The potential utility of liposomes for Neisseria vaccines
The potential utility of liposomes for Neisseria vaccines
INTRODUCTION: Species of the genus Neisseria are important global pathogens. Neisseria gonorrhoeae (gonococcus) causes the sexually transmitted disease gonorrhea and Neisseria meningitidis (meningococcus) causes meningitis and sepsis. Liposomes are self-assembled spheres of phospholipid bilayers enclosing a central aqueous space, and they have attracted much interest and use as a delivery vehicle for Neisseria vaccine antigens.
AREAS COVERED: A brief background on Neisseria infections and the success of licensed meningococcal vaccines are provided. The absence of a gonococcal vaccine is highlighted. The use of liposomes for delivering Neisseria antigens and adjuvants, for the purposes of generating specific immune responses, is reviewed. The use of other lipid-based systems for antigen and adjuvant delivery is examined briefly.
EXPERT OPINION: With renewed interest in developing a gonococcal vaccine, liposomes remain an attractive option for delivering antigens. The discipline of nanotechnology provides additional nanoparticle-based options for gonococcal vaccine development. Future work would be needed to tailor the composition of liposomes and other nanoparticles to the specific vaccine antigen(s), in order to generate optimal anti-gonococcal immune responses. The potential use of liposomes and other nanoparticles to deliver anti-gonococcal compounds to treat infections also should be explored further.
Antigen/adjuvant delivery, Neisseria gonorrhoeae, Neisseria meningitidis, antimicrobials, liposomes, nanoparticles, outer membrane, recombinant proteins, vaccine
1235-1256
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Humbert, Maria Victoria
82134d25-24b8-4fdd-bd1c-461683b5322e
Heckels, John E
fcfcfafe-5ca8-4728-9c5e-cb67f9af7e31
3 October 2021
Christodoulides, Myron
eba99148-620c-452a-a334-c1a52ba94078
Humbert, Maria Victoria
82134d25-24b8-4fdd-bd1c-461683b5322e
Heckels, John E
fcfcfafe-5ca8-4728-9c5e-cb67f9af7e31
Christodoulides, Myron, Humbert, Maria Victoria and Heckels, John E
(2021)
The potential utility of liposomes for Neisseria vaccines.
Expert Review of Vaccines, 20 (10), .
(doi:10.1080/14760584.2021.1981865).
Abstract
INTRODUCTION: Species of the genus Neisseria are important global pathogens. Neisseria gonorrhoeae (gonococcus) causes the sexually transmitted disease gonorrhea and Neisseria meningitidis (meningococcus) causes meningitis and sepsis. Liposomes are self-assembled spheres of phospholipid bilayers enclosing a central aqueous space, and they have attracted much interest and use as a delivery vehicle for Neisseria vaccine antigens.
AREAS COVERED: A brief background on Neisseria infections and the success of licensed meningococcal vaccines are provided. The absence of a gonococcal vaccine is highlighted. The use of liposomes for delivering Neisseria antigens and adjuvants, for the purposes of generating specific immune responses, is reviewed. The use of other lipid-based systems for antigen and adjuvant delivery is examined briefly.
EXPERT OPINION: With renewed interest in developing a gonococcal vaccine, liposomes remain an attractive option for delivering antigens. The discipline of nanotechnology provides additional nanoparticle-based options for gonococcal vaccine development. Future work would be needed to tailor the composition of liposomes and other nanoparticles to the specific vaccine antigen(s), in order to generate optimal anti-gonococcal immune responses. The potential use of liposomes and other nanoparticles to deliver anti-gonococcal compounds to treat infections also should be explored further.
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Published date: 3 October 2021
Additional Information:
Funding Information:
M Christodoulides and JE Heckels have previously received funding from GlaxoSmithKline (GSK) for research into Neisseria vaccines and received royalties for a licensed patent. M Christodoulides has received funding from GSK to support a PhD studentship for N. gonorrhoeae pathogenesis and vaccine studies.
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
Keywords:
Antigen/adjuvant delivery, Neisseria gonorrhoeae, Neisseria meningitidis, antimicrobials, liposomes, nanoparticles, outer membrane, recombinant proteins, vaccine
Identifiers
Local EPrints ID: 452964
URI: http://eprints.soton.ac.uk/id/eprint/452964
ISSN: 1476-0584
PURE UUID: a9ac4c08-4ad2-44bb-bbd4-90c4968dc606
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Date deposited: 07 Jan 2022 11:48
Last modified: 17 Mar 2024 03:35
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Author:
Maria Victoria Humbert
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