October 2021
e-pub ahead of print date: 21 October 2021
Published date: 1 January 2022
Additional Information: Funding Information: This work was supported by the European Union's Horizon 2020 Research and Innovation programme under grant agreement no. 633212 (ALEC Study). SAPALDIA has been supported since its onset by the Swiss National Science Foundation (SNF grants 33CS30-177506/1, 33CS30-148470/2, 33CS30-148470/1, 33CSCO-134276/1, 33CSCO-108796, 324730_135673, 3247BO-104283, 3247BO-104288, 3247BO-104284, 3247-065896, 3100-059302, 3200-052720, 3200-042532, 4026-028099, PMPDP3_129021/1, PMPDP3_141671/1); the Swiss Federal Office for the Environment; the Federal Office of Public Health; the Federal Office of Roads and Transport; the canton's government of Aargau, Basel-Stadt, Basel-Land, Geneva, Luzern, Ticino, Valais, and Z?rich; the Swiss Lung League; the canton's Lung League of Basel Stadt/Basel Landschaft, Geneva, Ticino, Valais, Graub?nden and Zurich; Stiftung ehemals B?ndner Heilst?tten; SUVA; Freiwillige Akademische Gesellschaft; UBS Wealth Foundation; European Commission (grant agreement no. 018996 (GABRIEL); Wellcome Trust (grant agreement WT 084703MA). Funding Information: This work was supported by the European Union’s Horizon 2020 Research and Innovation programme under grant agreement no. 633212 (ALEC Study). SAPALDIA has been supported since its onset by the Swiss National Science Foundation (SNF grants 33CS30-177506/1 , 33CS30-148470/2 , 33CS30-148470/1 , 33CSCO-134276/1 , 33CSCO-108796 , 324730_135673 , 3247BO-104283 , 3247BO-104288 , 3247BO-104284 , 3247-065896 , 3100-059302 , 3200-052720 , 3200-042532 , 4026-028099 , PMPDP3_129021/1 , PMPDP3_141671/1 ); the Swiss Federal Office for the Environment; the Federal Office of Public Health; the Federal Office of Roads and Transport; the canton's government of Aargau, Basel-Stadt, Basel-Land, Geneva, Luzern, Ticino, Valais, and Zürich; the Swiss Lung League; the canton's Lung League of Basel Stadt/Basel Landschaft, Geneva, Ticino, Valais, Graubünden and Zurich; Stiftung ehemals Bündner Heilstätten; SUVA; Freiwillige Akademische Gesellschaft; UBS Wealth Foundation; European Commission (grant agreement no. 018996 (GABRIEL); Wellcome Trust (grant agreement WT 084703MA). Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
Keywords: Allergy, Allostatic load, DNA methylation, EWAS, Enrichment test, Greenness, Pathway analysis, Physical activity

Identifiers

Local EPrints ID: 452536
URI: http://eprints.soton.ac.uk/id/eprint/452536
ISSN: 0160-4120
PURE UUID: 64c00b75-a6f1-454f-82c9-38a67530bac8
ORCID for John W. Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 11 Dec 2021 11:26
Last modified: 17 Mar 2024 02:45

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Contributors

Author: Ayoung Jeong
Author: Ikenna C. Eze
Author: Danielle Vienneau
Author: Kees De Hoogh
Author: Dirk Keidel
Author: Thomas Rothe
Author: Luc Burdet
Author: Debbie Jarvis
Author: Florian Kronenberg
Author: Gianfranco Lovison
Author: Medea Imboden
Author: Nicole Probst-hensch

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