Long-term bisphosphonate therapy and atypical femoral fracture: can you have too much of a good thing?
Long-term bisphosphonate therapy and atypical femoral fracture: can you have too much of a good thing?
The long-term, continuous use of bisphosphonates (beyond 5 years) is not wholly without risk. Atypical femoral fracture is an uncommon but potentially very serious adverse event associated with the long-term use of bisphosphonates. Here we consider the complexities of long-term bisphosphonate prescribing, particularly in those that are low risk of osteoporotic fracture, wherein the duration of therapy should be reviewed regularly with individualised risk assessment to ensure the duration of treatment is appropriate.
bisphosphonate, deprescribing, medicines optimisation, osteoporosis
4877-4879
Walker, Lauren E
7a708443-8724-414e-8b52-9c7d65bf1443
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
December 2021
Walker, Lauren E
7a708443-8724-414e-8b52-9c7d65bf1443
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Walker, Lauren E and Cooper, Cyrus
(2021)
Long-term bisphosphonate therapy and atypical femoral fracture: can you have too much of a good thing?
British Journal of Clinical Pharmacology, 87 (12), .
(doi:10.1111/bcp.15110).
Abstract
The long-term, continuous use of bisphosphonates (beyond 5 years) is not wholly without risk. Atypical femoral fracture is an uncommon but potentially very serious adverse event associated with the long-term use of bisphosphonates. Here we consider the complexities of long-term bisphosphonate prescribing, particularly in those that are low risk of osteoporotic fracture, wherein the duration of therapy should be reviewed regularly with individualised risk assessment to ensure the duration of treatment is appropriate.
Text
Walker Long-term bisposphonate therapy BJCP
- Accepted Manuscript
More information
Accepted/In Press date: 1 October 2021
e-pub ahead of print date: 22 October 2021
Published date: December 2021
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Publisher Copyright:
© 2021 British Pharmacological Society
Keywords:
bisphosphonate, deprescribing, medicines optimisation, osteoporosis
Identifiers
Local EPrints ID: 452566
URI: http://eprints.soton.ac.uk/id/eprint/452566
ISSN: 0306-5251
PURE UUID: 4576ff0a-4dcc-431a-98d7-efde1a7ae70b
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Date deposited: 11 Dec 2021 11:27
Last modified: 18 Mar 2024 05:11
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Author:
Lauren E Walker
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