Metabolic messengers: tumour necrosis factor
Metabolic messengers: tumour necrosis factor
Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also the first ‘adipokine’ described to be produced from adipose tissue, regulated in obesity and proposed to contribute to obesity-associated metabolic disease. In this review, we provide an overview of TNF in the context of metabolic inflammation or metaflammation, its discovery as a metabolic messenger, its sites and mechanisms of action and some critical considerations for future research. Although we focus on TNF and the studies that elucidated its immunometabolic actions, we highlight a conceptual framework, generated by these studies, that is equally applicable to the complex network of pro-inflammatory signals, their biological activity, and their integration with metabolic regulation, and to the field of immunometabolism more broadly.
1302-1312
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Hotamisligil, Gökhan S.
59ea0e53-a259-4224-9d24-d503c4a29d15
14 October 2021
Sethi, Jaswinder K.
923f1a81-91e4-46cd-8853-bb4a979f5a85
Hotamisligil, Gökhan S.
59ea0e53-a259-4224-9d24-d503c4a29d15
Sethi, Jaswinder K. and Hotamisligil, Gökhan S.
(2021)
Metabolic messengers: tumour necrosis factor.
Nature Metabolism, 3 (10), .
(doi:10.1038/s42255-021-00470-z).
Abstract
Tumour necrosis factor (TNF) is a classical, pleiotropic pro-inflammatory cytokine. It is also the first ‘adipokine’ described to be produced from adipose tissue, regulated in obesity and proposed to contribute to obesity-associated metabolic disease. In this review, we provide an overview of TNF in the context of metabolic inflammation or metaflammation, its discovery as a metabolic messenger, its sites and mechanisms of action and some critical considerations for future research. Although we focus on TNF and the studies that elucidated its immunometabolic actions, we highlight a conceptual framework, generated by these studies, that is equally applicable to the complex network of pro-inflammatory signals, their biological activity, and their integration with metabolic regulation, and to the field of immunometabolism more broadly.
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Accepted/In Press date: 31 August 2021
e-pub ahead of print date: 14 October 2021
Published date: 14 October 2021
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Local EPrints ID: 452881
URI: http://eprints.soton.ac.uk/id/eprint/452881
ISSN: 2522-5812
PURE UUID: 4d9f50aa-6f0a-4ac4-945d-23403bc2d67b
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Date deposited: 06 Jan 2022 17:39
Last modified: 17 Mar 2024 03:47
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Author:
Gökhan S. Hotamisligil
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