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Management of anaphylaxis due to COVID-19 vaccines in the elderly

Management of anaphylaxis due to COVID-19 vaccines in the elderly
Management of anaphylaxis due to COVID-19 vaccines in the elderly

Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.

COVID-19 vaccines, adrenaline, anaphylaxis, older (adults/people)
0105-4538
2952-2964
Bousquet, Jean
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Agache, Ioana
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Blain, Hubert
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Jutel, Marek
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Worm, Margitta
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Canonica, G Walter
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Casale, Thomas
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Christoff, George
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El-Gamal, Yehia
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Ebisawa, Motohiro
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Eberlein, Bernadette
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Farrell, John
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Fernandez-Rivas, Montserrat
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Gao, Yadong
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Gavazzi, Gaëtan
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Gawlik, Radoslaw
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Gelincik, Asli
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Gemicioğlu, Bilun
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Bousquet, Jean
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Agache, Ioana
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Blain, Hubert
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Jutel, Marek
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Ventura, Maria Teresa
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Worm, Margitta
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Del Giacco, Stefano
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Benetos, Athanasios
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Bilo, Beatrice Maria
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Czarlewski, Wienczyslawa
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Al-Ahmad, Mona
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Angier, Elizabeth
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Annesi-Maesano, Isabella
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Bachert, Claus
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Barbaud, Annick
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Bedbrook, Anna
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Bennoor, Kazi S
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Bindslev-Jensen, Carsten
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Bonini, Sergio
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Brockow, Knut
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Brussino, Luisa
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Camargos, Paulo
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Canonica, G Walter
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Cardona, Victoria
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Carreiro-Martins, Pedro
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Carriazo, Ana
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Casale, Thomas
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Caubet, Jean-Christoph
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Cecchi, Lorenzo
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Cherubini, Antonio
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Christoff, George
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Chu, Derek K
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Cruz, Alvaro A
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Dokic, Dejan
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El-Gamal, Yehia
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Ebisawa, Motohiro
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Eberlein, Bernadette
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Farrell, John
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Fernandez-Rivas, Montserrat
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Fokkens, Wytske J
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Fonseca, Joao A
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Gao, Yadong
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Gavazzi, Gaëtan
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Gawlik, Radoslaw
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Gelincik, Asli
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Gemicioğlu, Bilun
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Bousquet, Jean, Agache, Ioana, Blain, Hubert, Jutel, Marek, Ventura, Maria Teresa, Worm, Margitta, Del Giacco, Stefano, Benetos, Athanasios, Bilo, Beatrice Maria, Czarlewski, Wienczyslawa, Abdul Latiff, Amir Hamzah, Al-Ahmad, Mona, Angier, Elizabeth, Annesi-Maesano, Isabella, Atanaskovic-Markovic, Marina, Bachert, Claus, Barbaud, Annick, Bedbrook, Anna, Bennoor, Kazi S, Berghea, Elena Camelia, Bindslev-Jensen, Carsten, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Brockow, Knut, Brussino, Luisa, Camargos, Paulo, Canonica, G Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Carriazo, Ana, Casale, Thomas, Caubet, Jean-Christoph, Cecchi, Lorenzo, Cherubini, Antonio, Christoff, George, Chu, Derek K, Cruz, Alvaro A, Dokic, Dejan, El-Gamal, Yehia, Ebisawa, Motohiro, Eberlein, Bernadette, Farrell, John, Fernandez-Rivas, Montserrat, Fokkens, Wytske J, Fonseca, Joao A, Gao, Yadong, Gavazzi, Gaëtan, Gawlik, Radoslaw, Gelincik, Asli and Gemicioğlu, Bilun (2021) Management of anaphylaxis due to COVID-19 vaccines in the elderly. Allergy, 76 (10), 2952-2964. (doi:10.1111/all.14838).

Record type: Article

Abstract

Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.

This record has no associated files available for download.

More information

Accepted/In Press date: 29 March 2021
e-pub ahead of print date: 2 April 2021
Published date: 30 September 2021
Keywords: COVID-19 vaccines, adrenaline, anaphylaxis, older (adults/people)

Identifiers

Local EPrints ID: 452920
URI: http://eprints.soton.ac.uk/id/eprint/452920
ISSN: 0105-4538
PURE UUID: 3030d538-7931-4cf8-8b22-88ca9c8353e9

Catalogue record

Date deposited: 06 Jan 2022 17:50
Last modified: 16 Mar 2024 15:15

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Contributors

Author: Jean Bousquet
Author: Ioana Agache
Author: Hubert Blain
Author: Marek Jutel
Author: Maria Teresa Ventura
Author: Margitta Worm
Author: Stefano Del Giacco
Author: Athanasios Benetos
Author: Beatrice Maria Bilo
Author: Wienczyslawa Czarlewski
Author: Amir Hamzah Abdul Latiff
Author: Mona Al-Ahmad
Author: Elizabeth Angier
Author: Isabella Annesi-Maesano
Author: Marina Atanaskovic-Markovic
Author: Claus Bachert
Author: Annick Barbaud
Author: Anna Bedbrook
Author: Kazi S Bennoor
Author: Elena Camelia Berghea
Author: Carsten Bindslev-Jensen
Author: Sergio Bonini
Author: Sinthia Bosnic-Anticevich
Author: Knut Brockow
Author: Luisa Brussino
Author: Paulo Camargos
Author: G Walter Canonica
Author: Victoria Cardona
Author: Pedro Carreiro-Martins
Author: Ana Carriazo
Author: Thomas Casale
Author: Jean-Christoph Caubet
Author: Lorenzo Cecchi
Author: Antonio Cherubini
Author: George Christoff
Author: Derek K Chu
Author: Alvaro A Cruz
Author: Dejan Dokic
Author: Yehia El-Gamal
Author: Motohiro Ebisawa
Author: Bernadette Eberlein
Author: John Farrell
Author: Montserrat Fernandez-Rivas
Author: Wytske J Fokkens
Author: Joao A Fonseca
Author: Yadong Gao
Author: Gaëtan Gavazzi
Author: Radoslaw Gawlik
Author: Asli Gelincik
Author: Bilun Gemicioğlu

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