Targeting cancer associated fibroblasts to enhance immunotherapy: emerging strategies and future perspectives
Targeting cancer associated fibroblasts to enhance immunotherapy: emerging strategies and future perspectives
Cancer associated fibroblasts are a prominent component of the tumour microenvironment in most solid cancers. This heterogeneous population of cells are known to play an important role in tumour progression and recent studies have demonstrated that CAFs may confer resistance to checkpoint immunotherapy, suggesting that targeting these cells could improve response rates. However, effective clinical strategies for CAF targeting have yet to be identified. In this editorial, we highlight current limitations in our understanding of CAF heterogeneity, and discuss the potential and possible approaches for CAF-directed therapy.
Cancer associated fibroblasts, Immunotherapy, Tumour microenvironment
1427-1433
Hanley, Christopher J.
7e2d840d-e724-4389-a362-83741ccdf241
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
6 July 2021
Hanley, Christopher J.
7e2d840d-e724-4389-a362-83741ccdf241
Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Hanley, Christopher J. and Thomas, Gareth J.
(2021)
Targeting cancer associated fibroblasts to enhance immunotherapy: emerging strategies and future perspectives.
Oncotarget, 12 (14), .
(doi:10.18632/oncotarget.27936).
Abstract
Cancer associated fibroblasts are a prominent component of the tumour microenvironment in most solid cancers. This heterogeneous population of cells are known to play an important role in tumour progression and recent studies have demonstrated that CAFs may confer resistance to checkpoint immunotherapy, suggesting that targeting these cells could improve response rates. However, effective clinical strategies for CAF targeting have yet to be identified. In this editorial, we highlight current limitations in our understanding of CAF heterogeneity, and discuss the potential and possible approaches for CAF-directed therapy.
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Published date: 6 July 2021
Additional Information:
Copyright: © 2021 Hanley and Thomas.
Keywords:
Cancer associated fibroblasts, Immunotherapy, Tumour microenvironment
Identifiers
Local EPrints ID: 452846
URI: http://eprints.soton.ac.uk/id/eprint/452846
ISSN: 1949-2553
PURE UUID: 71c17804-fa7f-42fe-b248-d43bcdc936ce
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Date deposited: 21 Dec 2021 17:55
Last modified: 17 Mar 2024 03:37
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