Influence of the human gut microbiome on the metabolic phenotype
Influence of the human gut microbiome on the metabolic phenotype
The gastrointestinal tract supports a vast community of microbes (bacteria, archea, lower eukaryotes, viruses), collectively termed the gut microbiota. Genetic diversity within this microbial ecosystem is some 50-100 times greater than that of the human host. The collective genes of these microbes encode extensive biotransformation capabilities that extend the functional capacity of the host. As such, gut microbes play a significant role in the metabolism of many endogenous, xenobiotic, and dietary molecules and are considered a major component of mammalian biocomplexity. The gut microbiota is highly host specific and shaped by a myriad of intrinsic and extrinsic host factors. Such variation in the compositional structure of the microbiota and its resultant functional variation can influence the metabolic phenotype of the host. This chapter will introduce the key metabolic reactions performed by the gut microbiota and their implications for the host.
Bile acids, Fermentation, Gastrointestinal tract, Methylamines, Microbiomics, Microbiota, Phytochemicals, Proteins, Short-chain fatty acids
535-560
Hoyles, Lesley
b066cc19-0372-48ca-a8a4-213c0b66cc74
Swann, Jonathan
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
2019
Hoyles, Lesley
b066cc19-0372-48ca-a8a4-213c0b66cc74
Swann, Jonathan
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Hoyles, Lesley and Swann, Jonathan
(2019)
Influence of the human gut microbiome on the metabolic phenotype.
In,
Lindon, John C., Nicholson, Jeremey K. and Holmes, Elaine
(eds.)
The Handbook of Metabolic Phenotyping.
Elsevier, .
(doi:10.1016/B978-0-12-812293-8.00018-9).
Record type:
Book Section
Abstract
The gastrointestinal tract supports a vast community of microbes (bacteria, archea, lower eukaryotes, viruses), collectively termed the gut microbiota. Genetic diversity within this microbial ecosystem is some 50-100 times greater than that of the human host. The collective genes of these microbes encode extensive biotransformation capabilities that extend the functional capacity of the host. As such, gut microbes play a significant role in the metabolism of many endogenous, xenobiotic, and dietary molecules and are considered a major component of mammalian biocomplexity. The gut microbiota is highly host specific and shaped by a myriad of intrinsic and extrinsic host factors. Such variation in the compositional structure of the microbiota and its resultant functional variation can influence the metabolic phenotype of the host. This chapter will introduce the key metabolic reactions performed by the gut microbiota and their implications for the host.
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e-pub ahead of print date: 12 October 2018
Published date: 2019
Additional Information:
Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.
Keywords:
Bile acids, Fermentation, Gastrointestinal tract, Methylamines, Microbiomics, Microbiota, Phytochemicals, Proteins, Short-chain fatty acids
Identifiers
Local EPrints ID: 453088
URI: http://eprints.soton.ac.uk/id/eprint/453088
PURE UUID: da882cca-6c0b-4dbb-85c3-ac2744fa73a9
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Date deposited: 07 Jan 2022 18:07
Last modified: 06 Jun 2024 02:08
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Contributors
Author:
Lesley Hoyles
Editor:
John C. Lindon
Editor:
Jeremey K. Nicholson
Editor:
Elaine Holmes
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